| General Information |
| MoonProt ID | 4102 |
| First appeared in release | 4.0 |
| Name(s) | reptin, RuvB-2 |
| UniProt ID | Q9Y230 |
| GO terms | "GO:0010467 gene expression
GO:0090671 telomerase RNA localization to Cajal body
GO:0000166 nucleotide binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001094 TFIID-class transcription factor complex binding
GO:0003678 DNA helicase activity
GO:0003678 DNA helicase activity
GO:0003678 DNA helicase activity
GO:0003678 DNA helicase activity
GO:0003714 transcription corepressor activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008013 beta-catenin binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0016887 ATP hydrolysis activity
GO:0016887 ATP hydrolysis activity
GO:0016887 ATP hydrolysis activity
GO:0017025 TBP-class protein binding
GO:0017025 TBP-class protein binding
GO:0031490 chromatin DNA binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043531 ADP binding
GO:0051082 unfolded protein binding
GO:0051117 ATPase binding
GO:0140585 promoter-enhancer loop anchoring activity
GO:0000492 box C/D snoRNP assembly
GO:0000723 telomere maintenance
GO:0000723 telomere maintenance
GO:0006275 regulation of DNA replication
GO:0006275 regulation of DNA replication
GO:0006281 DNA repair
GO:0006281 DNA repair
GO:0006282 regulation of DNA repair
GO:0006282 regulation of DNA repair
GO:0006310 DNA recombination
GO:0006310 DNA recombination
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006338 chromatin remodeling
GO:0006338 chromatin remodeling
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006457 protein folding
GO:0006974 DNA damage response
GO:0033044 regulation of chromosome organization
GO:0033044 regulation of chromosome organization
GO:0034644 cellular response to UV
GO:0042981 regulation of apoptotic process
GO:0045739 positive regulation of DNA repair
GO:0045739 positive regulation of DNA repair
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045995 regulation of embryonic development
GO:0045995 regulation of embryonic development
GO:0050821 protein stabilization
GO:0050821 protein stabilization
GO:0050821 protein stabilization
GO:0051726 regulation of cell cycle
GO:0051726 regulation of cell cycle
GO:0060382 regulation of DNA strand elongation
GO:0060382 regulation of DNA strand elongation
GO:0071169 establishment of protein localization to chromatin
GO:0071392 cellular response to estradiol stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1904507 positive regulation of telomere maintenance in response to DNA damage
GO:1904507 positive regulation of telomere maintenance in response to DNA damage
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:2000779 regulation of double-strand break repair
GO:0000791 euchromatin
GO:0005634 nucleus
GO:0005634 nucleus
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005654 nucleoplasm
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0070062 extracellular exosome
GO:0120293 dynein axonemal particle
GO:0120293 dynein axonemal particle
GO:0000786 nucleosome
GO:0000786 nucleosome
GO:0000786 nucleosome
GO:0000812 Swr1 complex
GO:0000812 Swr1 complex
GO:0000812 Swr1 complex
GO:0031011 Ino80 complex
GO:0031011 Ino80 complex
GO:0031011 Ino80 complex
GO:0031011 Ino80 complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0071339 MLL1 complex
GO:0071339 MLL1 complex
GO:0097255 R2TP complex
GO:0097255 R2TP complex
GO:0097255 R2TP complex
GO:0097255 R2TP complex
GO:0101031 protein folding chaperone complex
GO:0101031 protein folding chaperone complex
GO:1990062 RPAP3/R2TP/prefoldin-like complex
GO:1990062 RPAP3/R2TP/prefoldin-like complex
GO:1990904 ribonucleoprotein complex" |
| Organisms for which functions have been demonstrated | Homo sapiens (Human) |
| Sequence length | 463.0 |
| FASTA sequence | ">sp|Q9Y230|RUVB2_HUMAN RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3
MATVTATTKVPEIRDVTRIERIGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVL
EMIREGKIAGRAVLIAGQPGTGKTAIAMGMAQALGPDTPFTAIAGSEIFSLEMSKTEALT
QAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKMIE
SLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVH
TVSLHEIDVINSRTQGFLALFSGDTGEIKSEVREQINAKVAEWREEGKAEIIPGVLFIDE
VHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVSTT
PYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTE
VQVDDIKRVYSLFLDESRSTQYMKEYQDAFLFNELKGETMDTS" |
| Structure Information |
| PDB ID | 2CQA |
| Quaternary structure | hexameric rings |
| SCOP | "80268212CQA A:8-89
80392002CQA A:8-89" |
| CATH | 2.40.50.360 |
| TM Helix Prediction | 0 |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | ATPase component of chromatin remodeling complexes |
| References for function | _ |
| E.C. number | EC:3.6.4.12 |
| Location of functional site(s) | |
| Cellular location of function | nucleus, with chromatin |
| Comments | |
| Function 2 |
| Function description | localizes to midbody during cell division |
| References for function | Messina G, Prozzillo Y, Monache FD, Santopietro MV, Dimitri P. Evolutionary conserved relocation of chromatin remodeling complexes to the mitotic apparatus. BMC Biol. 2022 Aug 3;20(1):172. doi: 10.1186/s12915-022-01365-5. PMID: 35922843; PMCID: PMC9351137. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | localizes to midbody during cell division |
| Comments | |