| General Information |
| MoonProt ID | 457 |
| First appeared in release | 3.0 |
| Name(s) | GroEL
Recommended name:
60 kDa chaperonin
Alternative name(s):
GroEL protein
Protein Cpn60 |
| UniProt ID | Q8G879 |
| GO terms | GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0051082 unfolded protein binding
GO:0042026 protein refolding |
| Organisms for which functions have been demonstrated | Bifidobacterium longum (strain NCC 2705) (Gram positive bacterium) |
| Sequence length | 541 amino acids |
| FASTA sequence | >sp|Q8G879|CH60_BIFLO 60 kDa chaperonin OS=Bifidobacterium longum (strain NCC 2705) OX=206672 GN=groL PE=3 SV=1
MAKIISYDEEARQGMLEGLDKLANTVKVTLGPKGRNVVLDKTYGAPTITNDGVSIAKEIDLEDPYERIGAELVKEVAKKTDDVAGDGTTTATVLAQSLVHEGLKNVVAGSNPIALRRGIEKATEVIVKELVAAAKDVETKDQIAATATISAADPEVGEKIAEALDKVGQDGVVTVEDNNRFGLDLDFTEGMRFDKGYIAPYFVTNADDQTAVLEDPYILLTSGKVSSQQDIVHVAELVMKTGKPLLIIAEDVDGEALPTLILNNIRGTFKSCAVKAPGFGDRRKAMLQDMAILTGAQVVSDELGLKLESVDTSVLGHAKKVIVSKDETTIVQGAGSKEDIDARVAQIRAEIENTDSDYDREKLQERLAKLAGGVAVIKVGAATEVEAKERKHRIEDAVRNAKAAIEEGLLPGGGVALVQAAAKAEKTEAVTSLTGEEATGAAIVFRAIEAPIKQIAENAGVSGDVVINTVRSLPDGEGFNAATDTYEDLLAAGVTDPVKVTRSALQNAASIAGLFLTTEAVVANKPEPKSAAPAAGADMGY |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices
# sp|Q8G879|CH60_BIFLO Number of predicted TMHs: 0
# sp|Q8G879|CH60_BIFLO Exp number of AAs in TMHs: 0.00635
# sp|Q8G879|CH60_BIFLO Exp number, first 60 AAs: 0
# sp|Q8G879|CH60_BIFLO Total prob of N-in: 0.00206
sp|Q8G879|CH60_BIFLO TMHMM2.0 outside 1 541 |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | Predicted disorder at N terminus (aa 1-6), and C terminus (aa 533-541) |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | chaperone |
| References for function | Ventura M, Canchaya C, Zink R, Fitzgerald GF, van Sinderen D. Characterization of the groEL and groES loci in Bifidobacterium breve UCC 2003: genetic, transcriptional, and phylogenetic analyses. Appl Environ Microbiol. 2004 Oct;70(10):6197-209. doi: 10.1128/AEM.70.10.6197-6209.2004. PMID: 15466567; PMCID: PMC522111. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | Binds mucin |
| References for function | Nishiyama K, Takaki T, Sugiyama M, Fukuda I, Aiso M, Mukai T, Odamaki T, Xiao JZ, Osawa R, Okada N. Extracellular vesicles produced by Bifidobacterium longum export mucin-binding proteins. Appl Environ Microbiol. 2020 Jul 31:AEM.01464-20. doi: 10.1128/AEM.01464-20. Epub ahead of print. PMID: 32737132. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | extracellular |
| Comments | |