Protein Information

General Information
MoonProt ID449
First appeared in release3.0
Name(s)Stromelysin-1, Matrix metalloproteinase-3, Transin-1 Gene: MMP3
UniProt IDP28862 (MMP3_MOUSE)
GO termsGO:0004175 endopeptidase activity GO:0004222 metalloendopeptidase activity GO:0005576 extracellular region GO:0005615 extracellular space GO:0005634 nucleus GO:0005739 mitochondrion GO:0005829 cytosol GO:0006508 proteolysis GO:0008233 peptidase activity GO:0008237 metallopeptidase activity GO:0008270 zinc ion binding GO:0010727 negative regulation of hydrogen peroxide metabolic process GO:0016787 hydrolase activity GO:0030163 protein catabolic process GO:0030198 extracellular matrix organization GO:0030334 regulation of cell migration GO:0030335 positive regulation of cell migration GO:0030425 dendrite GO:0030574 collagen catabolic process GO:0031012 extracellular matrix GO:0031334 positive regulation of protein-containing complex assembly GO:0032991 protein-containing complex GO:0044297 cell body GO:0044877 protein-containing complex binding GO:0046872 metal ion binding GO:0051898 negative regulation of protein kinase B signaling GO:0071230 cellular response to amino acid stimulus GO:1903209 positive regulation of oxidative stress-induced cell death
Organisms for which functions have been demonstratedMus musculus (Mouse, mammal)
Sequence length477 amino acids
FASTA sequence>sp|P28862|MMP3_MOUSE Stromelysin-1 OS=Mus musculus OX=10090 GN=Mmp3 PE=2 SV=2 MKGLPVLLWLCVVVCSSYPLHDSARDDDAGMELLQKYLENYYGLAKDVKQFIKKKDSSLIVKKIQEMQKFLGLEMTGKLDSNTMELMHKPRCGVPDVGGFSTFPGSPKWRKSHITYRIVNYTPDLPRQSVDSAIEKALKVWEEVTPLTFSRISEGEADIMISFAVGEHGDFVPFDGPGTVLAHAYAPGPGINGDAHFDDDERWTEDVTGTNLFLVAAHELGHSLGLYHSAKAEALMYPVYKSSTDLSRFHLSQDDVDGIQSLYGTPTASPDVLVVPTKSNSLEPETSPMCSSTLFFDAVSTLRGEVLFFKDRHFWRKSLRTPEPEFYLISSFWPSLPSNMDAAYEVTNRDTVFIFKGNQFWAIRGHEELAGYPKSIHTLGLPATVKKIDAAISNKEKRKTYFFVEDKYWRFDEKKQSMEPGFPRKIAEDFPGVDSRVDAVFEAFGFLYFFSGSSQLEFDPNAKKVTHILKSNSWFNC
Structure Information
PDB IDNA; closest has53% sequence identity, 1SU3_A
Quaternary structureNA
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder RegionsUse FASTA sequence on the MFDp2 webserver. moonID_449_uniID_P28862 is 477 residues long, with 0 residues (0.00%) predicted as disordered.The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments.
Connections to Disease
OMIM ID
Function 1
Function descriptionMetalloprotease (degrades fibronectin, gelatin, proteoglycans, denatured type I collagen, laminin, and other extracellular matrix components)
References for function26499805
E.C. numberNA
Location of functional site(s)NA
Cellular location of functioncell surface
CommentsNA
Function 2
Function descriptiontranscription factor
References for functionSi-Tayeb K, Monvoisin A, Mazzocco C, et al. Matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis. Am J Pathol. 2006;169(4):1390-1401. doi:10.2353/ajpath.2006.060005; Zuo X, Pan W, Feng T, Shi X, Dai J (2014) Matrix Metalloproteinase 3 Promotes Cellular Anti-Dengue Virus Response via Interaction with Transcription Factor NFkB in Cell Nucleus. PLoS ONE 9(1): e84748. https://doi.org/10.1371/journal.pone.0084748; Eguchi T, Kubota S, Kawata K, et al. Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene. Mol Cell Biol. 2008;28(7):2391-2413. doi:10.1128/MCB.01288-07
E.C. numberNA
Location of functional site(s)NA
Cellular location of functionnucleus
CommentsNA