| General Information |
| MoonProt ID | 475 |
| First appeared in release | 3.0 |
| Name(s) | EYA
Developmental protein eyes absent.
Recommended name:
Developmental protein eyes absent (EC:3.1.3.48)
Alternative name(s):
Protein Clift |
| UniProt ID | Q05201 (EYA_DROME) |
| GO terms | GO:0016787 hydrolase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0046872 metal ion binding
GO:0007275 multicellular organism development
GO:0005634 nucleus
GO:0004725 protein tyrosine phosphatase activity
GO:0007455 eye-antennal disc morphogenesis |
| Organisms for which functions have been demonstrated | Drosophila melanogaster (fruit fly, an insect) |
| Sequence length | 766 amino acids |
| FASTA sequence | >sp|Q05201|EYA_DROME Developmental protein eyes absent OS=Drosophila melanogaster OX=7227 GN=eya PE=1 SV=1
MVTLMPYNYAAPRCGLIDKMIEPKVKRPKTDHTDTHERNRLCNLSQQQQQQQPQQQQTHQQQQQQQQQSHQQSHSSTVLASNGPSSAGAGMGVGVGGGGGSGGGVGGGVGQCSPLGLPPQSQPLQPTIGSLASLSGHYSNGNANPNVNSSSCSLATASSFAQSAGSSFSTYQQAGGTSGGVSGEDGVVGGATVMSHWTHDGTGSSAAVKSESRSPGQVHASLDNGSVAGSNLYGCSSASNPLDGGAVAVNSSAVAAAAAAVYDGKHDYYYYNSMQQYTPPPFYSGYGTPYAAATAARQAKMEPGAAAAAAAYLTPSYAASGNNNSQLYSSPYAGYNNFGQQDYGGYYNEQYGNYYSPANYSPYAVSSPSSSASHGHGFHVAASSNLSESPTDTHSTTPVHQTTHSPHSPLPISPSTGSGIGPLGNVSAAAAAAALNSSGGSSVGTAGSGGVATSKTTPTGKTGRARGRRHQQPSPTRSTASDTGNSEAVKPPERVFVWDLDETLIIFHTLLSGSYANRYTKDHSSLMTIAFRMEEMVFNMADTHFFFNEIEECDQVHIDDVSSDDNGQDLSAYNFATDGFHTNTPPGAPPNLCLPTGVRGGVDWMRKLAFRYRKIKDIYNSYRGNVGTLLGPGKREAWLQIRSEIEVATDNWATLALKCLSMISQRENCVNVLVTSTQLAPALAKVLLFGLGGIFNIENIYSAHKIGHETCYERIVTRFGRKSTYVVIGDGNEEETAAKAMNFPFWRISAHSDIRALYTALDMGFL |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices
# sp|Q05201|EYA_DROME Number of predicted TMHs: 0
# sp|Q05201|EYA_DROME Exp number of AAs in TMHs: 0.48511
# sp|Q05201|EYA_DROME Exp number, first 60 AAs: 0
# sp|Q05201|EYA_DROME Total prob of N-in: 0.00175
sp|Q05201|EYA_DROME TMHMM2.0 outside 1 766 |
| DisProt Annotation | |
| Predicted Disorder Regions | Use FASTA sequence on MFDp2 webserver.
spQ05201EYA_DROME_Develo is 766 residues long, with 324 residues (42.30 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 3 long (>= 30 residues) disorder segments.
Segment 1 - Long (>= 30 residues) disordered segment
Segment is located between positions 19 and 76 in the sequence.
The segment is 58 residues long (7.57 % of the total sequence length).
Segment 2 - Long (>= 30 residues) disordered segment
Segment is located between positions 102 and 235 in the sequence.
The segment is 134 residues long (17.49 % of the total sequence length).
Segment 3 - Long (>= 30 residues) disordered segment
Segment is located between positions 364 and 495 in the sequence.
The segment is 132 residues long (17.23 % of the total sequence length). |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | transcriptional coactivator. |
| References for function | Ohto H, Kamada S, Tago K, Tominaga SI, Ozaki H, Sato S, Kawakami K. Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. Mol Cell Biol. 1999 Oct;19(10):6815-24. doi: 10.1128/mcb.19.10.6815. PMID: 10490620; PMCID: PMC84678. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |
| Function 2 |
| Function description | tyrosine phosphatase |
| References for function | Rebay I, Silver SJ, Tootle TL. New vision from Eyes absent: transcription factors as enzymes. Trends Genet. 2005 Mar;21(3):163-71. doi: 10.1016/j.tig.2005.01.005. PMID: 15734575. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |