| General Information |
| MoonProt ID | 451 |
| First appeared in release | 3.0 |
| Name(s) | Stromelysin-1, Matrix metalloproteinase-3, Transin-1
Gene: MMP3 |
| UniProt ID | P03957 (MMP3_RAT) |
| GO terms | GO:0001666 response to hypoxia
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006508 proteolysis
GO:0007565 female pregnancy
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0009612 response to mechanical stimulus
GO:0010727 negative regulation of hydrogen peroxide metabolic process
GO:0016787 hydrolase activity
GO:0030163 protein catabolic process
GO:0030198 extracellular matrix organization
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0030425 dendrite
GO:0030574 collagen catabolic process
GO:0031012 extracellular matrix
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0032991 protein-containing complex
GO:0034097 response to cytokine
GO:0034612 response to tumor necrosis factor |
| Organisms for which functions have been demonstrated | Rattus norvegicus (Rat, mammal) |
| Sequence length | 475 amino acids |
| FASTA sequence | >sp|P03957|MMP3_RAT Stromelysin-1 OS=Rattus norvegicus OX=10116 GN=Mmp3 PE=1 SV=1
MKGLPVLLWLCTAVCSSYPLHGSEEDAGMEVLQKYLENYYGLEKDVKQFTKKKDSSPVVKKIQEMQKFLGLKMTGKLDSNTMELMHKPRCGVPDVGGFSTFPGSPKWRKNHISYRIVNYTLDLPRESVDSAIERALKVWEEVTPLTFSRISEGEADIMISFAVEEHGDFIPFDGPGMVLAHAYAPGPGTNGDAHFDDDERWTDDVTGTNLFLVAAHELGHSLGLFHSANAEALMYPVYKSSTDLARFHLSQDDVDGIQSLYGPPTESPDVLVVPTKSNSLDPETLPMCSSALSFDAVSTLRGEVLFFKDRHFWRKSLRTPEPGFYLISSFWPSLPSNMDAAYEVTNRDTVFILKGNQIWAIRGHEELAGYPKSIHTLGLPETVQKIDAAISLKDQKKTYFFVEDKFWRFDEKKQSMDPEFPRKIAENFPGIGTKVDAVFEAFGFLYFFSGSSQLEFDPNAGKVTHILKSNSWFNC |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
moonID_451_uniID_P03957 is 475 residues long, with 0 residues (0.00%) predicted as disordered.The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments. |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Metalloprotease (degrades fibronectin, gelatin, proteoglycans, denatured type I collagen, laminin, and other extracellular matrix components) |
| References for function | Umenishi F, Yasumitsu H, Ashida Y, Yamauti J, Umeda M, Miyazaki K. Purification and properties of extracellular matrix-degrading metallo-proteinase overproduced by Rous sarcoma virus-transformed rat liver cell line, and its identification as transin. J Biochem. 1990;108(4):537-543. doi:10.1093/oxfordjournals.jbchem.a123238 |
| E.C. number | 3.4.24.17 |
| Location of functional site(s) | NA |
| Cellular location of function | cell surface |
| Comments | NA |
| Function 2 |
| Function description | transcription factor |
| References for function | NA |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | nucleus |
| Comments | NA |