General Information |
MoonProt ID | 47 |
First appeared in release | 1.0 |
Name(s) | fructose-1,6-bisphosphate aldolase
Fructose-bisphosphate aldolase
Gene Name: fba |
UniProt ID | F0N9L0 (F0N9L0_NEIMN), Unreviewed |
GO terms | GO:0005975 carbohydrate metabolic process
GO:0006096 glycolysis
GO:0003824 catalytic activity
GO:0004332 fructose-bisphosphate aldolase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0016832 aldehyde-lyase activity |
Organisms for which functions have been demonstrated | Neisseria meningitidis (Gram negative bacterium, causes meningitis) |
Sequence length | 354 |
FASTA sequence | >gi|254804307|ref|YP_003082528.1| fructose-1,6-bisphosphate aldolase [Neisseria meningitidis alpha14]
MALVSMRQLLDHAAENSYGLPAFNVNNLEQMRAIMEAADQVNAPVIVQASAGARKYAGAPFLRHLILAAVEEFPHIPVVMHQDHGASPDVCQRSIQLGFSSVMMDGSLMEDGKTPSSYEYNVNATRTVVNFSHACGVSVEGEIGVLGNLETGEAGEEDGVGAVGKLSHDQMLTSVEDAVRFVKDTGVDALAIAVGTSHGAYKFTRPPTGDVLRIDRIKEIHQALPNTHIVMHGSSSVPQEWLKVINEYGGNIGETYGVPVEEIVEGIKHGVRKVNIDTDLRLASTGAVRRYLAENPSDFDPRKYLSKTIEAMKQICLDRYLAFGCEGQAGKIKPVSLEKMANRYAKGELNQIVK |
Structure Information |
PDB ID | 5U4N |
Quaternary structure | |
SCOP | TIM beta/alpha-barrel |
CATH | 3.20.20.70 |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | fructose-1,6-bisphosphate aldolase, enzyme |
References for function | |
E.C. number | 4.1.2.13 |
Location of functional site(s) | |
Cellular location of function | cytosol |
Comments | |
Function 2 |
Function description | adhesin to human cells |
References for function | Tunio SA, Oldfield NJ, Berry A, AlaAldeen DA, Wooldridge KG, Turner DP. The moonlighting protein fructose-1, 6-bisphosphate aldolase of Neisseria meningitidis: surface localization and role in host cell adhesion.
Mol Microbiol. 2010 May;76(3):605-15. doi: 10.1111/j.1365-2958.2010.07098.x. Epub 2010 Feb 28.
PMID: 20199602 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cell surface |
Comments | |