| General Information |
| MoonProt ID | 42 |
| First appeared in release | 1.0 |
| Name(s) | Enolase
Alpha-enolase
2-phospho-D-glycerate hydro-lyase
Enolase 1
Non-neural enolase
NNE |
| UniProt ID | P04764 (ENOA_RAT), Reviewed |
| GO terms | GO:0006096 glycolysis
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0000015 phosphopyruvate hydratase complex
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043005 neuron projection
GO:0097060 synaptic membrane |
| Organisms for which functions have been demonstrated | Rattus norvegicus (rat, a mammal) |
| Sequence length | 434 |
| FASTA sequence | >sp|P04764|ENOA_RAT Alpha-enolase OS=Rattus norvegicus GN=Eno1 PE=1 SV=4
MSILKIHAREIFDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDNDKTRFMGKGVSKAVEHINKTIAPALVSKKLNVVEQEKIDQLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNPEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGASSFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKSAIAKAGYTDQVVIGMDVAASEFYRAGKYDLDFKSPDDASRYITPDQLADLYKSFIKDYPVVSIEDPFDQDDWDAWQKFTATAGIQVVGDDLTVTNPKRIAKAAGEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNPLAK
|
| Structure Information |
| PDB ID | closest is human at 94% |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1--3 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Carbohydrate degradation, glycolysis
|
| References for function | |
| E.C. number | 4.2.1.11 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | plasminogen binding |
| References for function | Nakijama, K., Hamanoue, M., Takemoto, N., Hattori, T., Kato, K. & Kohsaka, S. (1994). Plasminogen binds specifically to a alpha-enolase on rat neuronal plasma membrane. J Neurochem. 1994 Dec;63(6):2048-57.
PMID: 7964722 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |