| General Information |
| MoonProt ID | 4085 |
| First appeared in release | 4.0 |
| Name(s) | BRASSINOSTEROID INSENSITIVE 1 |
| UniProt ID | O22476 |
| GO terms | "GO:0009414 response to water deprivation
GO:0009416 response to light stimulus
GO:0009729 detection of brassinosteroid stimulus
GO:0009742 brassinosteroid mediated signaling pathway
GO:0009742 brassinosteroid mediated signaling pathway
GO:0009911 positive regulation of flower development
GO:0010224 response to UV-B
GO:0010268 brassinosteroid homeostasis
GO:0010584 pollen exine formation
GO:0048366 leaf development
GO:0048657 anther wall tapetum cell differentiation
GO:0000149 SNARE binding
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005496 steroid binding
GO:0005496 steroid binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008289 lipid binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0042802 identical protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0106310 protein serine kinase activity
GO:0001578 microtubule bundle formation
GO:0009416 response to light stimulus
GO:0009647 skotomorphogenesis
GO:0009729 detection of brassinosteroid stimulus
GO:0009742 brassinosteroid mediated signaling pathway
GO:0009755 hormone-mediated signaling pathway
GO:0009791 post-embryonic development
GO:0090351 seedling development
GO:0005886 plasma membrane
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005886 plasma membrane
GO:0005886 plasma membrane
GO:0005886 plasma membrane
GO:0005886 plasma membrane
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0032991 protein-containing complex" |
| Organisms for which functions have been demonstrated | Arabidopsis thaliana (Mouse-ear cress) |
| Sequence length | 1196.0 |
| FASTA sequence | ">sp|O22476|BRI1_ARATH Protein BRASSINOSTEROID INSENSITIVE 1 OS=Arabidopsis thaliana OX=3702 GN=BRI1 PE=1 SV=1
MKTFSSFFLSVTTLFFFSFFSLSFQASPSQSLYREIHQLISFKDVLPDKNLLPDWSSNKN
PCTFDGVTCRDDKVTSIDLSSKPLNVGFSAVSSSLLSLTGLESLFLSNSHINGSVSGFKC
SASLTSLDLSRNSLSGPVTTLTSLGSCSGLKFLNVSSNTLDFPGKVSGGLKLNSLEVLDL
SANSISGANVVGWVLSDGCGELKHLAISGNKISGDVDVSRCVNLEFLDVSSNNFSTGIPF
LGDCSALQHLDISGNKLSGDFSRAISTCTELKLLNISSNQFVGPIPPLPLKSLQYLSLAE
NKFTGEIPDFLSGACDTLTGLDLSGNHFYGAVPPFFGSCSLLESLALSSNNFSGELPMDT
LLKMRGLKVLDLSFNEFSGELPESLTNLSASLLTLDLSSNNFSGPILPNLCQNPKNTLQE
LYLQNNGFTGKIPPTLSNCSELVSLHLSFNYLSGTIPSSLGSLSKLRDLKLWLNMLEGEI
PQELMYVKTLETLILDFNDLTGEIPSGLSNCTNLNWISLSNNRLTGEIPKWIGRLENLAI
LKLSNNSFSGNIPAELGDCRSLIWLDLNTNLFNGTIPAAMFKQSGKIAANFIAGKRYVYI
KNDGMKKECHGAGNLLEFQGIRSEQLNRLSTRNPCNITSRVYGGHTSPTFDNNGSMMFLD
MSYNMLSGYIPKEIGSMPYLFILNLGHNDISGSIPDEVGDLRGLNILDLSSNKLDGRIPQ
AMSALTMLTEIDLSNNNLSGPIPEMGQFETFPPAKFLNNPGLCGYPLPRCDPSNADGYAH
HQRSHGRRPASLAGSVAMGLLFSFVCIFGLILVGREMRKRRRKKEAELEMYAEGHGNSGD
RTANNTNWKLTGVKEALSINLAAFEKPLRKLTFADLLQATNGFHNDSLIGSGGFGDVYKA
ILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKVGDERLLVYEFMK
YGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDEN
LEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELL
TGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDD
RAWRRPTMVQVMAMFKEIQAGSGIDSQSTIRSIEDGGFSTIEMVDMSIKEVPEGKL" |
| Structure Information |
| PDB ID | "3RGX
3RGZ
3RIZ
3RJ0
4LSA
4LSX
4M7E
4OH4
4Q5J
5LPB
5LPV
5LPW
5LPY
5LPZ
6FIF" |
| Quaternary structure | monomer or dimer |
| SCOP | |
| CATH | 3.30.1490.310 |
| TM Helix Prediction | 2 |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, kinase |
| References for function | Wheeler JI, Wong A, Marondedze C, Groen AJ, Kwezi L, Freihat L, Vyas J, Raji MA, Irving HR, Gehring C. The brassinosteroid receptor BRI1 can generate cGMP enabling cGMP-dependent downstream signaling. Plant J. 2017 Aug;91(4):590-600. doi: 10.1111/tpj.13589. Epub 2017 Jun 12. PMID: 28482142. |
| E.C. number | EC:2.7.10.1 |
| Location of functional site(s) | |
| Cellular location of function | transmembrane protein, kinase domain in cytoplasm |
| Comments | |
| Function 2 |
| Function description | enzyme, guanydylate cyclase |
| References for function | Wheeler JI, Wong A, Marondedze C, Groen AJ, Kwezi L, Freihat L, Vyas J, Raji MA, Irving HR, Gehring C. The brassinosteroid receptor BRI1 can generate cGMP enabling cGMP-dependent downstream signaling. Plant J. 2017 Aug;91(4):590-600. doi: 10.1111/tpj.13589. Epub 2017 Jun 12. PMID: 28482142. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | transmembrane protein, GC domain in cytoplasm |
| Comments | |