| General Information |
| MoonProt ID | 480 |
| First appeared in release | 3.0 |
| Name(s) | Sir-2.1, NAD-dependent protein deacetylase sir-2.1 |
| UniProt ID | Q21921 (SIR2_CAEEL) |
| GO terms | GO:0002039 p53 binding
GO:0005637 nuclear inner membrane
GO:0005654 nucleoplasm
GO:0005720 nuclear heterochromatin
GO:0045892 negative regulation of transcription, DNA-templated
GO:0070403 NAD+ binding
GO:0070932 histone H3 deacetylation
"GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005719 nuclear euchromatin
GO:0005737 cytoplasm
GO:0017136 NAD-dependent histone deacetylase activity
GO:0033553 rDNA heterochromatin
GO:0016740 transferase activity |
| Organisms for which functions have been demonstrated | Caenorhabditis elegans |
| Sequence length | 607 amino acids |
| FASTA sequence | >sp|Q21921|SIR2_CAEEL NAD-dependent protein deacetylase sir-2.1 OS=Caenorhabditis elegans OX=6239 GN=sir-2.1 PE=1 SV=1
MSRDSGNDSEVAVTHGEVQEITEENPEIGSMHITQETDISDAPETNTDSSRQRTESTTSVSSESWQNNDEMMSNLRRAQRLLDDGATPLQIIQQIFPDFNASRIATMSENAHFAILSDLLERAPVRQKLTNYNSLADAVELFKTKKHILVLTGAGVSVSCGIPDFRSKDGIYARLRSEFPDLPDPTAMFDIRYFRENPAPFYNFAREIFPGQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTGIKRVVECHGSFSKCTCTRCGQKYDGNEIREEVLAMRVAHCKRCEGVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKVRPVALIPHCVDKNVPQILINRESLPHYNADIELLGNCDDIIRDICFSLGGSFTELITSYDSIMEQQGKTKSQKPSQNKRQLISQEDFLNICMKEKRNDDSSDEPTLKKPRMSVADDSMDSEKNNFQEIQKHKSEDDDDTRNSDDILKKIKHPRLLSITEMLHDNKCVAISAHQTVFPGAECSFDLETLKLVRDVHHETHCESSCGSSCSSNADSEANQLSRAQSLDDFVLSDEDRKNTIHLDLQRADSCDGDFQYELSETIDPETFSHLCEEMRI |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
sp_Q21921_SIR2_CAEEL_NAD is 607 residues long, with 201 residues (33.11 %) predicted as disordered. The protein has 1 short (< 30 residues) disorder segment and 2 long (>= 30 residues) disorder segments. Protein was not aligned to any disorder regions of our templates..
Segment 1 - Long (>= 30 residues) disordered segment
Segment is located between positions 1 and 73 in the sequence.
The segment is 73 residues long (12.03 % of the total sequence length).
Segment 2 - Long (>= 30 residues) disordered segment
Segment is located between positions 392 and 491 in the sequence.
The segment is 100 residues long (16.47 % of the total sequence length).
Segment 3 - Short (< 30 residues) disordered segment
Segment is located between positions 531 and 558 in the sequence.
The segment is 28 residues long (4.61 % of the total sequence length).
|
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | deacetylase |
| References for function | Berdichevsky A, Viswanathan M, Horvitz HR, Guarente L. C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell. 2006 Jun 13;125(6):1165-77. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | transcription regulation |
| References for function | Tissenbaum HA, Guarente L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature. 2001 Mar;410(6825):227-30.
Bamps S, Wirtz J, Savory FR, Lake D, Hope IA. The Caenorhabditis elegans sirtuin gene, sir-2.1, is widely expressed and induced upon caloric restriction. Mechanisms of ageing and development. 2009 Nov 1;130(11-12):762-70. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |