| General Information |
| MoonProt ID | 403 |
| First appeared in release | 3.0 |
| Name(s) | elongation factor 2, EF-2, gene: EFT2 |
| UniProt ID | Q5A0M4 |
| GO terms | GO:0003924 GTPase activity F
GO:0008144 drug binding F
GO:0035690 cellular response to drug
GO:0005886 plasma membrane
GO:0030445 yeast-form cell wall
GO:0003746 translation elongation factor activity
GO:0009986 cell surface
GO:0016020 membrane
GO:0008144 drug binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0006414 translational elongation
GO:0043022 ribosome binding
GO:1990904 ribonucleoprotein complex
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0006414 translational elongation
GO:0005525 GTP binding
GO:0003746 translation elongation factor activity
GO:0006412 translation
GO:0000166 nucleotide binding
GO:0005737 cytoplasm
|
| Organisms for which functions have been demonstrated | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| Sequence length | 842 amino acids |
| FASTA sequence | >sp|Q5A0M4|EF2_CANAL Elongation factor 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=EFT2 PE=1 SV=2
MVAFTIEQIRGLMDKVTNVRNMSVIAHVDHGKSTLSDSLVQKAGIISAAKAGDARFMDTRKDEQERGITIKSTAISLYASMTDEDVKDIKQKTDGNSFLVNLIDSPGHVDFSSEVTAALRVTDGALVVVDTVEGVCVQTETVLRQALGERIKPVVVINKVDRALLELQTTKEDLYQTFARTVESVNVIISTYCDPVLGDVQVYPQKGTVAFASGLHGWAFTVRQFANKYSKKFGVDKEKMMERLWGDSYFNPKTKKWTNKDKDADGKPLERAFNMFILDPIFRLFAAIMNFKKDEIPVLLEKLEIQLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAETLYEGPSDDPFCTAIRNCDPNADLMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYQVGKKEDLFLKSIQRTVLMMGRSVEQIDDCPAGNIIGLVGIDQFLLKSGTITTNEAAHNMKVMKFSVSPVVQVAVEVKNANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGELHLEICLQDLENDHAGVPLRISPPVVSYRETVEGESSMVALSKSPNKHNRIYVKAQPIDEEVSLDIENGVINPRDDFKARARILADKHGWDVVDARKIWCFGPDGNGPNLVVDQTKAVQYLNEIKDSVVAAFQWATKEGPIFGENCRSVRVNILDVTLHADAIHRGGGQIIPTMRRVTYASMLLAEPAIQEPVFLVEIQCPENAIGGIYSVLNKKRGQVISEEQRPGTPLFTVKAYLPVNESFGFTGELRQATGGQAFPQLIFDHWQVMSGDVTDENSKPGAIVKEKRVRAGLKPEVPEYTEYYDKL |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
moonID_403_uniID_Q5A0M4 is 842 residues long, with 10 residues (1.19%) predicted as disordered.The protein has 1 short (< 30 residues) disorder segment and 0 long (>= 30 residues) disorder segments.
Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 257 and 266 in the sequence. The segment is 10 residues long (1.19 % of the total sequence length). |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Elongation factor in protein synthesis |
| References for function | 26636139 |
| E.C. number | 3.30.230.10 |
| Location of functional site(s) | NA |
| Cellular location of function | intracellular, cell surface |
| Comments | NA |
| Function 2 |
| Function description | Interaction with contact system proteins HK, FXII, and PPK |
| References for function | 22074954 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | extracellular |
| Comments | NA |