| General Information |
| MoonProt ID | 4044 |
| First appeared in release | 4.0 |
| Name(s) | Glyceraldehyde-3-phosphate dehydrogenase 2 |
| UniProt ID | Q6FSM4 |
| GO terms | "GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0005576 extracellular region
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009986 cell surface
GO:0030312 external encapsulating structure
GO:0062040 fungal biofilm matrix" |
| Organisms for which functions have been demonstrated | Candida glabrata |
| Sequence length | 332 |
| FASTA sequence | ">sp|Q6FSM4|G3P2_CANGA Glyceraldehyde-3-phosphate dehydrogenase 2 OS=Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) OX=284593 GN=GPD2 PE=3 SV=1
MVRIAINGFGRIGRLVLRVALSRSNIEVVAVNDPFITTDYAAYMFKYDSTHGRYAGEVTHDDKHIIIDGKKIAVHQERDPANLPWGSENIDIAIDSTGVFKELDTAQKHIDAGAKKVVITAPSSTAPMFVVGVNEDKYTSDLKIVSNASCTTNCLAPLAKVIDEAFGIEEGLMTTVHSLTATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKVLPQLQGKLTGMAFRVPTVDVSVVDLTVKLQKETTYDEIKKVIKQASEGKLKGVLGYTEDAVVSSDFLGDSRSSIFDASAGIQLSPKFVKLVSWYDNEYGYSTRVVDLVEHVAKN" |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, glyceraldehyde 3-phosphate dehydrogenase, carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate |
| References for function | _ |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | Aids in binding of fungal cells to vitronectin and plasminogen (human host proteins) |
| References for function | Bednarek, A., Satala, D., Zawrotniak, M., Nobbs, A. H., Rapala-Kozik, M., & Kozik, A. (2024). Glyceraldehyde 3-phosphate dehydrogenase on the surface of Candida albicans and Nakaseomyces glabratus cells—A moonlighting protein that binds human vitronectin and plasminogen and can adsorb to pathogenic fungal cells via major adhesins Als3 and Epa6. International Journal of Molecular Sciences, 25(2), 1013. https://doi.org/10.3390/ijms25021013 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |