Protein Information

General Information
MoonProt ID453
First appeared in release3.0
Name(s)Protein-glutamine gamma-glutamyltransferase 2, Tissue transglutaminase, Transglutaminase C, Transglutaminase-2 Gene: Tgm2
UniProt IDP21981 (TGM2_MOUSE)
GO termsGO:0005739 mitochondrion GO:0018149 peptide cross-linking GO:0003810 protein-glutamine gamma-glutamyltransferase activity GO:0046872 metal ion binding GO:0016740 transferase activity GO:0016746 transferase activity, transferring acyl groups GO:0042802 identical protein binding GO:0019904 protein domain specific binding GO:0008483 transaminase activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005525 GTP binding GO:0060662 salivary gland cavitation GO:0060445 branching involved in salivary gland morphogenesis GO:0051561 positive regulation of mitochondrial calcium ion concentration GO:0050729 positive regulation of inflammatory response GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine GO:0005737 cytoplasm GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0048661 positive regulation of smooth muscle cell proliferation GO:0043277 apoptotic cell clearance GO:0043065 positive regulation of apoptotic process GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration GO:0031226 intrinsic component of plasma membrane GO:0005886 plasma membrane GO:0005829 cytosol GO:0001974 blood vessel remodeling GO:0062023 collagen-containing extracellular matrix GO:0005783 endoplasmic reticulum GO:0005509 calcium ion binding GO:0031012 extracellular matrix GO:0045785 positive regulation of cell adhesion GO:0016020 membrane GO:0007186 G protein-coupled receptor signaling pathway
Organisms for which functions have been demonstratedMus musculus (Mouse, mammal)
Sequence length686 amino acids
FASTA sequence>sp|P21981|TGM2_MOUSE Protein-glutamine gamma-glutamyltransferase 2 OS=Mus musculus OX=10090 GN=Tgm2 PE=1 SV=4 MAEELLLERCDLEIQANGRDHHTADLCQEKLVLRRGQRFRLTLYFEGRGYEASVDSLTFGAVTGPDPSEEAGTKARFSLSDNVEEGSWSASVLDQQDNVLSLQLCTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLYNAWCPADDVYLDSEEERREYVLTQQGFIYQGSVKFIKSVPWNFGQFEDGILDTCLMLLDMNPKFLKNRSRDCSRRSSPIYVGRVVSAMVNCNDDQGVLLGRWDNNYGDGISPMAWIGSVDILRRWKEHGCQQVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGELESNKSEMIWNFHCWVESWMTRPDLQPGYEGWQAIDPTPQEKSEGTYCCGPVSVRAIKEGDLSTKYDAPFVFAEVNADVVDWIRQEDGSVLKSINRSLVVGQKISTKSVGRDDREDITHTYKYPEGSPEEREVFTKANHLNKLAEKEETGVAMRIRVGDSMSMGNDFDVFAHIGNDTSETRECRLLLCARTVSYNGVLGPECGTEDINLTLDPYSENSIPLRILYEKYSGCLTESNLIKVRGLLIEPAANSYLLAERDLYLENPEIKIRVLGEPKQNRKLVAEVSLKNPLSDPLYDCIFTVEGAGLTKEQKSVEVSDPVPAGDLVKARVDLFPTDIGLHKLVVNFQCDKLKSVKGYRNVIIGPA
Structure Information
PDB ID3S3J_A, 4PYG_A
Quaternary structureNA
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder RegionsUse FASTA sequence on the MFDp2 webserver. moonID_453_uniID_P21981 is 686 residues long, with 0 residues (0.00%) predicted as disordered.The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments.
Connections to Disease
OMIM ID
Function 1
Function descriptionTransglutaminase (catalyze protein crosslinking via transamidation of glutamine residues to lysine residues in a Ca2+-dependent manner)
References for functionLorand L, Graham RM. Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol. 2003;4:140–156.
E.C. number2.3.2.13
Location of functional site(s)NA
Cellular location of functionNA
CommentsNA
Function 2
Function descriptionGTPase, GTP binding protein
References for functionIismaa SE, Wu MJ, Nanda N, Church WB, Graham RM. GTP Binding and Signaling by Gh/Transglutaminase II Involves Distinct Residues in a Unique GTP-binding Pocket. J Biol Chem. 2000;275:18259–18265.
E.C. numberNA
Location of functional site(s) NA
Cellular location of functionNA
CommentsNA