| General Information |
| MoonProt ID | 456 |
| First appeared in release | 3.0 |
| Name(s) | Phosphoketolase |
| UniProt ID | D6D942 |
| GO terms | GO:0016829 lyase activity
GO:0047905 fructose-6-phosphate phosphoketolase activity |
| Organisms for which functions have been demonstrated | Bifidobacterium longum (strain NCC 2705) (Gram positive bacterium) |
| Sequence length | 825 amino acids |
| FASTA sequence | >tr|D6D942|D6D942_BIFLN Phosphoketolase OS=Bifidobacterium longum subsp. longum F8 OX=722911 GN=BIL_11880 PE=3 SV=1
MTSPVIGTPWKKLNAPVSEEALEGVDKYWRVANYLSIGQIYLRSNPLMKEPFTREDVKHRLVGHWGTTPGLNFLIGHINRFIADHGQNTVIIMGPGHGGPAGTSQSYLDGTYTETFPKITKDEAGLQKFFRQFSYPGGIPSHFAPETPGSIHEGGELGYALSHAYGAIMDNPSLFVPAIVGDGEAETGPLATGWQSNKLVNPRTDGIVLPILHLNGYKIANPTILSRISDEELHEFFHGMGYEPYEFVAGFDDEDHMSIHRRFAELWETIWDEICDIKATAQTDNVHRPFYPMLIFRTPKGWTCPKYIDGKKTEGSWRSHQVPLASARDTEAHFEVLKNWLESYKPEELFDANGAVKDDVLAFMPKGELRIGANPNANGGVIRNDLKLPNLEDYEVKEVAEYGHGWGQLEATRTLGAYTRDIIKNNPRDFRIFGPDETASNRLQASYEVTNKQWDAGYISDEVDEHMHVSGQVVEQLSEHQMEGFLEAYLLTGRHGIWSSYESFVHVIDSMLNQHAKWLEATVREIPWRKPIASMNLLVSSHVWRQDHNGFSHQDPGVTSVLLNKCFHNDHVIGIYFATDANMLLAIAEKCYKSTNKINAIIAGKQPAATWLTLDEARAELEKGAAAWDWASTAKNNDEAEVVLAAAGDVPTQEIMAASDKLKELGVKFKVVNVADLLSLQSAKENDEALTDEEFADIFTADKPVLFAYHSYAHDVRGLIYDRPNHDNFNVHGYEEEGSTTTPYDMVRVNRIDRYELTAEALRMIDADKYADKIDELEKFRDEAFQFAVDNGYDHPDYTDWVYSGVNTDKKGAVTATAATAGDNE |
| Structure Information |
| PDB ID | 3AI7 |
| Quaternary structure | dimer |
| SCOP | class 1000002 Alpha and beta proteins (a/b);
fold 2000314 TK C-terminal domain-like;
superfamily 3000424 TK C-terminal domain-like;
family 4004115 XFP C-terminal domain-like;
domain 8044752 3AI7 G:625-814 Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase Species Bifidobacterium longum. |
| CATH | 24 matching domains.
Domain: 3ai7A01 PDB code 3ai7, chain A, domain 01 Superfamily: 3.40.50.970
Domain: 3ai7A02 PDB code 3ai7, chain A, domain 02 Superfamily: 3.40.50.970
Domain: 3ai7A03 PDB code 3ai7, chain A, domain 03 Superfamily: 3.40.50.920
Domain: 3ai7B01 PDB code 3ai7, chain B, domain 01 Superfamily: 3.40.50.970
Domain: 3ai7B02 PDB code 3ai7, chain B, domain 02 Superfamily: 3.40.50.970
Domain: 3ai7B03 PDB code 3ai7, chain B, domain 03 Superfamily: 3.40.50.920
Domain: 3ai7C01 PDB code 3ai7, chain C, domain 01 Superfamily: 3.40.50.970
Domain: 3ai7C02 PDB code 3ai7, chain C, domain 02 Superfamily: 3.40.50.970
Domain: 3ai7C03 PDB code 3ai7, chain C, domain 03 Superfamily: 3.40.50.920
Domain: 3ai7D01 PDB code 3ai7, chain D, domain 01 Superfamily: 3.40.50.970
Domain: 3ai7D02 PDB code 3ai7, chain D, domain 02 Superfamily: 3.40.50.970
Domain: 3ai7D03 PDB code 3ai7, chain D, domain 03 Superfamily: 3.40.50.920
Domain: 3ai7E01 PDB code 3ai7, chain E, domain 01 Superfamily: 3.40.50.970
Domain: 3ai7E02 PDB code 3ai7, chain E, domain 02 Superfamily: 3.40.50.970
Domain: 3ai7E03 PDB code 3ai7, chain E, domain 03 Superfamily: 3.40.50.920
Domain: 3ai7F01 PDB code 3ai7, chain F, domain 01 Superfamily: 3.40.50.970
Domain: 3ai7F02 PDB code 3ai7, chain F, domain 02 Superfamily: 3.40.50.970
Domain: 3ai7F03 PDB code 3ai7, chain F, domain 03 Superfamily: 3.40.50.920
Domain: 3ai7G01 PDB code 3ai7, chain G, domain 01 Superfamily: 3.40.50.970
Domain: 3ai7G02 PDB code 3ai7, chain G, domain 02 Superfamily: 3.40.50.970
Domain: 3ai7G03 PDB code 3ai7, chain G, domain 03 Superfamily: 3.40.50.920
Domain: 3ai7H01 PDB code 3ai7, chain H, domain 01 Superfamily: 3.40.50.970
Domain: 3ai7H02 PDB code 3ai7, chain H, domain 02 Superfamily: 3.40.50.970
Domain: 3ai7H03 PDB code 3ai7, chain H, domain 03 Superfamily: 3.40.50.920 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | Use FASTA sequence on MFDp2 webserver.
trD6D942D6D942_BIFLN_Pho is 825 residues long, with 37 residues (4.48 %) predicted as disordered. The protein has 2 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments.
Segment 1 - Short (< 30 residues) disordered segment
Segment is located between positions 1 and 17 in the sequence.
The segment is 17 residues long (2.06 % of the total sequence length).
Segment 2 - Short (< 30 residues) disordered segment
Segment is located between positions 806 and 825 in the sequence.
The segment is 20 residues long (2.42 % of the total sequence length). |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Phosphoketolase |
| References for function | Grill JP, Crociani J, Ballongue J. Characterization of fructose 6 phosphate phosphoketolases purified from Bifidobacterium species. Curr Microbiol. 1995 Jul;31(1):49-54. doi: 10.1007/BF00294634. PMID: 7767228. |
| E.C. number | 4.1.2.22 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | Binds mucin |
| References for function | Nishiyama K, Takaki T, Sugiyama M, Fukuda I, Aiso M, Mukai T, Odamaki T, Xiao JZ, Osawa R, Okada N. Extracellular vesicles produced by Bifidobacterium longum export mucin-binding proteins. Appl Environ Microbiol. 2020 Jul 31:AEM.01464-20. doi: 10.1128/AEM.01464-20. Epub ahead of print. PMID: 32737132. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | extracellular |
| Comments | |