| General Information |
| MoonProt ID | 452 |
| First appeared in release | 3.0 |
| Name(s) | Protein-glutamine gamma-glutamyltransferase 2, Tissue transglutaminase, Transglutaminase C,
Transglutaminase-2
Gene: Tgm2 |
| UniProt ID | P21980 (TGM2_HUMAN) |
| GO terms | GO:0031226 intrinsic component of plasma membrane
GO:0005739 mitochondrion
GO:0018149 peptide cross-linking
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0005515 protein binding
GO:0050729 positive regulation of inflammatory response
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0005525 GTP binding
GO:0001974 blood vessel remodeling
GO:0060662 salivary gland cavitation
GO:0060445 branching involved in salivary gland morphogenesis
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0042802 identical protein binding
GO:0019904 protein domain specific binding
GO:0005886 plasma membrane
GO:0005737 cytoplasm
GO:0045785 positive regulation of cell adhesion
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0062023 collagen-containing extracellular matrix
GO:0005829 cytosol
GO:0005783 endoplasmic reticulum
GO:0043277 apoptotic cell clearance
GO:0070062 extracellular exosome
GO:0005925 focal adhesion |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 687 amino acids |
| FASTA sequence | >sp|P21980|TGM2_HUMAN Protein-glutamine gamma-glutamyltransferase 2 OS=Homo sapiens OX=9606 GN=TGM2 PE=1 SV=2
MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFSVVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVGQSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEKSVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQKRKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVIIGPA |
| Structure Information |
| PDB ID | 3S3J_A |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
moonID_452_uniID_P21980 is 687 residues long, with 0 residues (0.00%) predicted as disordered.The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments. |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Transglutaminase (catalyze protein crosslinking via transamidation of glutamine residues to lysine residues in a Ca2+-dependent manner) |
| References for function | Lorand L, Graham RM. Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol. 2003;4:140–156. |
| E.C. number | 2.3.2.13 |
| Location of functional site(s) | NA |
| Cellular location of function | NA |
| Comments | NA |
| Function 2 |
| Function description | GTPase, GTP binding protein |
| References for function | Iismaa SE, Wu MJ, Nanda N, Church WB, Graham RM. GTP Binding and Signaling by Gh/Transglutaminase II Involves Distinct Residues in a Unique GTP-binding Pocket. J Biol Chem. 2000;275:18259–18265. |
| E.C. number | NA |
| Location of functional site(s) | unique GTP binding pocket and GTP hydrolysis activity, suggesting TG2 may be implicated in receptor signaling
|
| Cellular location of function | NA |
| Comments | NA |