Protein Information

General Information
MoonProt ID406
First appeared in release3.0
Name(s)peroxisomal catalase, gene: CAT1
UniProt IDO13289
GO termsGO:0004096 catalase activity GO:0005515 protein binding GO:0009267 cellular response to starvation GO:0030447 filamentous growth GO:0020037 heme binding GO:0042744 hydrogen peroxide catabolic process GO:0004096 catalase activity GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005777 peroxisome GO:0042542 response to hydrogen peroxide GO:0020037 heme binding GO:0055114 oxidation-reduction process GO:0004096 catalase activity GO:0006979 response to oxidative stress GO:0046872 metal ion binding GO:0055114 oxidation-reduction process GO:0004601 peroxidase activity GO:0042744 hydrogen peroxide catabolic process GO:0005777 peroxisome GO:0016491 oxidoreductase activity GO:0004096 catalase activity GO:0005777 peroxisome GO:0098869 cellular oxidant detoxification GO:0009277 fungal-type cell wall GO:0051701 interaction with host GO:0005515 protein binding
Organisms for which functions have been demonstratedCandida albicans (yeast, a fungi, can cause candiadiasis)
Sequence length485 amino acids
FASTA sequence>sp|O13289|CATA_CANAL Peroxisomal catalase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=CAT1 PE=2 SV=5 MAPTFTNSNGQPIPEPFATQRVGQHGPLLLQDFNLIDSLAHFDRERIPERVVHAKGSGAYGVFEVTDDITDICAAKFLDTVGKKTRIFTRFSTVGGELGSADTARDPRGFATKFYTEEGNLDLVYNNTPVFFIRDPSKFPHFIHTQKRNPETHLKDANMFWDYLTSNEESIHQVMVLFSDRGTPASYREMNGYSGHTYKWSNKKGEWFYVQVHFISDQGIKTLTNEEAGALAGSNPDYAQEDLFKNIAAGNYPSWTAYIQTMTEAEAKEAEFSVFDLTKVWPHKKYPLRRFGKFTLNENPKNYFAEVEQAAFSPAHTVPYMEPSADPVLQSRLFSYADTHRHRLGTNYTQIPVNCPVTGAVFNPHMRDGAMTVNGNLGSHPNYLASDKPVEFKQFSLQEDQEVWNGAATPFHWKATPADFKQAQELWKVLKRYPNQQEHLAHNIAVHAAGADAAIQDRVFAYFGKVSQDLADAIKKEVLELSPRK
Structure Information
PDB IDNA
Quaternary structureHomotetramer
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder RegionsUse FASTA sequence on the MFDp2 webserver. moonID_406_uniID_O13289 is 485 residues long, with 32 residues (6.60%) predicted as disordered.The protein has 2 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments. Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 1 and 19 in the sequence. The segment is 19 residues long (3.92 % of the total sequence length). Segment 2 - Short (< 30 residues) disordered segment Segment is located between positions 385 and 397 in the sequence. The segment is 13 residues long (2.68 % of the total sequence length).
Connections to Disease
OMIM ID
Function 1
Function descriptioncatalase activity
References for functionPoltermann, S.; Kunert, A.; Von Der Heide, M.; Eck, R.; Hartmann, A.; Zipfel, P.F. Gpm1p is a factor H-, FHL-1-, and plasminogen-binding surface protein of Candida albicans. J. Biol. Chem. 2007, 282, 37537–37544.
E.C. number1.11.1.6
Location of functional site(s)NA
Cellular location of functioncytosol
CommentsNA
Function 2
Function descriptionHPG-binding
References for function17959597
E.C. numberNA
Location of functional site(s)NA
Cellular location of functionextracellular
CommentsNA