General Information |
MoonProt ID | 464 |
First appeared in release | 3.0 |
Name(s) | IFT88
Recommended name: Intraflagellar transport protein 88 homolog
Alternative name(s):
Recessive polycystic kidney disease protein Tg737
Tetratricopeptide repeat protein 10
Short name:
TPR repeat protein 10
TgN(Imorpk)737Rpw |
UniProt ID | Q61371 (IFT88_MOUSE) |
GO terms | GO:0031122 ciliary basal body
GO:0021537 cilium assembly
GO:0021513 centriole
GO:0009953 sperm flagellum
GO:0009953 cytoplasm
GO:0009952 intraciliary transport particle B
GO:0009887 photoreceptor connecting cilium
GO:0008544 cilium
GO:0007288 centriole
GO:0007219 regulation of autophagosome assembly
GO:0005813 regulation of cilium assembly
GO:0005802 cilium assembly
GO:0002081 cell projection organization
GO:0001886 cell projection
GO:0001822 cytoskeleton
GO:0001822 motile cilium
GO:0005815 microtubule organizing center
GO:0005515 protein binding |
Organisms for which functions have been demonstrated | Mus musculus (Mouse, mammal) |
Sequence length | 824 amino acids |
FASTA sequence | >sp|Q61371|IFT88_MOUSE Intraflagellar transport protein 88 homolog OS=Mus musculus OX=10090 GN=Ift88 PE=1 SV=2
MENVHLAPETDEDDLYSGFNDYNPAYDTEELENDTGFQQAVRTSHGRRPPVTAKIPSTAVSRPIATGYGSKTSLTSSMGRPMTGTIQDGVARPMTAVRAAGFSKAALRGSAFDPLGQSRGPAPPLEAKNEDSPEEKIRQLEKKVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTSPENINLDLTYSVLFNLASQYSANEMYAEALNTYQVIVKNKMFSNAGRLKVNMGNIYLKQRNYSKAIKFYRMALDQIPSVHKEMRIKIMQNIGITFIKTGQYSDAINSFEHIMSMAPSLKAGFNLILSCFAIGDREKMKKAFQKLIAVPLEIDEDDKYISPSDDPHTNLLIEAIKNDHLRQMERERKAMAEKYIMTAAKLIAPVIEASFAVGYNWCVEVVKASQYVELANDLEINKAITYLRQKDFNQAVDTLKMFEKKDSRVKSAAATNLSFLYYLENEFAQASSYADLAVNSDRYNPSALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYKKLNRLDEALDSFLKLHAILRNSAQVLCQIANIYELMEDPNQAIEWLMQLISVVPTDSQALSKLGELYDSEGDKSQAFQYYYESYRYFPSNIEVIEWLGAYYIDTQFCEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKEIHRKFPENVECLRFLVRLCTDIGLKEVQEYATKLKRLEKMKEMREQRIKSGRDSSGGSRSKREGSAGSDSGQNNSASSKSERLSAKLRALPGTDEPYESSGNKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE |
Structure Information |
PDB ID | NA |
Quaternary structure | NA |
SCOP | |
CATH | |
TM Helix Prediction | no TM helices
# sp|Q61371|IFT88_MOUSE Number of predicted TMHs: 0
# sp|Q61371|IFT88_MOUSE Exp number of AAs in TMHs: 0.06167
# sp|Q61371|IFT88_MOUSE Exp number, first 60 AAs: 0
# sp|Q61371|IFT88_MOUSE Total prob of N-in: 0.00029
sp|Q61371|IFT88_MOUSE TMHMM2.0 outside 1 824 |
DisProt Annotation | |
Predicted Disorder Regions | Use FASTA sequence on MFDp2 webserver.
spQ61371IFT88_MOUSE_Intr is 824 residues long, with 260 residues (31.55 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 2 long (>= 30 residues) disorder segments.
Segment 1 - Long (>= 30 residues) disordered segment
Segment is located between positions 1 and 149 in the sequence.
The segment is 149 residues long (18.08 % of the total sequence length).
Segment 2 - Long (>= 30 residues) disordered segment
Segment is located between positions 714 and 824 in the sequence.
The segment is 111 residues long (13.47 % of the total sequence length). |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Mouse ciliary protein.
Involved in primary cilium biogenesis. |
References for function | Pazour GJ, Dickert BL, Vucica Y, Seeley ES, Rosenbaum JL, Witman GB, Cole DG. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol. 2000 Oct 30;151(3):709-18. doi: 10.1083/jcb.151.3.709. PMID: 11062270; PMCID: PMC2185580. |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | cilium |
Comments | |
Function 2 |
Function description | regulates NFkappaB signaling |
References for function | McFie M, Koneva L, Collins I, Coveney CR, Clube AM, Chanalaris A, Vincent TL, Bezbradica JS, Sansom SN, Wann AK. Ciliary proteins specify the cell inflammatory response by tuning NFkB signaling, independently of primary cilia. Journal of Cell Science. 2020 Jan 1. PMID: 32503942 |
E.C. number | |
Location of functional site(s) | cytoplasm |
Cellular location of function | |
Comments | |