| General Information |
| MoonProt ID | 424 |
| First appeared in release | 3.0 |
| Name(s) | OCT1, POU2F1, POU domain, class 2, transcription factor 1, octamer binding protein 1 |
| UniProt ID | P14859 |
| GO terms | GO:0045944
GO:0000981
GO:0000790
GO:0030154
GO:0001228
GO:0045944
GO:0005634
GO:0003700
GO:0000981
GO:0003677
GO:0005634
GO:0006355
GO:0003677
GO:0005634
GO:0003677
GO:0005634
GO:0005634
GO:0045892
GO:0043565
GO:0043565
GO:0005654
GO:0005654
GO:0005654
GO:0005654
GO:0005654
GO:0005654
GO:0005654
GO:0005654
GO:0005654
GO:0005654
GO:0005654
GO:0005654
GO:0005654
GO:0005654
GO:0005654
GO:0019221
GO:0042795
GO:0005515
GO:0005515
GO:0005515
GO:0005515
GO:0005515
GO:0005634
GO:0005783
GO:0005654
GO:0043231
GO:0003677
GO:0000978
GO:0000978
GO:0000978
GO:0000979
GO:0090575
GO:0090575
GO:0000981
GO:0045944
GO:0045944
GO:0045944
GO:0043565
GO:0005515
GO:0005515
GO:0005515
GO:0005515
GO:0045892
GO:0042802
GO:0005515
GO:0005515
GO:0005515
GO:0005515
GO:0005515
GO:0005515
GO:0005515
GO:0005515
GO:0005515
GO:0005515
GO:0005515
GO:0005515
GO:0005515
GO:0005515
GO:0005515
GO:0005515 |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 743 amino acids |
| FASTA sequence | >sp|P14859|PO2F1_HUMAN POU domain, class 2, transcription factor 1 OS=Homo sapiens OX=9606 GN=POU2F1 PE=1 SV=2
MNNPSETSKPSMESGDGNTGTQTNGLDFQKQPVPVGGAISTAQAQAFLGHLHQVQLAGTSLQAAAQSLNVQSKSNEESGDSQQPSQPSQQPSVQAAIPQTQLMLAGGQITGLTLTPAQQQLLLQQAQAQAQLLAAAVQQHSASQQHSAAGATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQQFVLVHPTTNLQPAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPIQTLPQSQSTPKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENLSSDSSLSSPSALNSPGIEGLSRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEK
EVIRVWFCNRRQKEKRINPPSSGGTSSSPIKAIFPSPTSLVATTPSLVTSSAATTLTVSP
VLPLTSAAVTNLSVTGTSDTTSNNTATVISTAPPASSAVTSPSLSPSPSASASTSEASSA
SETSTTQTTSTPLSSPLGTSQVMVTASGLQTAAAAALQGAAQLPANASLAAMAAAAGLNP
SLMAPSQFAAGGALLSLNPGTLSGALSPALMSNSTLATIQALASGGSLPITSLDATGNLV
FANAGGAPNIVTAPLFLNPQNLSLLTSNPVSLVSAAAASAGNSAPVASLHATSTSAESIQ
NSLFTVASASGAASTTTTASKAQ |
| Structure Information |
| PDB ID | 1CQT |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | 30.3%, 1-200, 355-379 |
| Predicted Disorder Regions | NA |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. |
| References for function | 2014164 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | nucleus |
| Comments | NA |
| Function 2 |
| Function description | Interacts with BRCA1, binds PARP-1 and APC1 |
| References for function | 15563594 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | Centrosomes, kinetochores and midbody DZ |
| Comments | Abnormal mitosis; unknown function at the midbody |