Protein Information

General Information
MoonProt ID473
First appeared in release3.0
Name(s)ADT2 Arogenate dehydratase/prephenate dehydratase 2, chloroplastic.
UniProt IDQ9SSE7 (AROD2_ARATH)
GO termsGO:0008652 cellular amino acid biosynthetic process GO:0016829 lyase activity GO:0009507 chloroplast GO:0009073 aromatic amino acid family biosynthetic process GO:0009536 plastid GO:0047769 arogenate dehydratase activity GO:0004664 prephenate dehydratase activity GO:0009570 chloroplast stroma GO:0009094 L-phenylalanine biosynthetic process
Organisms for which functions have been demonstratedArabidopsis thaliana (Mouse-ear cress, a plant)
Sequence length381 amino acids
FASTA sequence>sp|Q9SSE7|AROD2_ARATH Arogenate dehydratase/prephenate dehydratase 2, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=ADT2 PE=1 SV=1 MAMHTVRLSPATQLHGGISSNLSPPNRKPNNSIVRYGCGSSKRFRIVTVLASLRENDANGRDNSVRAMEVKKIFEDSPLLPKPLSSNQLTESVSNGSRVRVAYQGVRGAYSESAAEKAYPNCEAVPCEEFDTAFEAVERWLVDRAVLPIENSLGGSIHRNYDLLLRHNLHIVGEVKLAVRHCLLANHGVNIEDLRRVLSHPQALAQCENTLTKLGLVREAVDDTAGAAKQIAFENLNDAAAVASEKAAKIYGLNIVAKDIQDDCDNVTRFLMLAREPIIPGTNRLFKTSIVFSLEEGPGVLFKALAVFALRQINLTKIESRPLRKHPLRASGGLKYFDYLFYVDFEASMADEVAQNALRHLEEFATFLRVLGSYPVDTTML
Structure Information
PDB IDNA
Quaternary structureNA
SCOP
CATH
TM Helix Predictionno TM helices # sp|Q9SSE7|AROD2_ARATH Number of predicted TMHs: 0 # sp|Q9SSE7|AROD2_ARATH Exp number of AAs in TMHs: 0.06482 # sp|Q9SSE7|AROD2_ARATH Exp number, first 60 AAs: 0 # sp|Q9SSE7|AROD2_ARATH Total prob of N-in: 0.00898 sp|Q9SSE7|AROD2_ARATH TMHMM2.0 outside 1 381
DisProt Annotation
Predicted Disorder RegionsUse FASTA sequence on MFDp2 webserver. spQ9SSE7AROD2_ARATH_Arog is 381 residues long, with 31 residues (8.14 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 1 long (>= 30 residues) disorder segment. Segment 1 - Long (>= 30 residues) disordered segment Segment is located between positions 1 and 31 in the sequence. The segment is 31 residues long (8.14 % of the total sequence length).
Connections to Disease
OMIM ID
Function 1
Function descriptionarogenate dehydratase. Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine.
References for functionCho MH, Corea OR, Yang H, Bedgar DL, Laskar DD, Anterola AM, Moog-Anterola FA, Hood RL, Kohalmi SE, Bernards MA, Kang C, Davin LB, Lewis NG. Phenylalanine biosynthesis in Arabidopsis thaliana. Identification and characterization of arogenate dehydratases. J Biol Chem. 2007 Oct 19;282(42):30827-35. doi: 10.1074/jbc.M702662200. Epub 2007 Aug 28. PMID: 17726025.
E.C. number4.2.1.91
Location of functional site(s)
Cellular location of functionchloroplast stroma.
Comments
Function 2
Function descriptioncomponent of the chloroplast division machinery. .
References for functionBross CD, Howes TR, Abolhassani Rad S, Kljakic O, Kohalmi SE. Subcellular localization of Arabidopsis arogenate dehydratases suggests novel and non-enzymatic roles. J Exp Bot. 2017 Mar 1;68(7):1425-1440. doi: 10.1093/jxb/erx024. PMID: 28338876; PMCID: PMC5444438.
E.C. number
Location of functional site(s)
Cellular location of functionADT2 localizes in a ring around the equatorial plane of chloroplasts or to a chloroplast pole.
Comments