General Information |
MoonProt ID | 404 |
First appeared in release | 3.0 |
Name(s) | 6-phosphogluconate dehydrogenase, decarboxylating; gene: GND1 |
UniProt ID | A0A1D8PFS4 |
GO terms | GO:0005777 peroxisome
GO:0005829 cytosol
GO:0062040 fungal biofilm matrix
GO:0050661 NADP binding
GO:0046177 D-gluconate catabolic process
GO:0009051 pentose-phosphate shunt, oxidative branch
GO:0005829 cytosol
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0006098 pentose-phosphate shunt
GO:0050661 NADP binding
GO:0055114 oxidation-reduction process
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0016491 oxidoreductase activity
GO:0006098 pentose-phosphate shunt
GO:0055114 oxidation-reduction process
GO:0016491 oxidoreductase activity
GO:0019521 D-gluconate metabolic process
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0006098 pentose-phosphate shunt |
Organisms for which functions have been demonstrated | Candida albicans (yeast, a fungi, can cause candiadiasis) |
Sequence length | 495 amino acids |
FASTA sequence | >tr|A0A1D8PFS4|A0A1D8PFS4_CANAL 6-phosphogluconate dehydrogenase, decarboxylating OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=GND1 PE=3 SV=1
MSSAPKGDIGLIGLAVMGQNLILNMADHGYTVVAYNRTTAKVDRFLENEAKGKSILGAHSIKELVDQLKRPRRIMLLVKAGAPVDEFINQLLPYLEEGDIIIDGGNSHFPDSNRRYEELAKKGILFVGSGVSGGEEGARTGPSLMPGGNEKAWPHIKDIFQDVAAKSDGEPCCDWVGDAGAGHYVKMVHNGIEYGDMQLICEAYDLMKRVGKFEDKEIGDVFATWNKGVLDSFLIEITRDILYYNDPTDGKPLVEKILDTAGQKGTGKWTAVNALDLGIPVTLIGEAVFSRCLSAMKAERVEASKALKGPQVTGESPITDKKQFIDDLEQALYASKIISYTQGFMLMNQAAKDYGWKLNNAGIALMWRGGCIIRSVFLAEITAAYRKKPDLENLLLYPFFNDAITKAQSGWRASVGKAIQYGIPTPAFSTALAFYDGLRSERLPANLLQAQRDYFGAHTFKVLPGQENELLKKDEWIHINWTGRGGDVSSTTYDA |
Structure Information |
PDB ID | NA |
Quaternary structure | homodimer |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
moonID_404_uniID_A0A1D8P is 495 residues long, with 18 residues (3.64%) predicted as disordered.The protein has 2 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments.
Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 1 and 5 in the sequence. The segment is 5 residues long (1.01 % of the total sequence length).
Segment 2 - Short (< 30 residues) disordered segment Segment is located between positions 483 and 495 in the sequence. The segment is 13 residues long (2.63 % of the total sequence length). |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH. |
References for function | 375989 |
E.C. number | 1.1.1.44 |
Location of functional site(s) | NA |
Cellular location of function | cytosol, extracellular region or secreted |
Comments | involved in pentose phosphate pathway |
Function 2 |
Function description | binding to plasma proteins, interacting with components of contact system |
References for function | 26636139; 22074954 |
E.C. number | NA |
Location of functional site(s) | NA |
Cellular location of function | extracellular |
Comments | NA |