Protein Information

General Information
MoonProt ID466
First appeared in release3.0
Name(s)TTBK2 Tau-tubulin kinase 2. Recommended name: Tau-tubulin kinase 2 (EC:2.7.11.1) Alternative name(s): Protein bartleby
UniProt IDQ3UVR3 (TTBK2_MOUSE)
GO termsGO:0021549 ciliary basal body GO:0021681 ciliary transition zone GO:0021935 centriole GO:0060271 cilium assembly GO:0036064 peptidyl-serine phosphorylation GO:0035869 smoothened signaling pathway GO:0018105 nucleus GO:0005737 protein serine/threonine kinase activity GO:0005634 cell projection GO:0004674 transferase activity GO:0036064 kinase activity GO:0035869 cell projection organization GO:0005814 cilium GO:0060271 cytoplasm GO:0018105 nucleotide binding GO:0004674 ATP binding GO:0004672 cytoskeleton GO:0005524 phosphorylation GO:0006468 cytosol
Organisms for which functions have been demonstratedMus musculus (Mouse, mammal)
Sequence length1243 amino acids
FASTA sequence>sp|Q3UVR3|TTBK2_MOUSE Tau-tubulin kinase 2 OS=Mus musculus OX=10090 GN=Ttbk2 PE=1 SV=1 MSGGGEQPDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGKQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCFMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSTFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKSGTDGSLTTTTTSATPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIPVGVSPDKLPGSLGHPRPQEKDVWEEMDINKNKIKLGICKAATEEENSHGQVNGILNAPSLGSPIRVRSEITQPDRDVPLVRKLRSIHSFELEKRLTLEPKPDTDKFLETCMEKMQKDSSAGKEPVPPALPHKPCVPVVTHTDHIWHYDDEYLPDASKPASANTPEQADGGGSNGFIAVNLSSCKQEVDSKEWVIVDKEQDLQDFRTNEVLGHKTTGSPSDEEPEVLQVLEGSPQDEKIQVGPWTDNHHLKKESSGVVLALSAECPATAASELYTDRLDLQAGAASQFITVTPTSPMEAQAEGPLTAITIPRPSVASTQSTSGSFHYGPQPEKKDLQPLEPTVELYSPRENFSGLVVTEGELASGGSRVDLGLQIDHTGHDMLPNMRDGDTSQDLGPKDPPDHNRLAVKEFEHLPGETEERSLLLGSENEDERLSKGQHCIEVSSPGELVTAERAQLAATEPLHVSETQNCSVLPNQDKTHEIMKLLAVGTSEISPQAIDPHAEGQIGQMAAMQKNKLFKDDGIQSESLPRQQGDLSAFLHQEGKREKVVPRNGELYHCVSENEHGPPTRKDMLRSSFVTRHSRIPVLAQEIDSTFESSSAISAKEKLLQKKAYQPEIVKLLVEKRQFKSFLGDLSSASDKLIEEKLAAVPVPFSEEEVFAPFSRLAADSHLSRSVEDSFLSPIISQARKSKIPRPVSWVSTDQINGSASPQFLPRPPPGKPPVRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKSRSTTQCKSPGSPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGPKGSGSLHHHSTSSKTPPGKSKPASKLSR
Structure Information
PDB IDNA
Quaternary structureNA
SCOP
CATH
TM Helix Predictionno TM helices # sp|Q3UVR3|TTBK2_MOUSE Number of predicted TMHs: 0 # sp|Q3UVR3|TTBK2_MOUSE Exp number of AAs in TMHs: 0.0692 # sp|Q3UVR3|TTBK2_MOUSE Exp number, first 60 AAs: 0.0002 # sp|Q3UVR3|TTBK2_MOUSE Total prob of N-in: 0.00383 sp|Q3UVR3|TTBK2_MOUSE TMHMM2.0 outside 1 1243
DisProt Annotation
Predicted Disorder RegionsUse FASTA sequence on MFDp2 webserver. spQ3UVR3TTBK2_MOUSE_Taut is 1243 residues long, with 792 residues (63.72 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 5 long (>= 30 residues) disorder segments. Segment 1 - Long (>= 30 residues) disordered segment Segment is located between positions 303 and 533 in the sequence. The segment is 231 residues long (18.58 % of the total sequence length). Segment 2 - Long (>= 30 residues) disordered segment Segment is located between positions 561 and 651 in the sequence. The segment is 91 residues long (7.32 % of the total sequence length). Segment 3 - Long (>= 30 residues) disordered segment Segment is located between positions 669 and 951 in the sequence. The segment is 283 residues long (22.77 % of the total sequence length). Segment 4 - Long (>= 30 residues) disordered segment Segment is located between positions 1050 and 1093 in the sequence. The segment is 44 residues long (3.54 % of the total sequence length). Segment 5 - Long (>= 30 residues) disordered segment Segment is located between positions 1101 and 1243 in the sequence. The segment is 143 residues long (11.50 % of the total sequence length).
Connections to Disease
OMIM ID
Function 1
Function descriptionMouse ciliary protein. Serine/threonine kinase that acts as a key regulator of ciliogenesis.
References for functionGoetz SC, Liem KF Jr, Anderson KV. The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. Cell. 2012 Nov 9;151(4):847-858. doi: 10.1016/j.cell.2012.10.010. PMID: 23141541; PMCID: PMC3496184.
E.C. number2.7.11.1
Location of functional site(s)
Cellular location of functioncilium
Comments
Function 2
Function descriptionregulates NFkappaB signaling
References for functionMcFie M, Koneva L, Collins I, Coveney CR, Clube AM, Chanalaris A, Vincent TL, Bezbradica JS, Sansom SN, Wann AK. Ciliary proteins specify the cell inflammatory response by tuning NFkB signaling, independently of primary cilia. Journal of Cell Science. 2020 Jan 1. PMID: 32503942
E.C. number
Location of functional site(s)
Cellular location of functioncytoplasm
Comments