| General Information |
| MoonProt ID | 417 |
| First appeared in release | 3.0 |
| Name(s) | Core-binding factor subunit beta, CBFB, CBF-beta, Polyomavirus enhancer-binding protein 2 beta subunit,
PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit |
| UniProt ID | Q13951 |
| GO terms | GO:0003713 transcription coactivator activity
GO:0006366 transcription by RNA polymerase II
GO:0030111 regulation of Wnt signaling pathway
GO:0045637 regulation of myeloid cell differentiation
GO:2000810 regulation of bucellular tight junction assembly
GO:0001959 regulation of cytosine-mediated signaling pathway |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 182 amino acids |
| FASTA sequence | >sp|Q13951|PEBB_HUMAN Core-binding factor subunit beta OS=Homo sapiens OX=9606 GN=CBFB PE=1 SV=2
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTTRP |
| Structure Information |
| PDB ID | 4N9F_0 |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | NA |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | non-DNA-binding regulatory subunit; binds RUNX (RUNX1, RUNX2, or RUNX3) to form different versions of CBF; it allosterically enhances the sequence-specific DNA-binding capacity of RUNX |
| References for function | 24648201 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | nucleus |
| Comments | NA |
| Function 2 |
| Function description | Also binds RUNX & binds with mitotic proteins MRLC3; allows for completion of cytokinesis |
| References for function | 24648201 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | Midbody FR |
| Comments | RNAi-mediated depletion of CBF beta or overexpression of the CBF beta-SMMHC leads to defective midbody structure and cytokinesis (abscission); polyploid cells |