| General Information |
| MoonProt ID | 477 |
| First appeared in release | 3.0 |
| Name(s) | Dps
DNA protection during starvation protein. |
| UniProt ID | Q0P891 (DPS_CAMJE) |
| GO terms | GO:0006879 cellular iron ion homeostasis
GO:0055114 oxidation-reduction process
GO:0046872 metal ion binding
GO:0005737 cytoplasm
GO:0016491 oxidoreductase activity
|
| Organisms for which functions have been demonstrated | Campylobacter jejuni |
| Sequence length | 149 amino acids |
| FASTA sequence | >sp|Q0P891|DPS_CAMJE DNA protection during starvation protein OS=Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) OX=192222 GN=dps PE=1 SV=1
MSVTKQLLQMQADAHHLWVKFHNYHWNVKGLQFFSIHEYTEKAYEEMAELFDSCAERVLQLGEKAITCQKVLMENAKSPKVAKDCFTPLEVIELIKQDYEYLLAEFKKLNEAAEKESDTTTAAFAQENIAKYEKSLWMIGATLQGACKM |
| Structure Information |
| PDB ID | 3KWO |
| Quaternary structure | NA |
| SCOP | |
| CATH | 1 matching superfamily.
Superfamily: 1.20.1260.10 CATH superfamily 1.20.1260.10.
4 matching domains. Domain: 3kwoA00 PDB code 3kwo, chain A, domain 00 Superfamily: 1.20.1260.10
Domain: 3kwoB00 PDB code 3kwo, chain B, domain 00 Superfamily: 1.20.1260.10
Domain: 3kwoC00 PDB code 3kwo, chain C, domain 00 Superfamily: 1.20.1260.10
Domain: 3kwoD00 PDB code 3kwo, chain D, domain 00 Superfamily: 1.20.1260.10 |
| TM Helix Prediction | no TM helices
# sp|Q0P891|DPS_CAMJE Number of predicted TMHs: 0
# sp|Q0P891|DPS_CAMJE Exp number of AAs in TMHs: 0.00037
# sp|Q0P891|DPS_CAMJE Exp number, first 60 AAs: 0.00019
# sp|Q0P891|DPS_CAMJE Total prob of N-in: 0.19486
sp|Q0P891|DPS_CAMJE TMHMM2.0 outside 1 149 |
| DisProt Annotation | |
| Predicted Disorder Regions | Use FASTA sequence on MFDp2 webserver.
spQ0P891DPS_CAMJE_DNA_pr is 149 residues long, with 0 residues (0.00 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments. |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | ferritin |
| References for function | Ishikawa T, Mizunoe Y, Kawabata S, Takade A, Harada M, Wai SN, Yoshida S. The iron-binding protein Dps confers hydrogen peroxide stress resistance to Campylobacter jejuni. J Bacteriol. 2003 Feb;185(3):1010-7. doi: 10.1128/jb.185.3.1010-1017.2003. PMID: 12533477; PMCID: PMC142835. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | DNA binding protein. |
| References for function | Huergo LF, Rahman H, Ibrahimovic A, Day CJ, Korolik V. Campylobacter jejuni Dps protein binds DNA in the presence of iron or hydrogen peroxide. J Bacteriol. 2013 May;195(9):1970-8. doi: 10.1128/JB.00059-13. Epub 2013 Feb 22. PMID: 23435977; PMCID: PMC3624597. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |