| General Information |
| MoonProt ID | 483 |
| First appeared in release | 3.0 |
| Name(s) | Poly [ADP-ribose] polymerase 1; PARP1 |
| UniProt ID | P11103 (PARP1_MOUSE) |
| GO terms | GO:0005730 nucleolus
GO:1990404 protein ADP-ribosylase activity
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005634 nucleus
GO:0006302 double-strand break repair
GO:0070213 protein auto-ADP-ribosylation
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:1905168 positive regulation of double-strand break repair via homologous recombination P
GO:0030592 DNA ADP-ribosylation
GO:0018424 peptidyl-glutamic acid poly-ADP-ribosylation
GO:0006974 cellular response to DNA damage stimulus
GO:1990966 ATP generation from poly-ADP-D-ribose
GO:0006302 double-strand break repair
GO:0018312 peptidyl-serine ADP-ribosylation
GO:0006471 protein ADP-ribosylation
GO:0008270 zinc ion binding
GO:0003677 DNA binding |
| Organisms for which functions have been demonstrated | Mus musculus |
| Sequence length | 1013 amino acids |
| FASTA sequence | >sp|P11103|PARP1_MOUSE Poly [ADP-ribose] polymerase 1 OS=Mus musculus OX=10090 GN=Parp1 PE=1 SV=3
MAEASERLYRVQYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGQSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVAGKGQDGSGGKAEKTLGDFAAEYAKSNRSMCKGCLEKIEKGQMRLSKKMVDPEKPQLGMIDRWYHPTCFVKKRDELGFRPEYSASQLKGFSLLSAEDKEALKKQLPAIKNEGKRKGDEVDGTDEVAKKKSRKETDKYSKLEKALKAQNELIWNIKDELKKACSTNDLKELLIFNQQQVPSGESAILDRVADGMAFGALLPCKECSGQLVFKSDAYYCTGDVTAWTKCMVKTQNPSRKEWVTPKEFREISYLKKLKVKKQDRIFPPESSAPITVHWPLSVTSAPTAVNSSAPADKPLSNMKILTLGKLSQNKDEAKAVIEKLGGKLTGSANKASLCISIKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQDLLSAHSLSPWGAEVKAEPGEVVAPRGKSAAPSKKSKGCFKEEGVNKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKESRYWIFRSWGRLGTVIGSNKLEQMPSKEEAVEQFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVKPGTKSKLPKPVQELVGMIFDVDSMKKALVEYEIDLQKMPLGKLSRRQIQAAYSILSEVQQPVSQGSSESQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEVIRKYVKNTHATTHNAYDLEVIDIFKIEREGESQRYKPFRQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLIMLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSASITLEGVEVPLGTGIPSGVNDTALLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices
# sp|P11103|PARP1_MOUSE Number of predicted TMHs: 0
# sp|P11103|PARP1_MOUSE Exp number of AAs in TMHs: 0.00921999999999999999
# sp|P11103|PARP1_MOUSE Exp number, first 60 AAs: 0.00023
# sp|P11103|PARP1_MOUSE Total prob of N-in: 0.00002
sp|P11103|PARP1_MOUSE TMHMM2.0 outside 1 1013 |
| DisProt Annotation | |
| Predicted Disorder Regions | Predicted disorder at N terminus (aa 1-7), and middle region (aa 88-102, 140-143, 199-219, 490-515, 523-529, 944-954) |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | poly[ADP-ribose]polymerase 1 |
| References for function | de Murcia G, De Murcia JM. Poly (ADP-ribose) polymerase. A molecular nick sensor. Trends Biochem Sci. 1994;19:172-6. |
| E.C. number | 2.4.2.30 |
| Location of functional site(s) | Active sites: Gln763, Gly863, Tyr889, Tyr869, Lys903, Ser904, Tyr907
Skalitzky DJ, Marakovits JT, Maegley KA, Ekker A, Yu XH, Hostomsky Z, Webber SE, Eastman BW, Almassy R, Li J, Curtin NJ. Tricyclic benzimidazoles as potent poly (ADP-ribose) polymerase-1 inhibitors. Journal of medicinal chemistry. 2003 Jan 16;46(2):210-3. |
| Cellular location of function | nucleus |
| Comments | |
| Function 2 |
| Function description | Transcription factor |
| References for function | Langelier MF, Ruhl DD, Planck JL, Kraus WL, Pascal JM. The Zn3 domain of human poly (ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly (ADP-ribose) synthesis activity and chromatin compaction. Journal of biological chemistry. 2010 Jun 11;285(24):18877-87. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription |