Protein Information

General Information
MoonProt ID425
First appeared in release3.0
Name(s)Peroxiredoxin 2; Prx2, Thioredoxin peroxidase; Thioredoxin peroxidase 2; gene: TPx-2
UniProt IDQ9Y0D3
GO termsGO:0055114 oxidation-reduction process GO:0016209 antioxidant activity GO:0016491 oxidoreductase activity GO:0051920 peroxiredoxin activity GO:0098869 cellular oxidant detoxification
Organisms for which functions have been demonstratedSchistosoma mansoni, blook fluke
Sequence length194 amino acids
FASTA sequence>tr|Q9Y0D3|Q9Y0D3_SCHMA Peroxiredoxin, Prx2 OS=Schistosoma mansoni OX=6183 GN=TPx-2 PE=2 SV=1 MLLPNQPAPDFEGTAVIGTELRPISLSQFQGKYVLLVFYPLDFTFVCPTELIAFSERAAEFQSRGCQVIACSTDSVYAHLAWTKLDRKAGGLGQMNIPLLSDKNLRISRAYEVLDEQEGHAFRGMFLIDRKGILRQITVNDRPVGRSVDEAIRLLDAFIFFEKHGEVCPANWKPNSATIKPDPVASLSYFSSVH
Structure Information
PDB IDNone, but close homologue to Prx1 with 67.22% amino acid sequence identity
Quaternary structuredimeric structure
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder RegionsUse FASTA sequence on the MFDp2 webserver. moonID_425_uniID_Q9Y0D3 is 194 residues long, with 0 residues (0.00%) predicted as disordered.The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments.
Connections to Disease
OMIM ID
Function 1
Function descriptionPeroxiredoxin
References for function1.11.1.15
E.C. numberNA
Location of functional site(s)Cysteine sulfenic acid (-SOH) intermediate
Cellular location of functioncytoplasm
Commentshigher level of Prx found in SEA compared to SWAP
Function 2
Function descriptionregulator of host Th2 modulated immune response when secreted
References for functionNA
E.C. numberNA
Location of functional site(s)NA
Cellular location of functionsecreted by cells
Commentsinduces the expression of Ym1 in macrophages independent of antioxidant activity, induces development of Th2 immune responses, the abundance of Prx2 correlates with the ability to induce Ym1 expression and promote polarized Th2 immune responses, the removal of enzyme activity has no effect on this functionality, antioxidant can function without cytokine stimulation