| General Information |
| MoonProt ID | 43 |
| First appeared in release | 1.0 |
| Name(s) | enolase
Gene Name: ENO |
| UniProt ID | Q3HL75 (Q3HL75_LEIME), Unreviewed |
| GO terms | GO:0006096 glycolysis
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0000015 phosphopyruvate hydratase complex |
| Organisms for which functions have been demonstrated | Leishmania mexicana (causes human leishmaniasis) |
| Sequence length | 429 |
| FASTA sequence | >gi|77176833|gb|ABA64522.1| enolase [Leishmania mexicana]
MPILKIHAREVLDSRGNPTVEVELTTEAGVFRSAVPSGASTGVHEACELRDGDKARYCGAGCTQAVKYVNEILAPALVGKDESDQAGLDKLMCELDGTKNKSKLGANAILGCSMAISKAAAAKAGVPLYRYIAGLAGTKDMRLPVPCFNVINGGKHAGNVLPFQEFMIAPTKATSFREALRMGSEVYHALKGIIKGKYGQDAVNVGDEGGFAPPIKQIDEPLPILMEAIEKAGHKGKFAICMDCAASEAYDAERKMYNLTFKNPEPTYVSAAKLQETYERWVSEYPLVSIEDPFAEDNFDEFSAITKALAGKAQIVGDDLTVTNVERVKMAIDKSACNSLLLKINQIGTISESIAAAKLCMENGWSVMVSHRSGETEDTYIADLSVGLGTGQIKTGAPCRGERTAKLNQLLRIEEEMGSAAKYGYPGWA |
| Structure Information |
| PDB ID | closest is Trypanosoma at 74% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-3,429-434 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enolase, enzyme
reversible conversion of 2-phosphoglycerate to phosphoenolpyruvate |
| References for function | |
| E.C. number | 4.2.1.11 |
| Location of functional site(s) | |
| Cellular location of function | cytosol |
| Comments | |
| Function 2 |
| Function description | binds plasminogen |
| References for function | Vanegas G, Qui?ones W, CarrascoL?pez C, Concepci?n JL, Albericio F, Avil?n L. Enolase as a plasminogen binding protein in Leishmania mexicana. Parasitol Res. 2007 Nov;101(6):1511-6. Epub 2007 Jul 27.
PMID: 17653767 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |