Protein Information

General Information
MoonProt ID444
First appeared in release3.0
Name(s)58 kDa microspherule protein Cell cycle-regulated factor p78 INO80 complex subunit J MCRS2
UniProt IDQ96EZ8 (MCRS1_HUMAN)
GO termsGO:0000123 histone acetyltransferase complex GO:0002151 G-quadruplex RNA binding GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005730 nucleolus GO:0005737 cytoplasm GO:0005783 endoplasmic reticulum GO:0005844 polysome GO:0006281 DNA repair GO:0006310 DNA recombination GO:0006325 chromatin organization GO:0006464 cellular protein modification process GO:0006974 cellular response to DNA damage stimulus GO:0008266 poly(U) RNA binding GO:0010521 telomerase inhibitor activity GO:0016032 viral process GO:0016579 protein deubiquitination GO:0030425 dendrite GO:0031011 Ino80 complex GO:0034046 poly(G) binding GO:0043204 perikaryon GO:0043981 histone H4-K5 acetylation GO:0043982 histone H4-K8 acetylation GO:0043984 histone H4-K16 acetylation GO:0043995 histone acetyltransferase activity (H4-K5 specific) GO:0043996 histone acetyltransferase activity (H4-K8 specific) GO:0044545 NSL complex GO:0045944 positive regulation of transcription by RNA polymerase II GO:0046972 histone acetyltransferase activity (H4-K16 specific) GO:0051974 negative regulation of telomerase activity GO:0071339 MLL1 complex GO:1904357 negative regulation of telomere maintenance via telomere lengthening GO:1904751 positive regulation of protein localization to nucleolus
Organisms for which functions have been demonstratedHomo sapiens (human, a mammal)
Sequence length462 amino acids
FASTA sequence>sp|Q96EZ8|MCRS1_HUMAN Microspherule protein 1 OS=Homo sapiens OX=9606 GN=MCRS1 PE=1 SV=1 MDKDSQGLLDSSLMASGTASRSEDEESLAGQKRASSQALGTIPKRRSSSRFIKRKKFDDE LVESSLAKSSTRAKGASGVEPGRCSGSEPSSSEKKKVSKAPSTPVPPSPAPAPGLTKRVK KSKQPLQVTKDLGRWKPADDLLLINAVLQTNDLTSVHLGVKFSCRFTLREVQERWYALLY DPVISKLACQAMRQLHPEAIAAIQSKALFSKAEEQLLSKVGSTSQPTLETFQDLLHRHPD AFYLARTAKALQAHWQLMKQYYLLEDQTVQPLPKGDQVLNFSDAEDLIDDSKLKDMRDEV LEHELMVADRRQKREIRQLEQELHKWQVLVDSITGMSSPDFDNQTLAVLRGRMVRYLMRS REITLGRATKDNQIDVDLSLEGPAWKISRKQGVIKLKNNGDFFIANEGRRPIYIDGRPVL CGSKWRLSNNSVVEIASLRFVFLINQDLIALIRAEAAKITPQ
Structure Information
PDB IDNone
Quaternary structureNA
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder RegionsUse FASTA sequence on the MFDp2 webserver. moonID_444_uniID_Q96EZ8 is 462 residues long, with 141 residues (30.52%) predicted as disordered.The protein has 1 short (< 30 residues) disorder segment and 1 long (>= 30 residues) disorder segment. Segment 1 - Long (>= 30 residues) disordered segment Segment is located between positions 1 and 136 in the sequence. The segment is 136 residues long (29.44 % of the total sequence length). Segment 2 - Short (< 30 residues) disordered segment Segment is located between positions 458 and 462 in the sequence. The segment is 5 residues long (1.08 % of the total sequence length).
Connections to Disease
OMIM ID
Function 1
Function descriptionpart of the NSL complex, which acetylates nucleosomal histone H4 on lysine residues
References for function20018852
E.C. numberNA
Location of functional site(s)NA
Cellular location of functionnucleus
CommentsNA
Function 2
Function descriptioncomponent of KANSL complex located at Spindle poles; KANSL1 and KANSL3 bind MT minus ends
References for function22081094
E.C. numberNA
Location of functional site(s)NA
Cellular location of functionspindle poles
CommentsNA