| General Information |
| MoonProt ID | 411 |
| First appeared in release | 3.0 |
| Name(s) | Breast cancer type 1 susceptibility protein, gene: BRCA1 |
| UniProt ID | P38398 |
| GO terms | GO:0006301 postreplication repair
GO:0016567 protein ubiquitination
GO:0000724 double-strand break repair via homologous recombination
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0006302 double-strand break repair
GO:0005634 nucleus
GO:0004842 ubiquitin-protein transferase activity
GO:0009048 dosage compensation by inactivation of X chromosome
GO:0031436 BRCA1-BARD1 complex
GO:0035067 negative regulation of histone acetylation
GO:0043009 chordate embryonic development
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0070531 BRCA1-A complex
GO:0000724 double-strand break repair via homologous recombination
GO:0005886 plasma membrane
GO:0035066 positive regulation of histone acetylation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0071158 positive regulation of cell cycle arrest
GO:0070063 RNA polymerase binding
GO:0070531 BRCA1-A complex
GO:0004842 ubiquitin-protein transferase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0085020 protein K6-linked ubiquitination
GO:0051865 protein autoubiquitination
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0031625 ubiquitin protein ligase binding
GO:0072425 signal transduction involved in G2 DNA damage checkpoint
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0045739 positive regulation of DNA repair
GO:0010212 response to ionizing radiation
GO:0006302 double-strand break repair
GO:0005694 chromosome
GO:0005515 protein binding
GO:0004842 ubiquitin-protein transferase activity
GO:0006281 DNA repair
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0006974 cellular response to DNA damage stimulus
GO:0046872 metal ion binding
GO:0016740 transferase activity
GO:0006633 fatty acid biosynthetic process
GO:0006281 DNA repair
GO:0006631 fatty acid metabolic process
GO:0003677 DNA binding
GO:0005694 chromosome
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0005634 nucleus
GO:0006629 lipid metabolic process
GO:0007049 cell cycle
GO:0005737 cytoplasm
GO:0003677 DNA binding
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006974 cellular response to DNA damage stimulus
GO:0008270 zinc ion binding
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0003723 RNA binding
GO:1990904 ribonucleoprotein complex
GO:0032991 protein-containing complex
GO:0000800 lateral element
GO:0000729 DNA double-strand break processing
GO:0016579 protein deubiquitination
GO:1901796 regulation of signal transduction by p53 class mediator
GO:0005654 nucleoplasm
GO:0006260 DNA replication
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0070317 negative regulation of G0 to G1 transition
GO:0042802 identical protein binding
GO:0005515 protein binding
GO:0070512 positive regulation of histone H4-K20 methylation
GO:0051573 negative regulation of histone H3-K9 methylation
GO:0051572 negative regulation of histone H3-K4 methylation
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0044818 mitotic G2/M transition checkpoint
GO:0043009 chordate embryonic development
GO:0035067 negative regulation of histone acetylation
GO:0009048 dosage compensation by inactivation of X chromosome
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000794 condensed nuclear chromosome
GO:2000620 positive regulation of histone H4-K16 acetylation
GO:2000617 positive regulation of histone H3-K9 acetylation
GO:0051574 positive regulation of histone H3-K9 methylation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0044030 regulation of DNA methylation
GO:0035066 positive regulation of histone acetylation
GO:0007098 centrosome cycle
GO:0006974 cellular response to DNA damage stimulus
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006302 double-strand break repair
GO:0005737 cytoplasm
GO:0005694 chromosome
GO:0003684 damaged DNA binding
GO:0000793 condensed chromosome
GO:0004842 ubiquitin-protein transferase activity
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors P
GO:0071356 cellular response to tumor necrosis factor
GO:0010628 positive regulation of gene expression
GO:2000378 negative regulation of reactive oxygen species metabolic process P
GO:0045766 positive regulation of angiogenesis
GO:0010575 positive regulation of vascular endothelial growth factor production P
GO:0051573 negative regulation of histone H3-K9 methylation
GO:0070512 positive regulation of histone H4-K20 methylation
GO:0005886 plasma membrane
GO:0035066 positive regulation of histone acetylation
GO:0071158 positive regulation of cell cycle arrest
GO:2000617 positive regulation of histone H3-K9 acetylation
GO:2000620 positive regulation of histone H4-K16 acetylation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005654 nucleoplasm
GO:0016604 nuclear body
GO:0016567 protein ubiquitination
GO:0015631 tubulin binding
GO:0019899 enzyme binding
GO:0005515 protein binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0043627 response to estrogen
GO:0032991 protein-containing complex
GO:0031436 BRCA1-BARD1 complex
GO:0071681 cellular response to indole-3-methanol
GO:0031398 positive regulation of protein ubiquitination
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0042127 regulation of cell population proliferation
GO:0008274 gamma-tubulin ring complex
GO:0000151 ubiquitin ligase complex
GO:0046600 negative regulation of centriole replication
GO:0042981 regulation of apoptotic process
GO:0007059 chromosome segregation
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator P
GO:0006915 apoptotic process
GO:0006359 regulation of transcription by RNA polymerase III
GO:0005515 protein binding
|
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 1,863 amino acids |
| FASTA sequence | >sp|P38398|BRCA1_HUMAN Breast cancer type 1 susceptibility protein OS=Homo sapiens OX=9606 GN=BRCA1 PE=1 SV=2
MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVEKAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCERKEWNKQKLPCSENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNAKVADVLDVLNEVDEYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRKKASLPNLSHVTENLIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQKTPEMINQGTNQTEQNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPISSSISNMELELNIHNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPVRHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKEFVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHSRETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVTFECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRFCLSSQFRGNETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIPSTVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDENIQAELGRNRGPKLNAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSSHASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQGYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENLLSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGSSKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIPHSHY |
| Structure Information |
| PDB ID | 3K0H, 1JNX, 3PXE, 3PXB, 1T2U, 6G2I, 3K15, 4Y18, 3PXC, 1N5O, 3COJ, 3PXD, 3PXA, 4JLU, 2ING, 1OQA, 1JM7 |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | 3.40.50.10190 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | 82.9% |
| Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
moonID_411_uniID_P38398 is 1863 residues long, with 1649 residues (88.51%) predicted as disordered.The protein has 4 short (< 30 residues) disorder segments and 2 long (>= 30 residues) disorder segments.
Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 1 and 4 in the sequence. The segment is 4 residues long (0.21 % of the total sequence length).
Segment 2 - Short (< 30 residues) disordered segment Segment is located between positions 60 and 71 in the sequence. The segment is 12 residues long (0.64 % of the total sequence length).
Segment 3 - Long (>= 30 residues) disordered segment Segment is located between positions 97 and 1658 in the sequence. The segment is 1562 residues long (83.84 % of the total sequence length).
Segment 4 - Long (>= 30 residues) disordered segment Segment is located between positions 1730 and 1766 in the sequence. The segment is 37 residues long (1.99 % of the total sequence length).
Segment 5 - Short (< 30 residues) disordered segment Segment is located between positions 1798 and 1819 in the sequence. The segment is 22 residues long (1.18 % of the total sequence length).
Segment 6 - Short (< 30 residues) disordered segment Segment is located between positions 1852 and 1863 in the sequence. The segment is 12 residues long (0.64 % of the total sequence length). |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | associates with RNA polymerase II holoenzyme and some transcription factors, including TFIIF/GTF2F1, TFIIE/GTF2E1, and TFIIH/GTF2H1, acting as a transcription regulator |
| References for function | 9159119 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | nucleus |
| Comments | NA |
| Function 2 |
| Function description | interacts with the BRCA1-associated RING domain protein (BARD1) and the Obg-like ATPase (OLA1), forming a complex with E3 ligase activity that binds and ubiquinates gamma-tubulin |
| References for function | 9789027 |
| E.C. number | 2.3.2.27 |
| Location of functional site(s) | NA |
| Cellular location of function | centrosome; nucleus |
| Comments | causes centrosome amplification and fragmentation in cell lines from mammary tissues and in mouse embryonic fibroblast cells; data suggests that BRCA1 is directly involved in centrosome maintenance |