General Information |
MoonProt ID | 419 |
First appeared in release | 3.0 |
Name(s) | Glutathione reductase |
UniProt ID | Q59NQ5 |
GO terms | GO:0004362 glutathione-disulfide reductase activity
GO:0045454 cell redox homeostasis
GO:0009405 pathogenesis
GO:0034599 cellular response to oxidative stress
GO:0005829 cytosol
GO:0050660 flavin adenine dinucleotide binding
GO:0005739 mitochondrion
GO:0006749 glutathione metabolic process
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050661 NADP binding
GO:0055114 oxidation-reduction process
GO:0016491 oxidoreductase activity
GO:0005737 cytoplasm
GO:0000166 nucleotide binding
GO:0098869 cellular oxidant detoxification |
Organisms for which functions have been demonstrated | Candida albicans (yeast, a fungi, can cause candiadiasis) |
Sequence length | 516 amino acids |
FASTA sequence | >tr|Q59NQ5|Q59NQ5_CANAL Glutathione reductase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=GLR1 PE=3 SV=1
MFTNSIISKSTTRLTQLSRQLSTTTMAPTSTKNSIKHFDYLVIGGGSGGVASARRAAKYGAKVLLIESNFKKFGGTCVNVGCVPKKVMWYTADLAHKKHDLYAYGLDKEPDSIKYGDFDWAKLKHKRDAYVTRLNGIYENNLKREKVDYAYGFAKFINSEGEVEVTLSGDQELPFLDEGKTYKKGEKLVFSADKTLIATGGTAIVPPSVPGAELGTTSDGFFALEKQPKKVAIVGAGYIGVELSGVFSSLGSETHFFIRGDTVLRSFDEVIQNTVTDYYIDNLGINIHKQSTITKIEGSKDGKKVVHLKDGTSVEVDELIWTVGRKSLIDIGLDKVDVKINDKQQIVADEYQVTNNPKIFSLGDVVGKVELTPVAIAAGRRLSNRLFGGPEFAKDKLDYNNIPSVIFSHPEAGSIGLSTKEAIEKYGEENLKIYQSKFTAMYYAMMDDQKDKSPTVYKIICAGPEEKVVGLHIVGDSSAEILQGFGVAIKMGATKKDFDNCVAIHPTSAEELVTMT |
Structure Information |
PDB ID | 2HQM |
Quaternary structure | NA |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
moonID_419_uniID_Q59NQ5 is 516 residues long, with 11 residues (2.13%) predicted as disordered.The protein has 1 short (< 30 residues) disorder segment and 0 long (>= 30 residues) disorder segments.
Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 1 and 11 in the sequence. The segment is 11 residues long (2.13 % of the total sequence length). |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Reductase Activity |
References for function | 10844651 |
E.C. number | 1.8.1.7 |
Location of functional site(s) | NA |
Cellular location of function | cytoplasm |
Comments | involved in Redox Homeostasis |
Function 2 |
Function description | Binding to plasma proteins |
References for function | 29223801 |
E.C. number | NA |
Location of functional site(s) | NA |
Cellular location of function | cell surface |
Comments | common function found in several Candida species |