| General Information |
| MoonProt ID | 468 |
| First appeared in release | 3.0 |
| Name(s) | PI3Kgamma
Recommended name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC:2.7.1.153)
Short name:
PI3-kinase subunit gamma
Short name:
PI3K-gamma
Short name:
PI3Kgamma
Short name:
PtdIns-3-kinase subunit gamma
Alternative name(s):
Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma
Short name:
PtdIns-3-kinase subunit p110-gamma
Short name:
p110gamma
Phosphoinositide-3-kinase catalytic gamma polypeptide
Serine/threonine protein kinase PIK3CG (EC:2.7.11.1)
p120-PI3K |
| UniProt ID | Q9JHG7 (PK3CG_MOUSE) |
| GO terms | GO:0001525 angiogenesis
GO:0016301 kinase activity
GO:0002376 immune system process
GO:0016740 transferase activity
GO:0005524 ATP binding
GO:0016310 phosphorylation
GO:0006897 endocytosis
GO:0005737 cytoplasm
GO:0004674 protein serine/threonine kinase activity
GO:0006954 inflammatory response
GO:0006935 chemotaxis
GO:0016020 membrane
GO:0005886 plasma membrane
GO:0000166 nucleotide binding
GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity |
| Organisms for which functions have been demonstrated | Mus musculus (Mouse, mammal) |
| Sequence length | 1102 amino acids |
| FASTA sequence | >sp|Q9JHG7|PK3CG_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform OS=Mus musculus OX=10090 GN=Pik3cg PE=1 SV=2
MELENYEQPVVLREDNLRRRRRMKPRSAAGSLSSMELIPIEFVLPTSQRISKTPETALLHVAGHGNVEQMKAQVWLRALETSVAAEFYHRLGPDQFLLLYQKKGQWYEIYDRYQVVQTLDCLHYWKLMHKSPGQIHVVQRHVPSEETLAFQKQLTSLIGYDVTDISNVHDDELEFTRRRLVTPRMAEVAGRDAKLYAMHPWVTSKPLPDYLSKKIANNCIFIVIHRGTTSQTIKVSADDTPGTILQSFFTKMAKKKSLMNISESQSEQDFVLRVCGRDEYLVGETPLKNFQWVRQCLKNGDEIHLVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFAEEVLWNVWLEFGIKIKDLPKGALLNLQIYCCKTPSLSSKASAETPGSESKGKAQLLYYVNLLLIDHRFLLRHGDYVLHMWQISGKAEEQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHRPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREIWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLQDFTQQVHVIEMLQKVTIDIKSLSAEKYDVSSQVISQLKQKLESLQNSNLPESFRVPYDPGLKAGTLVIEKCKVMASKKKPLWLEFKCADPTVLSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAQIQQSTVGNTGAFKDEVLNHWLKEKCPIEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMISETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGSSGKKTSPHFQKFQDVCVRAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKSEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | Heterodimer of a catalytic subunit PIK3CG and a PIK3R5 or PIK3R6 regulatory subunit. |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices
# sp|Q9JHG7|PK3CG_MOUSE Number of predicted TMHs: 0
# sp|Q9JHG7|PK3CG_MOUSE Exp number of AAs in TMHs: 6.36849
# sp|Q9JHG7|PK3CG_MOUSE Exp number, first 60 AAs: 0.10212
# sp|Q9JHG7|PK3CG_MOUSE Total prob of N-in: 0.00525
sp|Q9JHG7|PK3CG_MOUSE TMHMM2.0 outside 1 1102 |
| DisProt Annotation | |
| Predicted Disorder Regions | Use FASTA sequence on MFDp2 webserver.
spQ9JHG7PK3CG_MOUSE_Phos is 1102 residues long, with 50 residues (4.54 %) predicted as disordered. The protein has 4 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments.
Segment 1 - Short (< 30 residues) disordered segment
Segment is located between positions 1 and 15 in the sequence.
The segment is 15 residues long (1.36 % of the total sequence length).
Segment 2 - Short (< 30 residues) disordered segment
Segment is located between positions 440 and 454 in the sequence.
The segment is 15 residues long (1.36 % of the total sequence length).
Segment 3 - Short (< 30 residues) disordered segment
Segment is located between positions 529 and 544 in the sequence.
The segment is 16 residues long (1.45 % of the total sequence length).
Segment 4 - Short (< 30 residues) disordered segment
Segment is located between positions 1099 and 1102 in the sequence.
The segment is 4 residues long (0.36 % of the total sequence length). |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | phosphoinositide 3-kinase |
| References for function | Sasaki T, Irie-Sasaki J, Jones RG, Oliveira-dos-Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, Joza N, Mak TW, Ohashi PS, Suzuki A, Penninger JM. Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science. 2000 Feb 11;287(5455):1040-6. doi: 10.1126/science.287.5455.1040. PMID: 10669416. |
| E.C. number | 2.7.1.153 |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | regulator of phosphodiesterase 4, a non-catalytic function |
| References for function | Lupieri A, Blaise R, Ghigo A, Smirnova N, Sarthou MK, Malet N, Limon I, Vincent P, Hirsch E, Gayral S, Ramel D, Laffargue M. A non-catalytic function of PI3K-gamma drives smooth muscle cell proliferation after arterial damage. J Cell Sci. 2020 Jul 9;133(13):jcs245969. doi: 10.1242/jcs.245969. PMID: 32482794. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |