| General Information |
| MoonProt ID | 4016 |
| First appeared in release | 4.0 |
| Name(s) | Chloride intracellular channel protein 1 |
| UniProt ID | O00299 |
| GO terms | "GO:0006821 chloride transport; GO:0045669 positive regulation of osteoblast differentiation; GO:0051881 regulation of mitochondrial membrane potential; GO:0005254 chloride channel activity; GO:0005515 protein binding; GO:0016491 oxidoreductase activity; GO:0045174 glutathione dehydrogenase (ascorbate) activity; GO:0045296 cadherin binding; GO:0006811 monoatomic ion transport; GO:0006821 chloride transport; GO:0007165 signal transduction; GO:0034220 monoatomic ion transmembrane transport; GO:0070527 platelet aggregation; GO:0098869 cellular oxidant detoxification; GO:1902476 chloride transmembrane transport; GO:0005737 cytoplasm; GO:0016020 membrane; GO:0005615 extracellular space; GO:0005634 nucleus; GO:0005635 nuclear envelope; GO:0005783 endoplasmic reticulum; GO:0005886 plasma membrane; GO:0005903 brush border; GO:0031982 vesicle; GO:0048471 perinuclear region of cytoplasm; GO:0070062 extracellular exosome; GO:0072562 blood microparticle; GO:0034702 monoatomic ion channel complex; GO:0034707 chloride channel complex; " |
| Organisms for which functions have been demonstrated | Homo sapiens (Human) |
| Sequence length | 241.0 |
| FASTA sequence | ">sp|O00299|CLIC1_HUMAN Chloride intracellular channel protein 1 OS=Homo sapiens OX=9606 GN=CLIC1 PE=1 SV=4
MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCP
GGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKN
SNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNL
LPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKAL
K" |
| Structure Information |
| PDB ID | 1K0M, 1K0N, 1K0O, 1RK4, 3O3T, 3P8W, 3P90, 3QR6, 3SWL, 3TGZ, 3UVH, 4IQA, 4JZQ, 4K0G, 4K0N, 7F8R, 7FBQ |
| Quaternary structure | NA |
| SCOP | "80253651K0M A:92-240
80253681K0M A:6-91
80377441K0M A:92-240
80377471K0M A:6-91" |
| CATH | "80253651K0M A:92-240
80253681K0M A:6-91
80377441K0M A:92-240
80377471K0M A:6-91" |
| TM Helix Prediction | NA |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | ion channel |
| References for function | Alghalayini A, Hossain KR, Moghaddasi S, Turkewitz DR, D'Amario C, Wallach M, Valenzuela SM. In Vitro Enzymatic Studies Reveal pH and Temperature Sensitive Properties of the CLIC Proteins. Biomolecules. 2023 Sep 15;13(9):1394. doi: 10.3390/biom13091394. PMID: 37759794; PMCID: PMC10526857. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | membrane |
| Comments | |
| Function 2 |
| Function description | enzyme, glutaredoxin-like oxidoreductase |
| References for function | Alghalayini A, Hossain KR, Moghaddasi S, Turkewitz DR, D'Amario C, Wallach M, Valenzuela SM. In Vitro Enzymatic Studies Reveal pH and Temperature Sensitive Properties of the CLIC Proteins. Biomolecules. 2023 Sep 15;13(9):1394. doi: 10.3390/biom13091394. PMID: 37759794; PMCID: PMC10526857. |
| E.C. number | EC:1.8.5.1 |
| Location of functional site(s) | |
| Cellular location of function | membrane |
| Comments | |