General Information |
MoonProt ID | 457 |
First appeared in release | 3.0 |
Name(s) | GroEL
Recommended name:
60 kDa chaperonin
Alternative name(s):
GroEL protein
Protein Cpn60 |
UniProt ID | Q8G879 |
GO terms | GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0051082 unfolded protein binding
GO:0042026 protein refolding |
Organisms for which functions have been demonstrated | Bifidobacterium longum (strain NCC 2705) (Gram positive bacterium) |
Sequence length | 541 amino acids |
FASTA sequence | >sp|Q8G879|CH60_BIFLO 60 kDa chaperonin OS=Bifidobacterium longum (strain NCC 2705) OX=206672 GN=groL PE=3 SV=1
MAKIISYDEEARQGMLEGLDKLANTVKVTLGPKGRNVVLDKTYGAPTITNDGVSIAKEIDLEDPYERIGAELVKEVAKKTDDVAGDGTTTATVLAQSLVHEGLKNVVAGSNPIALRRGIEKATEVIVKELVAAAKDVETKDQIAATATISAADPEVGEKIAEALDKVGQDGVVTVEDNNRFGLDLDFTEGMRFDKGYIAPYFVTNADDQTAVLEDPYILLTSGKVSSQQDIVHVAELVMKTGKPLLIIAEDVDGEALPTLILNNIRGTFKSCAVKAPGFGDRRKAMLQDMAILTGAQVVSDELGLKLESVDTSVLGHAKKVIVSKDETTIVQGAGSKEDIDARVAQIRAEIENTDSDYDREKLQERLAKLAGGVAVIKVGAATEVEAKERKHRIEDAVRNAKAAIEEGLLPGGGVALVQAAAKAEKTEAVTSLTGEEATGAAIVFRAIEAPIKQIAENAGVSGDVVINTVRSLPDGEGFNAATDTYEDLLAAGVTDPVKVTRSALQNAASIAGLFLTTEAVVANKPEPKSAAPAAGADMGY |
Structure Information |
PDB ID | NA |
Quaternary structure | NA |
SCOP | |
CATH | |
TM Helix Prediction | no TM helices
# sp|Q8G879|CH60_BIFLO Number of predicted TMHs: 0
# sp|Q8G879|CH60_BIFLO Exp number of AAs in TMHs: 0.00635
# sp|Q8G879|CH60_BIFLO Exp number, first 60 AAs: 0
# sp|Q8G879|CH60_BIFLO Total prob of N-in: 0.00206
sp|Q8G879|CH60_BIFLO TMHMM2.0 outside 1 541 |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | Use FASTA sequence on MFDp2 webserver.
spQ8G879CH60_BIFLO_60_kD is 541 residues long, with 17 residues (3.14 %) predicted as disordered. The protein has 1 short (< 30 residues) disorder segment and 0 long (>= 30 residues) disorder segments.
Segment 1 - Short (< 30 residues) disordered segment
Segment is located between positions 525 and 541 in the sequence.
The segment is 17 residues long (3.14 % of the total sequence length). |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | chaperone |
References for function | Ventura M, Canchaya C, Zink R, Fitzgerald GF, van Sinderen D. Characterization of the groEL and groES loci in Bifidobacterium breve UCC 2003: genetic, transcriptional, and phylogenetic analyses. Appl Environ Microbiol. 2004 Oct;70(10):6197-209. doi: 10.1128/AEM.70.10.6197-6209.2004. PMID: 15466567; PMCID: PMC522111. |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | Binds mucin |
References for function | Nishiyama K, Takaki T, Sugiyama M, Fukuda I, Aiso M, Mukai T, Odamaki T, Xiao JZ, Osawa R, Okada N. Extracellular vesicles produced by Bifidobacterium longum export mucin-binding proteins. Appl Environ Microbiol. 2020 Jul 31:AEM.01464-20. doi: 10.1128/AEM.01464-20. Epub ahead of print. PMID: 32737132. |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | extracellular |
Comments | |