Protein Information

General Information
MoonProt ID401
First appeared in release3.0
Name(s)2-cys peroxiredoxin, Prx, Prx1, gene: Smp_059480
UniProt ID
GO termsGO:0055114 oxidation-reduction process GO:0016209 antioxidant activity GO:0016491 oxidoreductase activity GO:0051920 peroxiredoxin activity GO:0055114 oxidation-reduction process GO:0004601 peroxidase activity GO:0016491 oxidoreductase activity GO:0051920 peroxiredoxin activity GO:0051920 peroxiredoxin activity GO:0098869 cellular oxidant detoxification GO:0098869 cellular oxidant detoxification GO:0098869 cellular oxidant detoxification GO:0098869 cellular oxidant detoxification GO:0098869 cellular oxidant detoxification
Organisms for which functions have been demonstratedhuman parasite Schistosoma mansoni(Blood fluke)
Sequence length185 amino acids
FASTA sequence>tr|G4VKD9|G4VKD9_SCHMA Peroxiredoxin, Prx1 OS=Schistosoma mansoni OX=6183 GN=Smp_059480 PE=4 SV=1 MVLLPNRPAPEFKGQAVINGEFKEICLKDYRGKYVVLFFYPSDFTFVCPTEIIAFSDQVEEFNSRNCQVIACSTDSQYSHLAWDNLDRKSGGLGHMKIPLLADRKQEISKAYGVFDEEDGNAFRGLFIIDPNGILRQITINDKPVGRSVDETLRLLDAFQFVEKHGEVCPVNWKRGQHGIKVNQK
Structure Information
PDB IDNA
Quaternary structureDecameric ring assembly for SmPrxI-LMW and a double decamer for SmPrxl-HMWr
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder RegionsNA
Connections to Disease
OMIM ID
Function 1
Function descriptionperoxidase (Sm-Prxl-LMW), thioredoxin-dependent peroxidase in the absence of oxidative stress, uses redox-active cysteine to reduce H2O2
References for function22405002
E.C. number1.11.1.15
Location of functional site(s)Cysteine sulfenic acid (-SOH) intermediate; active sites are in the fully folded (FF) conformation in the first turn of the alpha 2 helix and beta 3 - alpha 2 loop
Cellular location of functionmitochondria
CommentsLMW decamer
Function 2
Function descriptionchaperone, ATP-independent holdases at high hydrogen peroxide concentrations, prevent protein aggregation by quarantining client proteins
References for function22405002
E.C. numberNA
Location of functional site(s)NA
Cellular location of functionCytoplasm
Commentshas a weak presence at pH 4.2 under reducing conditions, active when overoxidized SmPrxI-SO2H/SO3H is at pH 7, HMW 20-mer formed by two stacked decamers