| General Information |
| MoonProt ID | 4067 |
| First appeared in release | 4.0 |
| Name(s) | Mannose-6-phosphate isomerase 1 |
| UniProt ID | Q9M884 |
| GO terms | "GO:0009793 embryo development ending in seed dormancy
GO:0004476 mannose-6-phosphate isomerase activity
GO:0004476 mannose-6-phosphate isomerase activity
GO:0004476 mannose-6-phosphate isomerase activity
GO:0008270 zinc ion binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding
GO:0005975 carbohydrate metabolic process
GO:0009298 GDP-mannose biosynthetic process
GO:0009298 GDP-mannose biosynthetic process
GO:0009416 response to light stimulus
GO:0009416 response to light stimulus
GO:0010043 response to zinc ion
GO:0010043 response to zinc ion
GO:0032025 response to cobalt ion
GO:0033591 response to L-ascorbic acid
GO:0033591 response to L-ascorbic acid
GO:0046686 response to cadmium ion
GO:0046686 response to cadmium ion
GO:0005829 cytosol" |
| Organisms for which functions have been demonstrated | "
Arabidopsis thaliana (Mouse-ear cress)" |
| Sequence length | 432.0 |
| FASTA sequence | ">sp|Q9M884|MPI1_ARATH Mannose-6-phosphate isomerase 1 OS=Arabidopsis thaliana OX=3702 GN=PMI1 PE=1 SV=1
MEIATVVKANGGCEADRRRLRRLRCSVKDYDWGKIGSDSLVYRVYAANSDYEIDPTRPYA
ELWMGTHESGPSYLEDADGSNGVTLRSWITENPKSLGNRVLEKWGCDLPFLFKVLSVARP
LSIQAHPDKKLAKKMHKAHPNLYKDDNHKPEMALAYTQFEALCGFIPLQELKSVIRAIPE
IEELVGSEEANQVFCITEHDEEKVKSVVRTIFTLLMSADADTTKKIVSKLKRRLHMESQE
RQLTDKERLVLKLEKQYPNDIGVISAFFFNYVKLNPGEALYLGANEPHAYLFGECLEVMA
TSDNVVRAGLTSKPLDIQTLCSMLSYKLGYPEILKGTRIRPYITRYLPPFEEFEVDLCDL
PSGASTVFPSVPGPSLLLVLQGEGRMSTEASADGISMGDVLFVPADTEIHLRSSSDLKLY
RAGINSRFLFPL" |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, phosphomannose isomerase |
| References for function | _ |
| E.C. number | EC:5.3.1.8 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | regulator of KAT1 potassium channel |
| References for function | González-García A, Kanli M, Wisowski N, Montoliu-Silvestre E, Locascio A, Sifres A, Gómez M, Ramos J, Porcel R, Andrés-Colás N, Mulet JM, Yenush L. Maternal Embryo Effect Arrest 31 (MEE31) is a moonlighting protein involved in GDP-D-mannose biosynthesis and KAT1 potassium channel regulation. Plant Sci. 2024 Jan;338:111897. doi: 10.1016/j.plantsci.2023.111897. Epub 2023 Oct 17. PMID: 37852415. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasmic side of membrane |
| Comments | |