Protein Information

General Information
MoonProt ID457
First appeared in release3.0
Name(s)GroEL Recommended name: 60 kDa chaperonin Alternative name(s): GroEL protein Protein Cpn60
UniProt IDQ8G879
GO termsGO:0000166 nucleotide binding GO:0005524 ATP binding GO:0005737 cytoplasm GO:0051082 unfolded protein binding GO:0042026 protein refolding
Organisms for which functions have been demonstratedBifidobacterium longum (strain NCC 2705) (Gram positive bacterium)
Sequence length541 amino acids
FASTA sequence>sp|Q8G879|CH60_BIFLO 60 kDa chaperonin OS=Bifidobacterium longum (strain NCC 2705) OX=206672 GN=groL PE=3 SV=1 MAKIISYDEEARQGMLEGLDKLANTVKVTLGPKGRNVVLDKTYGAPTITNDGVSIAKEIDLEDPYERIGAELVKEVAKKTDDVAGDGTTTATVLAQSLVHEGLKNVVAGSNPIALRRGIEKATEVIVKELVAAAKDVETKDQIAATATISAADPEVGEKIAEALDKVGQDGVVTVEDNNRFGLDLDFTEGMRFDKGYIAPYFVTNADDQTAVLEDPYILLTSGKVSSQQDIVHVAELVMKTGKPLLIIAEDVDGEALPTLILNNIRGTFKSCAVKAPGFGDRRKAMLQDMAILTGAQVVSDELGLKLESVDTSVLGHAKKVIVSKDETTIVQGAGSKEDIDARVAQIRAEIENTDSDYDREKLQERLAKLAGGVAVIKVGAATEVEAKERKHRIEDAVRNAKAAIEEGLLPGGGVALVQAAAKAEKTEAVTSLTGEEATGAAIVFRAIEAPIKQIAENAGVSGDVVINTVRSLPDGEGFNAATDTYEDLLAAGVTDPVKVTRSALQNAASIAGLFLTTEAVVANKPEPKSAAPAAGADMGY
Structure Information
PDB IDNA
Quaternary structureNA
SCOP
CATH
TM Helix Predictionno TM helices # sp|Q8G879|CH60_BIFLO Number of predicted TMHs: 0 # sp|Q8G879|CH60_BIFLO Exp number of AAs in TMHs: 0.00635 # sp|Q8G879|CH60_BIFLO Exp number, first 60 AAs: 0 # sp|Q8G879|CH60_BIFLO Total prob of N-in: 0.00206 sp|Q8G879|CH60_BIFLO TMHMM2.0 outside 1 541
DisProt AnnotationNot in DisProt
Predicted Disorder RegionsUse FASTA sequence on MFDp2 webserver. spQ8G879CH60_BIFLO_60_kD is 541 residues long, with 17 residues (3.14 %) predicted as disordered. The protein has 1 short (< 30 residues) disorder segment and 0 long (>= 30 residues) disorder segments. Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 525 and 541 in the sequence. The segment is 17 residues long (3.14 % of the total sequence length).
Connections to Disease
OMIM ID
Function 1
Function descriptionchaperone
References for functionVentura M, Canchaya C, Zink R, Fitzgerald GF, van Sinderen D. Characterization of the groEL and groES loci in Bifidobacterium breve UCC 2003: genetic, transcriptional, and phylogenetic analyses. Appl Environ Microbiol. 2004 Oct;70(10):6197-209. doi: 10.1128/AEM.70.10.6197-6209.2004. PMID: 15466567; PMCID: PMC522111.
E.C. number
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionBinds mucin
References for functionNishiyama K, Takaki T, Sugiyama M, Fukuda I, Aiso M, Mukai T, Odamaki T, Xiao JZ, Osawa R, Okada N. Extracellular vesicles produced by Bifidobacterium longum export mucin-binding proteins. Appl Environ Microbiol. 2020 Jul 31:AEM.01464-20. doi: 10.1128/AEM.01464-20. Epub ahead of print. PMID: 32737132.
E.C. number
Location of functional site(s)
Cellular location of functionextracellular
Comments