| General Information |
| MoonProt ID | 4035 |
| First appeared in release | 4.0 |
| Name(s) | glucotransferase OpgH |
| UniProt ID | P62517 |
| GO terms | GO:0008361 regulation of cell size , GO:1900727 osmoregulated periplasmic glucan biosynthetic process , GO:1900727 osmoregulated periplasmic glucan biosynthetic process , GO:0005515 protein binding , GO:0016740 transferase activity , GO:0016757 glycosyltransferase activity , GO:0016758 hexosyltransferase activity , GO:0016758 hexosyltransferase activity , GO:0009250 glucan biosynthetic process , GO:0030244 cellulose biosynthetic process , GO:1900727 osmoregulated periplasmic glucan biosynthetic process , GO:0005886 plasma membrane , GO:0005886 plasma membrane , GO:0016020 membrane |
| Organisms for which functions have been demonstrated | Escherichia coli (strain K12) |
| Sequence length | 847.0 |
| FASTA sequence | ">sp|P62517|OPGH_ECOLI Glucans biosynthesis glucosyltransferase H OS=Escherichia coli (strain K12) OX=83333 GN=mdoH PE=1 SV=1
MNKTTEYIDAMPIAASEKAALPKTDIRAVHQALDAEHRTWAREDDSPQGSVKARLEQAWP
DSLADGQLIKDDEGRDQLKAMPEAKRSSMFPDPWRTNPVGRFWDRLRGRDVTPRYLARLT
KEEQESEQKWRTVGTIRRYILLILTLAQTVVATWYMKTILPYQGWALINPMDMVGQDLWV
SFMQLLPYMLQTGILILFAVLFCWVSAGFWTALMGFLQLLIGRDKYSISASTVGDEPLNP
EHRTALIMPICNEDVNRVFAGLRATWESVKATGNAKHFDVYILSDSYNPDICVAEQKAWM
ELIAEVGGEGQIFYRRRRRRVKRKSGNIDDFCRRWGSQYSYMVVLDADSVMTGDCLCGLV
RLMEANPNAGIIQSSPKASGMDTLYARCQQFATRVYGPLFTAGLHFWQLGESHYWGHNAI
IRVKPFIEHCALAPLPGEGSFAGSILSHDFVEAALMRRAGWGVWIAYDLPGSYEELPPNL
LDELKRDRRWCHGNLMNFRLFLVKGMHPVHRAVFLTGVMSYLSAPLWFMFLALSTALQVV
HALTEPQYFLQPRQLFPVWPQWRPELAIALFASTMVLLFLPKLLSILLIWCKGTKEYGGF
WRVTLSLLLEVLFSVLLAPVRMLFHTVFVVSAFLGWEVVWNSPQRDDDSTSWGEAFKRHG
SQLLLGLVWAVGMAWLDLRFLFWLAPIVFSLILSPFVSVISSRATVGLRTKRWKLFLIPE
EYSPPQVLVDTDRFLEMNRQRSLDDGFMHAVFNPSFNALATAMATARHRASKVLEIARDR
HVEQALNETPEKLNRDRRLVLLSDPVTMARLHFRVWNSPERYSSWVSYYEGIKLNPLALR
KPDAASQ" |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, glucosyltransferase, |
| References for function | _ |
| E.C. number | 2.4.1.123 |
| Location of functional site(s) | |
| Cellular location of function | membrane |
| Comments | |
| Function 2 |
| Function description | bind FtsZ, inhibits FtsZ ring formation in cell division |
| References for function | Hill NS, Buske PJ, Shi Y, Levin PA. A moonlighting enzyme links Escherichia coli cell size with central metabolism. PLoS Genet. 2013;9(7):e1003663. doi: 10.1371/journal.pgen.1003663. Epub 2013 Jul 25. PMID: 23935518; PMCID: PMC3723540. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytokinetic ring (midcell) |
| Comments | |