| General Information |
| MoonProt ID | 4105 |
| First appeared in release | 4.0 |
| Name(s) | Pyruvate kinase |
| UniProt ID | G7SG55 |
| GO terms | "GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
GO:0006096 glycolytic process" |
| Organisms for which functions have been demonstrated | Streptococcus suis |
| Sequence length | 501.0 |
| FASTA sequence | ">tr|G7SG55|G7SG55_STRSU Pyruvate kinase OS=Streptococcus suis D12 OX=1004952 GN=SSUD12_1393 PE=3 SV=1
MNKRVKIVATLGPAVEIRGGKKFGDDGYWGEKLDVESSAQKIAALITEGANVFRFNFSHGDHQEQGDRMATVRRAEEIAGKKVGFLLDTKGPEIRTELFEDDAKEYAYTTGDKLRVATKQGIKSTKEVIALNVAGGLDVFDDVEVGKQILVDDGKLGLTVVEKDAVNREFVVLVENDGVIAKQKGVNIPYTKIPFPALAERDNADIRFGLEQGLNFIAISFVRTAKDVEVVRNICKETGNDHVQLFAKIENQQGIDNIDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKAVITATNMLETMTEKPRATRSEVSDVFNAVIDGTDATMLSGESANGKYPVESVRTMATIAKNAQTLLNEYGRLNSDHFNRASKTEVIASAVKDACHSMNIKLVVTVTETGYSARSISKYRPDADILAVTFTEKVQKSLMLNWGVIPVVTNRPDSTDDMFDLAERIAKEQGLVEAGDDIIIVAGVPVGVAGSTNTMRVRTVK" |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | homotetramer |
| SCOP | |
| CATH | |
| TM Helix Prediction | 0 |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, Pyruvate kinase, converts ADP + phosphoenolpyruvate => ATP + pyruvate, Carbohydrate degradation, glycolysis |
| References for function | _ |
| E.C. number | 2.7.1.40 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds host collagene type I and fibronectin |
| References for function | Zhang, H., Zheng, J., Yi, L. et al. The identification of six novel proteins with fibronectin or collagen type I binding activity from Streptococcus suis serotype 2. J Microbiol. 52, 963–969 (2014). https://doi.org/10.1007/s12275-014-4311-x |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | Cell surface |
| Comments | |