Protein Information

General Information
MoonProt ID464
First appeared in release3.0
Name(s)IFT88 Recommended name: Intraflagellar transport protein 88 homolog Alternative name(s): Recessive polycystic kidney disease protein Tg737 Tetratricopeptide repeat protein 10 Short name: TPR repeat protein 10 TgN(Imorpk)737Rpw
UniProt IDQ61371 (IFT88_MOUSE)
GO termsGO:0031122 ciliary basal body GO:0021537 cilium assembly GO:0021513 centriole GO:0009953 sperm flagellum GO:0009953 cytoplasm GO:0009952 intraciliary transport particle B GO:0009887 photoreceptor connecting cilium GO:0008544 cilium GO:0007288 centriole GO:0007219 regulation of autophagosome assembly GO:0005813 regulation of cilium assembly GO:0005802 cilium assembly GO:0002081 cell projection organization GO:0001886 cell projection GO:0001822 cytoskeleton GO:0001822 motile cilium GO:0005815 microtubule organizing center GO:0005515 protein binding
Organisms for which functions have been demonstratedMus musculus (Mouse, mammal)
Sequence length824 amino acids
FASTA sequence>sp|Q61371|IFT88_MOUSE Intraflagellar transport protein 88 homolog OS=Mus musculus OX=10090 GN=Ift88 PE=1 SV=2 MENVHLAPETDEDDLYSGFNDYNPAYDTEELENDTGFQQAVRTSHGRRPPVTAKIPSTAVSRPIATGYGSKTSLTSSMGRPMTGTIQDGVARPMTAVRAAGFSKAALRGSAFDPLGQSRGPAPPLEAKNEDSPEEKIRQLEKKVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTSPENINLDLTYSVLFNLASQYSANEMYAEALNTYQVIVKNKMFSNAGRLKVNMGNIYLKQRNYSKAIKFYRMALDQIPSVHKEMRIKIMQNIGITFIKTGQYSDAINSFEHIMSMAPSLKAGFNLILSCFAIGDREKMKKAFQKLIAVPLEIDEDDKYISPSDDPHTNLLIEAIKNDHLRQMERERKAMAEKYIMTAAKLIAPVIEASFAVGYNWCVEVVKASQYVELANDLEINKAITYLRQKDFNQAVDTLKMFEKKDSRVKSAAATNLSFLYYLENEFAQASSYADLAVNSDRYNPSALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYKKLNRLDEALDSFLKLHAILRNSAQVLCQIANIYELMEDPNQAIEWLMQLISVVPTDSQALSKLGELYDSEGDKSQAFQYYYESYRYFPSNIEVIEWLGAYYIDTQFCEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKEIHRKFPENVECLRFLVRLCTDIGLKEVQEYATKLKRLEKMKEMREQRIKSGRDSSGGSRSKREGSAGSDSGQNNSASSKSERLSAKLRALPGTDEPYESSGNKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE
Structure Information
PDB IDNA
Quaternary structureNA
SCOP
CATH
TM Helix Predictionno TM helices # sp|Q61371|IFT88_MOUSE Number of predicted TMHs: 0 # sp|Q61371|IFT88_MOUSE Exp number of AAs in TMHs: 0.06167 # sp|Q61371|IFT88_MOUSE Exp number, first 60 AAs: 0 # sp|Q61371|IFT88_MOUSE Total prob of N-in: 0.00029 sp|Q61371|IFT88_MOUSE TMHMM2.0 outside 1 824
DisProt Annotation
Predicted Disorder RegionsUse FASTA sequence on MFDp2 webserver. spQ61371IFT88_MOUSE_Intr is 824 residues long, with 260 residues (31.55 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 2 long (>= 30 residues) disorder segments. Segment 1 - Long (>= 30 residues) disordered segment Segment is located between positions 1 and 149 in the sequence. The segment is 149 residues long (18.08 % of the total sequence length). Segment 2 - Long (>= 30 residues) disordered segment Segment is located between positions 714 and 824 in the sequence. The segment is 111 residues long (13.47 % of the total sequence length).
Connections to Disease
OMIM ID
Function 1
Function descriptionMouse ciliary protein. Involved in primary cilium biogenesis.
References for functionPazour GJ, Dickert BL, Vucica Y, Seeley ES, Rosenbaum JL, Witman GB, Cole DG. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol. 2000 Oct 30;151(3):709-18. doi: 10.1083/jcb.151.3.709. PMID: 11062270; PMCID: PMC2185580.
E.C. number
Location of functional site(s)
Cellular location of functioncilium
Comments
Function 2
Function descriptionregulates NFkappaB signaling
References for functionMcFie M, Koneva L, Collins I, Coveney CR, Clube AM, Chanalaris A, Vincent TL, Bezbradica JS, Sansom SN, Wann AK. Ciliary proteins specify the cell inflammatory response by tuning NFkB signaling, independently of primary cilia. Journal of Cell Science. 2020 Jan 1. PMID: 32503942
E.C. number
Location of functional site(s)cytoplasm
Cellular location of function
Comments