Protein Information

General Information
MoonProt ID47
First appeared in release1.0
Name(s)fructose-1,6-bisphosphate aldolase Fructose-bisphosphate aldolase Gene Name: fba
UniProt IDF0N9L0 (F0N9L0_NEIMN), Unreviewed
GO termsGO:0005975 carbohydrate metabolic process GO:0006096 glycolysis GO:0003824 catalytic activity GO:0004332 fructose-bisphosphate aldolase activity GO:0008270 zinc ion binding GO:0016829 lyase activity GO:0016832 aldehyde-lyase activity
Organisms for which functions have been demonstratedNeisseria meningitidis (Gram negative bacterium, causes meningitis)
Sequence length354
FASTA sequence>gi|254804307|ref|YP_003082528.1| fructose-1,6-bisphosphate aldolase [Neisseria meningitidis alpha14] MALVSMRQLLDHAAENSYGLPAFNVNNLEQMRAIMEAADQVNAPVIVQASAGARKYAGAPFLRHLILAAVEEFPHIPVVMHQDHGASPDVCQRSIQLGFSSVMMDGSLMEDGKTPSSYEYNVNATRTVVNFSHACGVSVEGEIGVLGNLETGEAGEEDGVGAVGKLSHDQMLTSVEDAVRFVKDTGVDALAIAVGTSHGAYKFTRPPTGDVLRIDRIKEIHQALPNTHIVMHGSSSVPQEWLKVINEYGGNIGETYGVPVEEIVEGIKHGVRKVNIDTDLRLASTGAVRRYLAENPSDFDPRKYLSKTIEAMKQICLDRYLAFGCEGQAGKIKPVSLEKMANRYAKGELNQIVK
Structure Information
PDB ID5U4N
Quaternary structure
SCOPTIM beta/alpha-barrel
CATH3.20.20.70
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder Regions
Connections to Disease
OMIM ID
Function 1
Function descriptionfructose-1,6-bisphosphate aldolase, enzyme
References for function
E.C. number4.1.2.13
Location of functional site(s)
Cellular location of functioncytosol
Comments
Function 2
Function descriptionadhesin to human cells
References for functionTunio SA, Oldfield NJ, Berry A, AlaAldeen DA, Wooldridge KG, Turner DP. The moonlighting protein fructose-1, 6-bisphosphate aldolase of Neisseria meningitidis: surface localization and role in host cell adhesion. Mol Microbiol. 2010 May;76(3):605-15. doi: 10.1111/j.1365-2958.2010.07098.x. Epub 2010 Feb 28. PMID: 20199602
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncell surface
Comments