| General Information |
| MoonProt ID | 408 |
| First appeared in release | 3.0 |
| Name(s) | Aire, autoimmune regulator, APECED protein homolog, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog |
| UniProt ID | Q9Z0E3 |
| GO terms | GO:0004601 peroxidase activity
GO:0055114 oxidation-reduction process
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0005737 cytoplasm
GO:0019430 removal of superoxide radicals
GO:0008379 thioredoxin peroxidase activity
GO:0008430 selenium binding
GO:0048538 thymus development
|
| Organisms for which functions have been demonstrated | Mus musculus (Mouse, mammal) |
| Sequence length | 552 amino acids |
| FASTA sequence | >sp|Q9Z0E3|AIRE_MOUSE Autoimmune regulator OS=Mus musculus OX=10090 GN=Aire PE=1 SV=1
MAGGDGMLRRLLRLHRTEIAVAIDSAFPLLHALADHDVVPEDKFQETLRLKEKEGCPQAFHALLSWLLTRDSGAILDFWRILFKDYNLERYSRLHSILDGFPKDVDLNQSRKGRKPLAGPKAAVLPPRPPTKRKALEEPRATPPATLASKSVSSPGSHLKTKPPKKPDGNLESQHLPLGNGIQTMAASVQRAVTVASGDVPGTRGAVEGILIQQVFESGRSKKCIQVGGEFYTPNKFEDPSGNLKNKARSGSSLKPVVRAKGAQVTIPGRDEQKVGQQCGVPPLPSLPSEPQVNQKNEDECAVCHDGGELICCDGCPRAFHLACLSPPLQEIPSGLWRCSCCLQGRVQQNLSQPEVSRPPELPAETPILVGLRSASEKTRGPSRELKASSDAAVTYVNLLAPHPAAPLLEPSALCPLLSAGNEGRPGPAPSARCSVCGDGTEVLRCAHCAAAFHWRCHFPTAAARPGTNLRCKSCSADSTPTPGTPGEAVPTSGPRPAPGLAKVGDDSASHDPVLHRDDLESLLNEHSFDGILQWAIQSMSRPLAETPPFSS |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | Predicted disorder at N terminus (aa 1-4), middle region (aa 108-181, 239-291, 354-386, 482-516), and C terminus (aa 544-552) |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Autoimmune regulator; Transcription factor that regulates the expression of many tissue restricted antigens (TRA) |
| References for function | 19923453 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | nucleus |
| Comments | NA |
| Function 2 |
| Function description | Binds to several spindle proteins including AURKB, CEP55, CNTROB, HAUS5, HAUS8, CLASP1, and CLASP2 |
| References for function | 28742026 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | Spindle, central spindle |
| Comments | Aire loss results in abnormal spindle poles and centrosome amplification |