| General Information |
| MoonProt ID | 472 |
| First appeared in release | 3.0 |
| Name(s) | MIPS
myo-inositol phosphate synthase (MIPS, MIPS1: At4g39800).
Recommended name:
Inositol-3-phosphate synthase isozyme 1 (EC:5.5.1.4)
Short name:
AtIPS1
Short name:
MIP synthase 1
Alternative name(s):
Myo-inositol 1-phosphate synthase 1
Short name:
AtMIPS 1
Short name:
MI-1-P synthase 1 |
| UniProt ID | P42801 (INO1_ARATH) |
| GO terms | GO:0006021 inositol biosynthetic process
GO:0016853 isomerase activity
GO:0008654 phospholipid biosynthetic process
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006629 lipid metabolic process
GO:0004512 inositol-3-phosphate synthase activity |
| Organisms for which functions have been demonstrated | Arabidopsis thaliana (Mouse-ear cress, a plant) |
| Sequence length | 511 amino acids |
| FASTA sequence | >sp|P42801|INO1_ARATH Inositol-3-phosphate synthase isozyme 1 OS=Arabidopsis thaliana OX=3702 GN=IPS1 PE=1 SV=3
MFIESFKVESPNVKYTENEIHSVYDYETTEVVHEKTVNGTYQWIVKPKTVKYDFKTDIRVPKLGVMLVGLGGNNGSTLTAGVIANKEGISWATKDKVQQANYFGSLTQASSIRVGSFNGEEIYAPFKSLLPMVNPDDVVFGGWDISDMNLADAMARARVLDIDLQKQLRPYMENIVPLPGIFDPDFIAANQGSRANHVIKGTKKEQVDHIIKDMREFKEKNKVDKVVVLWTANTERYSNVVVGMNDTMENLMESVDRDEAEISPSTLYAIACVLEGIPFINGSPQNTFVPGLIDMAIRNNVLIGGDDFKSGQTKMKSVLVDFLVGAGIKPTSIVSYNHLGNNDGMNLSAPQTFRSKEISKSNVVDDMVASNGILFEPGEHPDHVVVIKYVPYVADSKRAMDEYTSEIFMGGKNTIVMHNTCEDSLLAAPIILDLVLLAELSTRIQFKSEGEGKFHSFHPVATILSYLTKAPLVPPGTPVINALSKQRAMLENIMRACVGLAPENNMIMEFK |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices
# sp|P42801|INO1_ARATH Number of predicted TMHs: 0
# sp|P42801|INO1_ARATH Exp number of AAs in TMHs: 0.24507
# sp|P42801|INO1_ARATH Exp number, first 60 AAs: 0.00102
# sp|P42801|INO1_ARATH Total prob of N-in: 0.00607
sp|P42801|INO1_ARATH TMHMM2.0 outside 1 511 |
| DisProt Annotation | |
| Predicted Disorder Regions | Use FASTA sequence on MFDp2 webserver.
spP42801INO1_ARATH_Inosi is 511 residues long, with 0 residues (0.00 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments. |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | myo-inositol phosphate synthase. |
| References for function | Donahue JL, Alford SR, Torabinejad J, Kerwin RE, Nourbakhsh A, Ray WK, Hernick M, Huang X, Lyons BM, Hein PP, Gillaspy GE. The Arabidopsis thaliana Myo-inositol 1-phosphate synthase1 gene is required for Myo-inositol synthesis and suppression of cell death. Plant Cell. 2010 Mar;22(3):888-903. doi: 10.1105/tpc.109.071779. Epub 2010 Mar 9. PMID: 20215587; PMCID: PMC2861443. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | Interact with the histone methyltransferases ATXR5 and ATXR6. |
| References for function | Latrasse D, Jégu T, Meng PH, Mazubert C, Hudik E, Delarue M, Charon C, Crespi M, Hirt H, Raynaud C, Bergounioux C, Benhamed M. Dual function of MIPS1 as a metabolic enzyme and transcriptional regulator. Nucleic Acids Res. 2013 Mar 1;41(5):2907-17. doi: 10.1093/nar/gks1458. Epub 2013 Jan 21. PMID: 23341037; PMCID: PMC3597657. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |