| General Information |
| MoonProt ID | 415 |
| First appeared in release | 3.0 |
| Name(s) | ADP/ATP translocase 2 or Adenine nucleotide translocator 2 |
| UniProt ID | P51881 |
| GO terms | GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0071817 MMXD complex
GO:0005347 ATP transmembrane transporter activity
GO:0005471 ATP:ADP antiporter activity
GO:1990544 mitochondrial ATP transmembrane transport
GO:0005743 mitochondrial inner membrane
GO:0055085 transmembrane transport
GO:0140021 mitochondrial ADP transmembrane transport
GO:0007059 chromosome segregation
GO:0016020 membrane
GO:0005743 mitochondrial inner membrane
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
GO:0031625 ubiquitin protein ligase binding
GO:0000295 adenine nucleotide transmembrane transporter activity
GO:0005743 mitochondrial inner membrane
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:0045121 membrane raft
GO:0042645 mitochondrial nucleoid
GO:0008284 positive regulation of cell population proliferation
GO:1990830 cellular response to leukemia inhibitory factor
GO:0071817 MMXD complex
GO:0051503 adenine nucleotide transport
GO:0016020 membrane
GO:0005743 mitochondrial inner membrane
GO:0005739 mitochondrion
GO:0000295 adenine nucleotide transmembrane transporter activity
GO:0005739 mitochondrion
GO:0051503 adenine nucleotide transport
GO:0071817 MMXD complex
GO:0005743 mitochondrial inner membrane
GO:0008284 positive regulation of cell population proliferation
GO:0031625 ubiquitin protein ligase binding
GO:0042645 mitochondrial nucleoid
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:0045121 membrane raft
GO:0005743 mitochondrial inner membrane
GO:0043209 myelin sheath |
| Organisms for which functions have been demonstrated | Mus musculus (Mouse, mammal) |
| Sequence length | 298 amino acids |
| FASTA sequence | >sp|P51881|ADT2_MOUSE ADP/ATP translocase 2 OS=Mus musculus OX=10090 GN=Slc25a5 PE=1 SV=3
MTDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKAGAEREFKGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAYFGIYDTAKGMLPDPKNTHIFISWMIAQSVTAVAGLTSYPFDTVRRRMMMQSGRKGTDIMYTGTLDCWRKIARDEGSKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT |
| Structure Information |
| PDB ID | closest s from Bos taurus |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | 2(112-134,209-231) |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | NA |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | mediates transmembrane exchange of ADP and ATP, providing ADP to the mitochondrial ATPase (complex V) |
| References for function | 31618756 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | Mitochondrion inner membrane |
| Comments | NA |
| Function 2 |
| Function description | ANT promotes mitophagy independently of its ADP/ATP exchange activity |
| References for function | 31618756 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | Mitochondrion inner membrane |
| Comments | NA |