| General Information |
| MoonProt ID | 4110 |
| First appeared in release | 4.0 |
| Name(s) | Inosine-5'-monophosphate dehydrogenase |
| UniProt ID | A0A6L8MX07 |
| GO terms | "GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process" |
| Organisms for which functions have been demonstrated | Streptococcus suis |
| Sequence length | 493.0 |
| FASTA sequence | ">tr|A0A6L8MX07|A0A6L8MX07_STRSU Inosine-5'-monophosphate dehydrogenase OS=Streptococcus suis OX=1307 GN=guaB PE=3 SV=1
MSNWDTKFLKKGFTFDDVLLIPAESHVLPHDIDLKTQLAPNLTLNLPIISAAMDTVTDSKMAIAMARAGGLGVIHKNMSIAEQADEVRKVKRSENGVIIDPFFLTPEHTIAEAEKLMATYRISGVPIVETLENRKLVGIITNRDMRFISDYSQPISTNMTSDALVTAPVGTDLATAEAILHKHRIEKLPLVDENGRLSGLITIKDIEKVIEFPNAAKDEFGRLLVAGAVGVTSDTFERAEALFEAGADAIVIDTAHGHSAGVLRKIKEIREHFPTRTLIAGNIATAEGARALYEAGVDVVKVGIGPGSICTTRVIAGVGVPQVTAIYDAAGVAREYGKTIIADGGIKYSGDIVKALAAGGHAVMLGSMFAGTDEAPGETEIFQGRKFKTYRGMGSIAAMKQGSKDRYFQASVNEANKLVPEGIEGRVAYKGSVADMIFQMVGGLRSGMGYVGAGNLNELHENAQFIEMSGAGLKESHPHDVQITNEAPNYSVQ" |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | homotetramer |
| SCOP | |
| CATH | |
| TM Helix Prediction | 0 |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, inosine 5-monophosphate dehydrogenase, catalyzes the irreversible NADPH-dependent deamination of GMP to IMP; Purine metabolism; XMP biosynthesis (uniprot) |
| References for function | _ |
| E.C. number | 1.1.1.205 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds host collagene type I |
| References for function | Zhang, H., Zheng, J., Yi, L. et al. The identification of six novel proteins with fibronectin or collagen type I binding activity from Streptococcus suis serotype 2. J Microbiol. 52, 963–969 (2014). https://doi.org/10.1007/s12275-014-4311-x |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |