| General Information |
| MoonProt ID | 4062 |
| First appeared in release | 4.0 |
| Name(s) | Beta-enolase - ENO3 |
| UniProt ID | P13929 |
| GO terms | GO:0000287 magnesium ion binding, GO:0004634 phosphopyruvate hydratase activity, GO:0005515 protein binding, GO:0016829 lyase activity, GO:0046872 metal ion binding, GO:0006094 gluconeogenesis, GO:0006096 glycolytic process, GO:0061621 canonical glycolysis, GO:0005829 cytosol, GO:0005615 extracellular space, GO:0005737 cytoplasm, GO:0005886 plasma membrane, GO:0016020 membrane, GO:0070062 extracellular exosome, GO:0000015 phosphopyruvate hydratase complex |
| Organisms for which functions have been demonstrated | Homo sapiens |
| Sequence length | 434.0 |
| FASTA sequence | ">sp|P13929|ENOB_HUMAN Beta-enolase OS=Homo sapiens OX=9606 GN=ENO3 PE=1 SV=5
MAMQKIFAREILDSRGNPTVEVDLHTAKGRFRAAVPSGASTGIYEALELRDGDKGRYLGK
GVLKAVENINNTLGPALLQKKLSVVDQEKVDKFMIELDGTENKSKFGANAILGVSLAVCK
AGAAEKGVPLYRHIADLAGNPDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFKE
AMRIGAEVYHHLKGVIKAKYGKDATNVGDEGGFAPNILENNEALELLKTAIQAAGYPDKV
VIGMDVAASEFYRNGKYDLDFKSPDDPARHITGEKLGELYKSFIKNYPVVSIEDPFDQDD
WATWTSFLSGVNIQIVGDDLTVTNPKRIAQAVEKKACNCLLLKVNQIGSVTESIQACKLA
QSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEALGDK
AIFAGRKFRNPKAK" |
| Structure Information |
| PDB ID | 2XSX |
| Quaternary structure | NA |
| SCOP | |
| CATH | 2xsxA01, 2xsxA02, 2xsxB01, 2xsxB02 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, enolase, 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. Carbohydrate degradation, glycolysis |
| References for function | _ |
| E.C. number | EC:4.2.1.11 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | tRK1 import into mitochondria |
| References for function | Baleva, M., Gowher, A., Kamenski, P., Tarassov, I., Entelis, N., & Masquida, B. (2015). A Moonlighting Human Protein Is Involved in Mitochondrial Import of tRNA. International journal of molecular sciences, 16(5), 9354–9367. https://doi.org/10.3390/ijms16059354 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytosol to mitochondria |
| Comments | |