| General Information |
| MoonProt ID | 469 |
| First appeared in release | 3.0 |
| Name(s) | phosphoglucosamine mutase
gene: glmM |
| UniProt ID | Q8Y5E6 (GLMM_LISMO) |
| GO terms | GO:0046872 metal ion binding
GO:0016853 isomerase activity
GO:0008966 phosphoglucosamine mutase activity
GO:0000287 magnesium ion binding |
| Organisms for which functions have been demonstrated | Listeria monocytogenes (Gram positive bacterium, causes listeriosis, septicemia, meningitis) |
| Sequence length | 450 amino acids |
| FASTA sequence | >sp|Q8Y5E6|GLMM_LISMO Phosphoglucosamine mutase OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) OX=169963 GN=glmM PE=3 SV=1
MGKYFGTDGVRGVANSELTPELAFRLGRMGGYVLTRHVGEHPRVLVARDTRISGEMLESALIAGLVSVGIEVMRLGVISTPGVAYLTKAQGASASVMISASHNPVDDNGIKFFGSDGFKLSDDQEEEIEQLLDTAEDTLPRPSGEGLGTVSDYFEGKQKYIQYLKQTIENDFNGYHIALDCANGATSGLATHLFADLDADISSMGASPNGLNINDGVGSTHPEALAAFVLDKKADVGLAFDGDGDRVIAIDEIGQIVDGDKIMFICAKYLREQGLLNNNTIVSTVMSNLGFYKGLKELEIEDVQTAVGDRYVVEAMREGNYNLGGEQSGHIIFLDHNTTGDGLLSGIQLINVMKATGKKLSELAAEMKTFPQKLENIRVSDKNHVTDNPKVSKVIDEVEAEMAGNGRVLVRPSGTEPLVRVMVEAATKEETDEYCERISAVVRSEMALND |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices
# sp|Q8Y5E6|GLMM_LISMO Number of predicted TMHs: 0
# sp|Q8Y5E6|GLMM_LISMO Exp number of AAs in TMHs: 0.478909999999999999
# sp|Q8Y5E6|GLMM_LISMO Exp number, first 60 AAs: 0.07193
# sp|Q8Y5E6|GLMM_LISMO Total prob of N-in: 0.02244
sp|Q8Y5E6|GLMM_LISMO TMHMM2.0 outside 1 450 |
| DisProt Annotation | |
| Predicted Disorder Regions | Use FASTA sequence on MFDp2 webserver.
spQ8Y5E6GLMM_LISMO_Phosp is 450 residues long, with 0 residues (0.00 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments. |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | phosphoglucosamine mutase.
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. |
| References for function | Mengin-Lecreulx D, van Heijenoort J. Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli. J Biol Chem. 1996 Jan 5;271(1):32-9. doi: 10.1074/jbc.271.1.32. PMID: 8550580. |
| E.C. number | 5.4.2.10 |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | Forms a complex with CdaA and inhibits the diadenylate cyclaseactivity. |
| References for function | Gibhardt J, Heidemann JL, Bremenkamp R, Rosenberg J, Seifert R, Kaever V, Ficner R, Commichau FM. An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c-di-AMP in Listeria monocytogenes. Environ Microbiol. 2020 Jul;22(7):2771-2791. doi: 10.1111/1462-2920.15008. Epub 2020 Apr 21. PMID: 32250026. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |