| General Information |
| MoonProt ID | 4032 |
| First appeared in release | 4.0 |
| Name(s) | DNA repair nuclease/redox regulator APEX1 |
| UniProt ID | P27695 |
| GO terms | GO:0045454 cell redox homeostasis GO:0003677 DNA binding GO:0003677 DNA binding GO:0003684 damaged DNA binding GO:0003684 damaged DNA binding GO:0003684 damaged DNA binding GO:0003691 double-stranded telomeric DNA binding GO:0003713 transcription coactivator activity GO:0003713 transcription coactivator activity GO:0003714 transcription corepressor activity GO:0003723 RNA binding GO:0003723 RNA binding GO:0003824 catalytic activity GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0004518 nuclease activity GO:0004519 endonuclease activity GO:0004519 endonuclease activity GO:0004519 endonuclease activity GO:0004520 DNA endonuclease activity GO:0004520 DNA endonuclease activity GO:0004523 RNA-DNA hybrid ribonuclease activity GO:0004527 exonuclease activity GO:0004528 phosphodiesterase I activity GO:0004844 uracil DNA N-glycosylase activity GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0005515 protein binding GO:0008081 phosphoric diester hydrolase activity GO:0008081 phosphoric diester hydrolase activity GO:0008081 phosphoric diester hydrolase activity GO:0008296 3'-5'-DNA exonuclease activity GO:0008309 double-stranded DNA exodeoxyribonuclease activity GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity GO:0008408 3'-5' exonuclease activity GO:0008408 3'-5' exonuclease activity GO:0016491 oxidoreductase activity GO:0016491 oxidoreductase activity GO:0016787 hydrolase activity GO:0031490 chromatin DNA binding GO:0033892 deoxyribonuclease (pyrimidine dimer) activity GO:0033892 deoxyribonuclease (pyrimidine dimer) activity GO:0046872 metal ion binding GO:0046872 metal ion binding GO:0052720 class II DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0052720 class II DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0052720 class II DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0052720 class II DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0090580 phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands GO:0140431 DNA-(abasic site) binding GO:0000723 telomere maintenance GO:0006281 DNA repair GO:0006281 DNA repair GO:0006281 DNA repair GO:0006284 base-excision repair GO:0006284 base-excision repair GO:0006287 base-excision repair, gap-filling GO:0006308 DNA catabolic process GO:0006310 DNA recombination GO:0006974 DNA damage response GO:0042981 regulation of apoptotic process GO:0043488 regulation of mRNA stability GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation GO:0045892 negative regulation of DNA-templated transcription GO:0045944 positive regulation of transcription by RNA polymerase II GO:0097698 telomere maintenance via base-excision repair GO:0005634 nucleus GO:0000781 chromosome, telomeric region GO:0005634 nucleus GO:0005634 nucleus GO:0005634 nucleus GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005654 nucleoplasm GO:0005730 nucleolus GO:0005730 nucleolus GO:0005730 nucleolus GO:0005737 cytoplasm GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005739 mitochondrion GO:0005739 mitochondrion GO:0005783 endoplasmic reticulum GO:0005783 endoplasmic reticulum GO:0005813 centrosome GO:0005840 ribosome GO:0016607 nuclear speck GO:0016607 nuclear speck GO:0048471 perinuclear region of cytoplasm GO:0005634 nucleus |
| Organisms for which functions have been demonstrated | Homo sapiens |
| Sequence length | 318.0 |
| FASTA sequence | ">sp|P27695|APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 OS=Homo sapiens OX=9606 GN=APEX1 PE=1 SV=2
MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA
TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS
APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV
RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF
GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI
RSKALGSDHCPITLYLAL" |
| Structure Information |
| PDB ID | "1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U 4IEM 4LND 4QH9 4QHD 4QHE 5CFG 5DFF 5DFH 5DFI 5DFJ 5DG0 5WN0 5WN1 5WN2 5WN3 5WN4 5WN5 6BOQ 6BOR 6BOS 6BOT 6BOU 6BOV 6BOW 6MK3 6MKK 6MKM 6MKO 6P93 6P94 6W0Q 6W2P 6W3L 6W3N 6W3Q 6W3U 6W43 6W4I 6W4T 7LPG 7LPH 7LPI 7LPJ 7MCR 7MEV 7SUV 7SVB 7TC2 7TC2 7TR7 7U50 9DP1 9DP2 9DP3 9DP4" |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, apurinic/apyrimidinic (AP) endonuclease enzyme involved in DNA repair. |
| References for function | _ |
| E.C. number | 3.1.11.2 |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |
| Function 2 |
| Function description | redox factor, redox reactions to activate several transcription factors |
| References for function | Xanthoudakis S, Miao G, Wang F, Pan YC, Curran T. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J. 1992 Sep;11(9):3323-35. doi: 10.1002/j.1460-2075.1992.tb05411.x. PMID: 1380454; PMCID: PMC556867. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |