General Information |
MoonProt ID | 433 |
First appeared in release | 3.0 |
Name(s) | Thioredoxin peroxidase |
UniProt ID | P91883 |
GO terms | GO:0055114 oxidation-reduction process
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0051920 peroxiredoxin activity
GO:0004601 peroxidase activity
GO:0098869 cellular oxidant detoxification |
Organisms for which functions have been demonstrated | Fasciola hepatica |
Sequence length | 194 amino acids |
FASTA sequence | >sp|P91883|TDX_FASHE Thioredoxin peroxidase OS=Fasciola hepatica OX=6192 PE=2 SV=1 MLQPNMPAPNFSGQAVVGKEFETISLSDYKGKWVILAFYPLDFTFVCPTEIIAISDQMEQFAQRNCAVIFCSTDSVYSHLQWTKMDRKVGGIGQLNFPLLADKNMSVSRAFGVLDEEQGNTYRGNFLIDPKGVLRQITVNDDPVGRSVEEALRLLDAFIFHEEHGEVCPANWKPKSKTIVPTPDGSKAYFSSAN |
Structure Information |
PDB ID | NA |
Quaternary structure | monomer |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
moonID_433_uniID_P91883 is 194 residues long, with 14 residues (7.22%) predicted as disordered.The protein has 1 short (< 30 residues) disorder segment and 0 long (>= 30 residues) disorder segments.
Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 181 and 194 in the sequence. The segment is 14 residues long (7.22 % of the total sequence length). |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Thioredoxin peroxidase, protection against ROS, antioxidant, oxidoreductase |
References for function | 15618151 |
E.C. number | 1.11.1.24 |
Location of functional site(s) | NA |
Cellular location of function | cytoplasm |
Comments | NA |
Function 2 |
Function description | cytokine, Regulates alternative activation of macrophages, inducing Th2 response |
References for function | 15618151 |
E.C. number | NA |
Location of functional site(s) | NA |
Cellular location of function | Extracellular (secreted) |
Comments | NA |