| General Information |
| MoonProt ID | 459 |
| First appeared in release | 3.0 |
| Name(s) | phosphoglycerate kinase
gene: pgk |
| UniProt ID | Q8G6D6 (PGK_BIFLO) |
| GO terms | GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0005737 cytoplasm
GO:0000166 nucleotide binding
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0005524 ATP binding
GO:0004618 phosphoglycerate kinase activity
|
| Organisms for which functions have been demonstrated | Bifidobacterium longum (strain NCC 2705) (Gram positive bacterium) |
| Sequence length | 401 amino acids |
| FASTA sequence | >sp|Q8G6D6|PGK_BIFLO Phosphoglycerate kinase OS=Bifidobacterium longum (strain NCC 2705) OX=206672 GN=pgk PE=3 SV=2
MKTLKDLGDLKGKRVLVRADFNVPLDGTTITDDGRIKAALPTIKTLREEGAKVILMAHLGRPKGKVVPELSLAPVAARLGELLGANVPLAKDTYGEDAQAKVAAMNDGDVVLLENVRFNPEETSKDADERAAYAKKIAALGEAFVSDGFGVVHRAQGSNYDVAADLPAAAGLLVEKEVKALSKATENPERPFTVVLGGSKVSDKLGVIENLLDKANRLVIGGGMVFTFLKAKGYEVGTSLLEEDQLEKVKGYIETAEKNGVELVLPTDVVVNAGFPAGDTPVAPEVVAADAIPADKMGLDIGPESQKLFHDKIVDSKTVVWNGPMGVFEVPEFAAGTKAVAQGLVDATAVGAFTIVGGGDSASAVRNLGFPEDGFSHISTGGGASLEFLEGKELPGLKVLE |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices
# sp|Q8G6D6|PGK_BIFLO Number of predicted TMHs: 0
# sp|Q8G6D6|PGK_BIFLO Exp number of AAs in TMHs: 0.02394
# sp|Q8G6D6|PGK_BIFLO Exp number, first 60 AAs: 0
# sp|Q8G6D6|PGK_BIFLO Total prob of N-in: 0.00431
sp|Q8G6D6|PGK_BIFLO TMHMM2.0 outside 1 401 |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | Use FASTA sequence on MFDp2 webserver.
spQ8G6D6PGK_BIFLO_Phosph is 401 residues long, with 0 residues (0.00 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments. |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Phosphoglycerate kinase.
This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate. |
| References for function | Gorska S, Dylus E, Rudawska A, Brzozowska E, Srutkova D, Schwarzer M, Razim A, Kozakova H, Gamian A. Immunoreactive proteins of Bifidobacterium longum ssp. longum CCM 7952 and Bifidobacterium longum ssp. longum CCDM 372 Identified by gnotobiotic mono-colonized mice sera, immune rabbit sera and non-immune human sera. Frontiers in microbiology. 2016 Sep 29;7:1537. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds mucin |
| References for function | Nishiyama K, Takaki T, Sugiyama M, Fukuda I, Aiso M, Mukai T, Odamaki T, Xiao JZ, Osawa R, Okada N. Extracellular vesicles produced by Bifidobacterium longum export mucin-binding proteins. Appl Environ Microbiol. 2020 Jul 31:AEM.01464-20. doi: 10.1128/AEM.01464-20. Epub ahead of print. PMID: 32737132. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | extracellular |
| Comments | |