General Information |
MoonProt ID | 453 |
First appeared in release | 3.0 |
Name(s) | Protein-glutamine gamma-glutamyltransferase 2, Tissue transglutaminase, Transglutaminase C,
Transglutaminase-2
Gene: Tgm2 |
UniProt ID | P21981 (TGM2_MOUSE) |
GO terms | GO:0005739 mitochondrion
GO:0018149 peptide cross-linking
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0046872 metal ion binding
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0042802 identical protein binding
GO:0019904 protein domain specific binding
GO:0008483 transaminase activity
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0005525 GTP binding
GO:0060662 salivary gland cavitation
GO:0060445 branching involved in salivary gland morphogenesis
GO:0051561 positive regulation of mitochondrial calcium ion concentration
GO:0050729 positive regulation of inflammatory response
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
GO:0005737 cytoplasm
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0043277 apoptotic cell clearance
GO:0043065 positive regulation of apoptotic process
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0031226 intrinsic component of plasma membrane
GO:0005886 plasma membrane
GO:0005829 cytosol
GO:0001974 blood vessel remodeling
GO:0062023 collagen-containing extracellular matrix GO:0005783 endoplasmic reticulum
GO:0005509 calcium ion binding
GO:0031012 extracellular matrix
GO:0045785 positive regulation of cell adhesion
GO:0016020 membrane
GO:0007186 G protein-coupled receptor signaling pathway |
Organisms for which functions have been demonstrated | Mus musculus (Mouse, mammal) |
Sequence length | 686 amino acids |
FASTA sequence | >sp|P21981|TGM2_MOUSE Protein-glutamine gamma-glutamyltransferase 2 OS=Mus musculus OX=10090 GN=Tgm2 PE=1 SV=4
MAEELLLERCDLEIQANGRDHHTADLCQEKLVLRRGQRFRLTLYFEGRGYEASVDSLTFGAVTGPDPSEEAGTKARFSLSDNVEEGSWSASVLDQQDNVLSLQLCTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLYNAWCPADDVYLDSEEERREYVLTQQGFIYQGSVKFIKSVPWNFGQFEDGILDTCLMLLDMNPKFLKNRSRDCSRRSSPIYVGRVVSAMVNCNDDQGVLLGRWDNNYGDGISPMAWIGSVDILRRWKEHGCQQVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGELESNKSEMIWNFHCWVESWMTRPDLQPGYEGWQAIDPTPQEKSEGTYCCGPVSVRAIKEGDLSTKYDAPFVFAEVNADVVDWIRQEDGSVLKSINRSLVVGQKISTKSVGRDDREDITHTYKYPEGSPEEREVFTKANHLNKLAEKEETGVAMRIRVGDSMSMGNDFDVFAHIGNDTSETRECRLLLCARTVSYNGVLGPECGTEDINLTLDPYSENSIPLRILYEKYSGCLTESNLIKVRGLLIEPAANSYLLAERDLYLENPEIKIRVLGEPKQNRKLVAEVSLKNPLSDPLYDCIFTVEGAGLTKEQKSVEVSDPVPAGDLVKARVDLFPTDIGLHKLVVNFQCDKLKSVKGYRNVIIGPA |
Structure Information |
PDB ID | 3S3J_A, 4PYG_A |
Quaternary structure | NA |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
moonID_453_uniID_P21981 is 686 residues long, with 0 residues (0.00%) predicted as disordered.The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments. |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Transglutaminase (catalyze protein crosslinking via transamidation of glutamine residues to lysine residues in a Ca2+-dependent manner) |
References for function | Lorand L, Graham RM. Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol. 2003;4:140–156. |
E.C. number | 2.3.2.13 |
Location of functional site(s) | NA |
Cellular location of function | NA |
Comments | NA |
Function 2 |
Function description | GTPase, GTP binding protein |
References for function | Iismaa SE, Wu MJ, Nanda N, Church WB, Graham RM. GTP Binding and Signaling by Gh/Transglutaminase II Involves Distinct Residues in a Unique GTP-binding Pocket. J Biol Chem. 2000;275:18259–18265. |
E.C. number | NA |
Location of functional site(s) |
NA |
Cellular location of function | NA |
Comments | NA |