Protein Information

General Information
MoonProt ID467
First appeared in release3.0
Name(s)NPHP4 Nephrocystin-4. Recommended name: Nephrocystin-4 Alternative name(s): Nephroretinin
UniProt IDP59240 (NPHP4_MOUSE)
GO termsGO:0005911 cell-cell junction GO:0030054 cell junction GO:0042995 cell projection GO:0005923 bicellular tight junction GO:0005856 cytoskeleton GO:0005929 cilium GO:0005737 cytoplasm GO:0005815 microtubule organizing center
Organisms for which functions have been demonstratedMus musculus (Mouse, mammal)
Sequence length1425 amino acids
FASTA sequence>sp|P59240|NPHP4_MOUSE Nephrocystin-4 OS=Mus musculus OX=10090 GN=Nphp4 PE=1 SV=2 MGDWHRAFTQNTLVPPHPQRARQLGKESTAFQCILKWLDGPLIKQGILDMLSELECHLRVTLFDVTYKHFFGRTWKTTVKPTNQPSKQPPRITFNEPLYFHTTLSHPSIVAVVEVVTEGRKRDGTLQLLSCGFGILRIFGNKPESPTSAAQDKRLRLYHGTPRALLHPLLQDPIEQNKFMRLMENCSLQYTLKPHPPLEPAFHLLPENLLVSGFQQIPGLLPPHGDTGDALRKPRFQKPTTWHLDDLFFTLYPSLEKFEEELVQLLISDREGVGLLDSGTLEVLERRLHVCVHNGLGFVQRPQVVVLVPEMDVALTRSASFSRKISASSKNSSGNQALVLRSHLRLPEMVSHPAFAIVFQLEYVFNSPSGADGGASSPTSISSVACMHMVRWAVWNPDLEVGPGKVTLPLQGGVQQNPSRCLVYKVPSASMSSEEVKQVESGTIQFQFSLSSDGPTEHANGPRVGRRSSRKMPASPSGTPAPAARDLAATQDSPVGPGLSLSQLTASPLSPALQSSSKPPLQPPDSSQSPEGPQLQAESVLESRVSHLEADLSQPASLQGTPAVEHLQELPFTPLHAPIVVGAQTRSSRSQLSRAAMVLLQSSGFPEILDASQQPVEAVNPIDPVRFNPQKEESDCLRGNEIVLQFLAFSRAAQDCPGTPWPQTVYFTFQFYRFPPETTPRLQLVKLDGTGKSGSGSLSHILVPINKDGSFDAGSPGLQLRYMVDPGFLKPGEQRWFAHYLAAQTLQVDVWDGDSLLLIGSAGVQMKHLLRQGRPAVQVSHELEVVATEYEQEMMAVSGDVAGFGSVKPIGVHTVVKGRLHLTLANVGHACEPRARGSNLLPPSRSRVISNDGASFFSGGSLLIPGGPKRKRVVQAQRLADVDSELAAMLLTHTRAGQGPQAAGQEADAVHKRKLERMRLVRLQEAGGDSDSRRISLLAQHSVRAQHSRDLQVIDAYRERTKAESIAGVLSQAITTHHTLYATLGTAEFFEFALKNPHNTQHTVAIEIDSPELSIILDSQEWRYFKEATGLHTPLEEDMFHLRGSLAPQLYLRPRETAHIPLKFQSFSVGPLAPTQAPAEVITEKDAESGPLWKCSAMPTKHAKVLFRVETGQLIAVLCLTVEPQPHVVDQVFRFYHPELTFLKKAIRLPPWHTLPGAPVGMPGEDPPVHVRCSDPNVICEAQNVGPGEPRDVFLKVASGPSPEIKDFFVVIYADRWLAVPVQTWQVCLHSLQRVDVSCVAGQLTRLSLVLRGTQTVRKVRAFTSHPQELKTDPAGVFVLPPHGVQDLHVGVRPRRAGSRFVHLNLVDIDYHQLVASWLVCLSCRQPLISKAFEITMAAGDEKGTNKRITYTNPYPSRRTYRLHSDRPELLRFKEDSFQVAGGETYTIGLRFLPSGSAGQEEILIYINDHEDKNEETFCVKVLYQ
Structure Information
PDB IDNA
Quaternary structureNA
SCOP
CATH
TM Helix Predictionno TM helices # sp|P59240|NPHP4_MOUSE Number of predicted TMHs: 0 # sp|P59240|NPHP4_MOUSE Exp number of AAs in TMHs: 0.01023 # sp|P59240|NPHP4_MOUSE Exp number, first 60 AAs: 0.00019 # sp|P59240|NPHP4_MOUSE Total prob of N-in: 0.00043 sp|P59240|NPHP4_MOUSE TMHMM2.0 outside 1 1425
DisProt Annotation
Predicted Disorder RegionsUse FASTA sequence on MFDp2 webserver. spP59240NPHP4_MOUSE_Neph is 1425 residues long, with 321 residues (22.53 %) predicted as disordered. The protein has 6 short (< 30 residues) disorder segments and 2 long (>= 30 residues) disorder segments. Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 81 and 93 in the sequence. The segment is 13 residues long (0.91 % of the total sequence length). Segment 2 - Short (< 30 residues) disordered segment Segment is located between positions 143 and 157 in the sequence. The segment is 15 residues long (1.05 % of the total sequence length). Segment 3 - Short (< 30 residues) disordered segment Segment is located between positions 324 and 328 in the sequence. The segment is 5 residues long (0.35 % of the total sequence length). Segment 4 - Long (>= 30 residues) disordered segment Segment is located between positions 414 and 636 in the sequence. The segment is 223 residues long (15.65 % of the total sequence length). Segment 5 - Long (>= 30 residues) disordered segment Segment is located between positions 834 and 865 in the sequence. The segment is 32 residues long (2.25 % of the total sequence length). Segment 6 - Short (< 30 residues) disordered segment Segment is located between positions 899 and 905 in the sequence. The segment is 7 residues long (0.49 % of the total sequence length). Segment 7 - Short (< 30 residues) disordered segment Segment is located between positions 922 and 940 in the sequence. The segment is 19 residues long (1.33 % of the total sequence length). Segment 8 - Short (< 30 residues) disordered segment Segment is located between positions 1082 and 1088 in the sequence. The segment is 7 residues long (0.49 % of the total sequence length).
Connections to Disease
OMIM ID
Function 1
Function descriptionMouse ciliary protien. Required for building functional cilia.
References for functionMollet G, Salomon R, Gribouval O, Silbermann F, Bacq D, Landthaler G, Milford D, Nayir A, Rizzoni G, Antignac C, Saunier S. The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin. Nat Genet. 2002 Oct;32(2):300-5. doi: 10.1038/ng996. Epub 2002 Sep 9. Erratum in: Nat Genet 2002 Nov;32(3):459. PMID: 12244321.
E.C. number2.7.1.153
Location of functional site(s)
Cellular location of functioncilium
Comments
Function 2
Function descriptionregulates NFkappaB signaling
References for functionMcFie M, Koneva L, Collins I, Coveney CR, Clube AM, Chanalaris A, Vincent TL, Bezbradica JS, Sansom SN, Wann AK. Ciliary proteins specify the cell inflammatory response by tuning NFkB signaling, independently of primary cilia. Journal of Cell Science. 2020 Jan 1. PMID: 32503942
E.C. number
Location of functional site(s)
Cellular location of functioncytoplasm
Comments