Protein Information

General Information
MoonProt ID419
First appeared in release3.0
Name(s)Glutathione reductase
UniProt IDQ59NQ5
GO termsGO:0004362 glutathione-disulfide reductase activity GO:0045454 cell redox homeostasis GO:0009405 pathogenesis GO:0034599 cellular response to oxidative stress GO:0005829 cytosol GO:0050660 flavin adenine dinucleotide binding GO:0005739 mitochondrion GO:0006749 glutathione metabolic process GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor GO:0050661 NADP binding GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity GO:0005737 cytoplasm GO:0000166 nucleotide binding GO:0098869 cellular oxidant detoxification
Organisms for which functions have been demonstratedCandida albicans (yeast, a fungi, can cause candiadiasis)
Sequence length516 amino acids
FASTA sequence>tr|Q59NQ5|Q59NQ5_CANAL Glutathione reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=GLR1 PE=3 SV=1 MFTNSIISKSTTRLTQLSRQLSTTTMAPTSTKNSIKHFDYLVIGGGSGGVASARRAAKYGAKVLLIESNFKKFGGTCVNVGCVPKKVMWYTADLAHKKHDLYAYGLDKEPDSIKYGDFDWAKLKHKRDAYVTRLNGIYENNLKREKVDYAYGFAKFINSEGEVEVTLSGDQELPFLDEGKTYKKGEKLVFSADKTLIATGGTAIVPPSVPGAELGTTSDGFFALEKQPKKVAIVGAGYIGVELSGVFSSLGSETHFFIRGDTVLRSFDEVIQNTVTDYYIDNLGINIHKQSTITKIEGSKDGKKVVHLKDGTSVEVDELIWTVGRKSLIDIGLDKVDVKINDKQQIVADEYQVTNNPKIFSLGDVVGKVELTPVAIAAGRRLSNRLFGGPEFAKDKLDYNNIPSVIFSHPEAGSIGLSTKEAIEKYGEENLKIYQSKFTAMYYAMMDDQKDKSPTVYKIICAGPEEKVVGLHIVGDSSAEILQGFGVAIKMGATKKDFDNCVAIHPTSAEELVTMT
Structure Information
PDB ID2HQM
Quaternary structureNA
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder RegionsUse FASTA sequence on the MFDp2 webserver. moonID_419_uniID_Q59NQ5 is 516 residues long, with 11 residues (2.13%) predicted as disordered.The protein has 1 short (< 30 residues) disorder segment and 0 long (>= 30 residues) disorder segments. Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 1 and 11 in the sequence. The segment is 11 residues long (2.13 % of the total sequence length).
Connections to Disease
OMIM ID
Function 1
Function descriptionReductase Activity
References for function10844651
E.C. number1.8.1.7
Location of functional site(s)NA
Cellular location of functioncytoplasm
Commentsinvolved in Redox Homeostasis
Function 2
Function descriptionBinding to plasma proteins
References for function29223801
E.C. numberNA
Location of functional site(s)NA
Cellular location of functioncell surface
Commentscommon function found in several Candida species