General Information |
MoonProt ID | 466 |
First appeared in release | 3.0 |
Name(s) | TTBK2
Tau-tubulin kinase 2.
Recommended name:
Tau-tubulin kinase 2 (EC:2.7.11.1)
Alternative name(s):
Protein bartleby |
UniProt ID | Q3UVR3 (TTBK2_MOUSE) |
GO terms | GO:0021549 ciliary basal body
GO:0021681 ciliary transition zone
GO:0021935 centriole
GO:0060271 cilium assembly
GO:0036064 peptidyl-serine phosphorylation
GO:0035869 smoothened signaling pathway
GO:0018105 nucleus
GO:0005737 protein serine/threonine kinase activity
GO:0005634 cell projection
GO:0004674 transferase activity
GO:0036064 kinase activity
GO:0035869 cell projection organization
GO:0005814 cilium
GO:0060271 cytoplasm
GO:0018105 nucleotide binding
GO:0004674 ATP binding
GO:0004672 cytoskeleton
GO:0005524 phosphorylation
GO:0006468 cytosol |
Organisms for which functions have been demonstrated | Mus musculus (Mouse, mammal) |
Sequence length | 1243 amino acids |
FASTA sequence | >sp|Q3UVR3|TTBK2_MOUSE Tau-tubulin kinase 2 OS=Mus musculus OX=10090 GN=Ttbk2 PE=1 SV=1
MSGGGEQPDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGKQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCFMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSTFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKSGTDGSLTTTTTSATPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIPVGVSPDKLPGSLGHPRPQEKDVWEEMDINKNKIKLGICKAATEEENSHGQVNGILNAPSLGSPIRVRSEITQPDRDVPLVRKLRSIHSFELEKRLTLEPKPDTDKFLETCMEKMQKDSSAGKEPVPPALPHKPCVPVVTHTDHIWHYDDEYLPDASKPASANTPEQADGGGSNGFIAVNLSSCKQEVDSKEWVIVDKEQDLQDFRTNEVLGHKTTGSPSDEEPEVLQVLEGSPQDEKIQVGPWTDNHHLKKESSGVVLALSAECPATAASELYTDRLDLQAGAASQFITVTPTSPMEAQAEGPLTAITIPRPSVASTQSTSGSFHYGPQPEKKDLQPLEPTVELYSPRENFSGLVVTEGELASGGSRVDLGLQIDHTGHDMLPNMRDGDTSQDLGPKDPPDHNRLAVKEFEHLPGETEERSLLLGSENEDERLSKGQHCIEVSSPGELVTAERAQLAATEPLHVSETQNCSVLPNQDKTHEIMKLLAVGTSEISPQAIDPHAEGQIGQMAAMQKNKLFKDDGIQSESLPRQQGDLSAFLHQEGKREKVVPRNGELYHCVSENEHGPPTRKDMLRSSFVTRHSRIPVLAQEIDSTFESSSAISAKEKLLQKKAYQPEIVKLLVEKRQFKSFLGDLSSASDKLIEEKLAAVPVPFSEEEVFAPFSRLAADSHLSRSVEDSFLSPIISQARKSKIPRPVSWVSTDQINGSASPQFLPRPPPGKPPVRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKSRSTTQCKSPGSPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGPKGSGSLHHHSTSSKTPPGKSKPASKLSR |
Structure Information |
PDB ID | NA |
Quaternary structure | NA |
SCOP | |
CATH | |
TM Helix Prediction | no TM helices
# sp|Q3UVR3|TTBK2_MOUSE Number of predicted TMHs: 0
# sp|Q3UVR3|TTBK2_MOUSE Exp number of AAs in TMHs: 0.0692
# sp|Q3UVR3|TTBK2_MOUSE Exp number, first 60 AAs: 0.0002
# sp|Q3UVR3|TTBK2_MOUSE Total prob of N-in: 0.00383
sp|Q3UVR3|TTBK2_MOUSE TMHMM2.0 outside 1 1243 |
DisProt Annotation | |
Predicted Disorder Regions | Use FASTA sequence on MFDp2 webserver.
spQ3UVR3TTBK2_MOUSE_Taut is 1243 residues long, with 792 residues (63.72 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 5 long (>= 30 residues) disorder segments.
Segment 1 - Long (>= 30 residues) disordered segment
Segment is located between positions 303 and 533 in the sequence.
The segment is 231 residues long (18.58 % of the total sequence length).
Segment 2 - Long (>= 30 residues) disordered segment
Segment is located between positions 561 and 651 in the sequence.
The segment is 91 residues long (7.32 % of the total sequence length).
Segment 3 - Long (>= 30 residues) disordered segment
Segment is located between positions 669 and 951 in the sequence.
The segment is 283 residues long (22.77 % of the total sequence length).
Segment 4 - Long (>= 30 residues) disordered segment
Segment is located between positions 1050 and 1093 in the sequence.
The segment is 44 residues long (3.54 % of the total sequence length).
Segment 5 - Long (>= 30 residues) disordered segment
Segment is located between positions 1101 and 1243 in the sequence.
The segment is 143 residues long (11.50 % of the total sequence length). |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Mouse ciliary protein.
Serine/threonine kinase that acts as a key regulator of ciliogenesis. |
References for function | Goetz SC, Liem KF Jr, Anderson KV. The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. Cell. 2012 Nov 9;151(4):847-858. doi: 10.1016/j.cell.2012.10.010. PMID: 23141541; PMCID: PMC3496184. |
E.C. number | 2.7.11.1 |
Location of functional site(s) | |
Cellular location of function | cilium |
Comments | |
Function 2 |
Function description | regulates NFkappaB signaling |
References for function | McFie M, Koneva L, Collins I, Coveney CR, Clube AM, Chanalaris A, Vincent TL, Bezbradica JS, Sansom SN, Wann AK. Ciliary proteins specify the cell inflammatory response by tuning NFkB signaling, independently of primary cilia. Journal of Cell Science. 2020 Jan 1. PMID: 32503942 |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |