| General Information |
| MoonProt ID | 409 |
| First appeared in release | 3.0 |
| Name(s) | Microtubule organization protein AKNA; AT-hook-containing transcription factor; gene: Akna |
| UniProt ID | Q80VW7 |
| GO terms | GO:0005813 centrosome
GO:0060234 neuroblast delamination
GO:0060232 delamination
GO:0021849 neuroblast division in subventricular zone
GO:0005814 centriole
GO:0005874 microtubule
GO:0001837 epithelial to mesenchymal transition
GO:0050727 regulation of inflammatory response
GO:0005515 protein binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001837 epithelial to mesenchymal transition
GO:0003677 DNA binding
GO:0005856 cytoskeleton
GO:0007399 nervous system development
GO:0005737 cytoplasm
GO:0005634 nucleus
GO:0005874 microtubule
GO:0043231 intracellular membrane-bounded organelle
GO:0005829 cytosol
GO:0005813 centrosome
GO:0005654 nucleoplasm GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0001650 fibrillar center
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0001650 fibrillar center
GO:0043231 intracellular membrane-bounded organelle
GO:0005829 cytosol
GO:0005813 centrosome
GO:0005654 nucleoplasm
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0005634 nucleus
GO:0005814 centriole |
| Organisms for which functions have been demonstrated | Mus musculus (Mouse, mammal) |
| Sequence length | 1,404 amino acids |
| FASTA sequence | >sp|Q80VW7|AKNA_MOUSE Microtubule organization protein AKNA OS=Mus musculus OX=10090 GN=Akna PE=1 SV=1
MASSGAKAQWVGPSLGQGPRRRRWAWAEEQDTDGRRDQGWGNSQSLPEAPSPELLEDFRRAQEHLPPLEWDPDMQDSEESSGEETEADDASSPEGSTVPLPWLSRSNQQLDMSEEELDEASGRPEVDLAGESCTELECEDQGDSSPPPPGQGPAKGWVTFIKQGSNYRPSEHLEAQPSVEHSRTKSWSSGTVSLRQPSDSLGSTWEGDTEVPQPSILPKALPQSPCHNFPHPGDRNGGDVAPATPTEFRDSLAAPAQNAECSAGTWGEETTSLPSSRPEDQTWKRTKTSPKPLPSRFTGSVSPLSTRLGAIKKVVPQHKQGATLAGHSSSQAPKYGRGRRLNYPLPDFSKVGPRVRFPKDENYRPPKSRGHNRQQGSTRPLIFKSPAEIVRDVLLSSGEASLAKESSLAHTITRVPQEFQTPEQATELVHQLQEDYHKLLTKYAEAENTIDQLRLGAKVHLYSDPPQPSQSFCSGSMPQG
SKVLSFSIPQPRVAEWWPDPAQDPQASEATGWPFPRTDLSPSSSPGVATPGRLPQSQGIATDQPSTGQTQALTSQASRLLAKVQSFEELVLAGHLPPQDQIKSLEQLRAAHMALEAEYLQACREELLDPQLDASQGSPRTLNLCRELEAEIYHLGQRLEELQDHMDQTQRETEPCRPDLQDSTPTMSFLPQSAHLSMPSGPVSLPDGQTYQEPATTTTTSPGSSCTLPINKKLSLSIKTEESPRGLPVPLRDRTLQVEQDFHGLLERYLSVKSLPEALRDEDEDDLEEEEEEQDHQGPLEVDSPATAPGKTEAVRVPPGERPTQAEESHRDATQEDEEQMGPMKSPDFRPSMARDTYTPVLDTAEVAQRGTKAMVSHQSSLTSLEESRPSELLPRKALLRAGGPHTEEPWMVSPETDSGFVGSETSIVSPFTQTPEHRLSHVSTSGPSAQHLTASVPGDRTSHPKARGLMVPRRATETGIPRSRTQQHFSSLSSPGRGAQSCHLEETSVAKIAVPRSEFKRQKQISKQLLPSGRTSPDSAPAPTAASTPHGSAESTANLLLNRTERDQAIKDLQAEVSRLRLQLEDSLHRPHPDGPACVASAFNHSTQTQEKLGSSPSWGPHYGSKSTERLSREPNGVEPAEPMGRRRARSSSVPRDVPRLYLSSESESPAPRLSSEKSRTFEEHPEAAQWGTRPQSSSKRRERVSFRGQYTGQEYHILSPKAILKDSGTPSCPHCHPIRTQDTGSAVSRDTTRGSSAADTLRCALCGEVKSSAEADGSSSGPSEKNTPKKPSTPILKRKNRQTGSPVRMAPGLWYLAAAPPAPAPPALAYISSAPIMPYLPPTVYYAAPAPTSAQTASPQPARGPRRTRHSVQLGLNDLEELQAALREAAQAAENVRSTTRQLSRSLSADLRHARSLRGSCLF |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | Predicted disorder at N terminus (aa 1-2), middle region (aa 75-146, 172-229), and C terminus (aa 277-282) |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | localizes to the distal part of the subdistal appendages of the mother centriole in interphase and dissociates from centrosomes during mitosis upon increased phosphorylation; re-associates with the centrosomes during late telophase/early G1 |
| References for function | 30787442 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | centrosome |
| Comments | NA |
| Function 2 |
| Function description | interacts with components of the gamma-tubulin ring complex (gamma-TuRC), and MT binding proteins such as EB1, P150-Glued (DCTN1), and dynein. |
| References for function | 30787442 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | centrosome |
| Comments | RNAi-mediated AKNA knockdown results in a significant reduction in centrosome-driven MT regrowthafter MT depolymerization with nocodazole |