Protein Information

General Information
MoonProt ID475
First appeared in release3.0
Name(s)EYA Developmental protein eyes absent. Recommended name: Developmental protein eyes absent (EC:3.1.3.48) Alternative name(s): Protein Clift
UniProt IDQ05201 (EYA_DROME)
GO termsGO:0016787 hydrolase activity GO:0004721 phosphoprotein phosphatase activity GO:0046872 metal ion binding GO:0007275 multicellular organism development GO:0005634 nucleus GO:0004725 protein tyrosine phosphatase activity GO:0007455 eye-antennal disc morphogenesis
Organisms for which functions have been demonstratedDrosophila melanogaster (fruit fly, an insect)
Sequence length766 amino acids
FASTA sequence>sp|Q05201|EYA_DROME Developmental protein eyes absent OS=Drosophila melanogaster OX=7227 GN=eya PE=1 SV=1 MVTLMPYNYAAPRCGLIDKMIEPKVKRPKTDHTDTHERNRLCNLSQQQQQQQPQQQQTHQQQQQQQQQSHQQSHSSTVLASNGPSSAGAGMGVGVGGGGGSGGGVGGGVGQCSPLGLPPQSQPLQPTIGSLASLSGHYSNGNANPNVNSSSCSLATASSFAQSAGSSFSTYQQAGGTSGGVSGEDGVVGGATVMSHWTHDGTGSSAAVKSESRSPGQVHASLDNGSVAGSNLYGCSSASNPLDGGAVAVNSSAVAAAAAAVYDGKHDYYYYNSMQQYTPPPFYSGYGTPYAAATAARQAKMEPGAAAAAAAYLTPSYAASGNNNSQLYSSPYAGYNNFGQQDYGGYYNEQYGNYYSPANYSPYAVSSPSSSASHGHGFHVAASSNLSESPTDTHSTTPVHQTTHSPHSPLPISPSTGSGIGPLGNVSAAAAAAALNSSGGSSVGTAGSGGVATSKTTPTGKTGRARGRRHQQPSPTRSTASDTGNSEAVKPPERVFVWDLDETLIIFHTLLSGSYANRYTKDHSSLMTIAFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDNGQDLSAYNFATDGFHTNTPPGAPPNLCLPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGTLLGPGKREAWLQIRSEIEVATDNWATLALKCLSMISQRENCVNVLVTSTQLAPALAKVLLFGLGGIFNIENIYSAHKIGHETCYERIVTRFGRKSTYVVIGDGNEEETAAKAMNFPFWRISAHSDIRALYTALDMGFL
Structure Information
PDB IDNA
Quaternary structureNA
SCOP
CATH
TM Helix Predictionno TM helices # sp|Q05201|EYA_DROME Number of predicted TMHs: 0 # sp|Q05201|EYA_DROME Exp number of AAs in TMHs: 0.48511 # sp|Q05201|EYA_DROME Exp number, first 60 AAs: 0 # sp|Q05201|EYA_DROME Total prob of N-in: 0.00175 sp|Q05201|EYA_DROME TMHMM2.0 outside 1 766
DisProt Annotation
Predicted Disorder RegionsUse FASTA sequence on MFDp2 webserver. spQ05201EYA_DROME_Develo is 766 residues long, with 324 residues (42.30 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 3 long (>= 30 residues) disorder segments. Segment 1 - Long (>= 30 residues) disordered segment Segment is located between positions 19 and 76 in the sequence. The segment is 58 residues long (7.57 % of the total sequence length). Segment 2 - Long (>= 30 residues) disordered segment Segment is located between positions 102 and 235 in the sequence. The segment is 134 residues long (17.49 % of the total sequence length). Segment 3 - Long (>= 30 residues) disordered segment Segment is located between positions 364 and 495 in the sequence. The segment is 132 residues long (17.23 % of the total sequence length).
Connections to Disease
OMIM ID
Function 1
Function descriptiontranscriptional coactivator.
References for functionOhto H, Kamada S, Tago K, Tominaga SI, Ozaki H, Sato S, Kawakami K. Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. Mol Cell Biol. 1999 Oct;19(10):6815-24. doi: 10.1128/mcb.19.10.6815. PMID: 10490620; PMCID: PMC84678.
E.C. number
Location of functional site(s)
Cellular location of functionnucleus
Comments
Function 2
Function descriptiontyrosine phosphatase
References for functionRebay I, Silver SJ, Tootle TL. New vision from Eyes absent: transcription factors as enzymes. Trends Genet. 2005 Mar;21(3):163-71. doi: 10.1016/j.tig.2005.01.005. PMID: 15734575.
E.C. number
Location of functional site(s)
Cellular location of function
Comments