Protein Information

General Information
MoonProt ID474
First appeared in release3.0
Name(s)ADT5 Arogenate dehydratase 5, chloroplastic.
UniProt IDQ9FNJ8 (AROD5_ARATH)
GO termsGO:0008652 cellular amino acid biosynthetic process GO:0016829 lyase activity GO:0009507 chloroplast GO:0009536 plastid GO:0009094 L-phenylalanine biosynthetic process GO:0009073 aromatic amino acid family biosynthetic process GO:0047769 arogenate dehydratase activity GO:0009570 chloroplast stroma
Organisms for which functions have been demonstratedArabidopsis thaliana (Mouse-ear cress, a plant)
Sequence length425 amino acids
FASTA sequence>sp|Q9FNJ8|AROD5_ARATH Arogenate dehydratase 5, chloroplastic OS=Arabidopsis thaliana OX=3702 GN=ADT5 PE=1 SV=1 MQTISPAFSCDLKSVIQPNLTAKKARYSHVNGKRVSVRCSYRSESFSFPNGVGSSRADWQSSCAILASKVVSAENSSSVAVVNGHSNGSVDLSLVPSKSQHNGKPGLIQPLTITDLSPAPSHGSTLRVAYQGVPGAYSEAAAGKAYPNSEAIPCDQFDVAFQAVELWIADRAVLPVENSLGGSIHRNYDLLLRHRLHIVGEVQIPVHHCLLALPGVRTDCITRVISHPQALAQTEGSLNKLTPKAAIEAFHDTAAAAEYIAANNLHDTAAVASARAAELYGLQILADGIQDDAGNVTRFLMLARDPIIPRTDRPFKTSIVFAAQEHKGTSVLFKVLSAFAFRNISLTKIESRPHQNCPVRVVGDENVGTSKHFEYTFYVDFEASMAEARAQNALAEVQEYTSFLRVLGSYPMDMTPWSTLPSEDV
Structure Information
PDB IDNA
Quaternary structureNA
SCOP
CATH
TM Helix Predictionno TM helices
DisProt Annotation
Predicted Disorder RegionsUse FASTA sequence on MFDp2 webserver. spQ9FNJ8AROD5_ARATH_Arog is 425 residues long, with 24 residues (5.65 %) predicted as disordered. The protein has 3 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments. Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 1 and 12 in the sequence. The segment is 12 residues long (2.82 % of the total sequence length). Segment 2 - Short (< 30 residues) disordered segment Segment is located between positions 92 and 97 in the sequence. The segment is 6 residues long (1.41 % of the total sequence length). Segment 3 - Short (< 30 residues) disordered segment Segment is located between positions 420 and 425 in the sequence. The segment is 6 residues long (1.41 % of the total sequence length).
Connections to Disease
OMIM ID
Function 1
Function descriptionArogenate dehydratase.
References for functionCho MH, Corea OR, Yang H, Bedgar DL, Laskar DD, Anterola AM, Moog-Anterola FA, Hood RL, Kohalmi SE, Bernards MA, Kang C, Davin LB, Lewis NG. Phenylalanine biosynthesis in Arabidopsis thaliana. Identification and characterization of arogenate dehydratases. J Biol Chem. 2007 Oct 19;282(42):30827-35. doi: 10.1074/jbc.M702662200. Epub 2007 Aug 28. PMID: 17726025.
E.C. number4.2.1.91
Location of functional site(s)
Cellular location of functionchloroplast stroma.
Comments
Function 2
Function descriptiontranscriptional regulator.
References for functionBross CD, Howes TR, Abolhassani Rad S, Kljakic O, Kohalmi SE. Subcellular localization of Arabidopsis arogenate dehydratases suggests novel and non-enzymatic roles. J Exp Bot. 2017 Mar 1;68(7):1425-1440. doi: 10.1093/jxb/erx024. PMID: 28338876; PMCID: PMC5444438.
E.C. number
Location of functional site(s)
Cellular location of functionADT5 was also found in nuclei. ADT5 is transported to the nucleus via stromules.
Comments