General Information |
MoonProt ID | 495 |
First appeared in release | 3.0 |
Name(s) | Mevalonate kinase
Recommended name:
Mevalonate kinase (EC:2.7.1.36)
Short name:
MK |
UniProt ID | Q4CLD0 (Q4CLD0_TRYCC) |
GO terms | GO:0016740 transferase activity
GO:0016301 kinase activity
GO:0016021 integral component of membrane
GO:0006629 lipid metabolic process
GO:0005524 ATP binding
GO:0016310 phosphorylation
GO:0016020 membrane
GO:0005737 cytoplasm
GO:0016126 sterol biosynthetic process
GO:0000166 nucleotide binding
GO:0008202 steroid metabolic process
GO:0006694 steroid biosynthetic process
GO:0004496 mevalonate kinase activity
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway |
Organisms for which functions have been demonstrated | Trypanosoma cruzi (strain CL Brener) |
Sequence length | 362 amino acids |
FASTA sequence | >tr|Q4CLD0|Q4CLD0_TRYCC Mevalonate kinase (Fragment) OS=Trypanosoma cruzi (strain CL Brener) OX=353153 GN=Tc00.1047053436521.9 PE=3 SV=1
MLLDLFFFFFACHFGVAGGTVCVYSIHFLDYHNIVDMRRAAVERTEKNHIGFGKIILFGEHFVVYGAEALVAGIDEYTSCRLELTKGQPGICVVDGRPAVPGYIVEKAEEQRLAHRLVFRHLNIDTSVDGVRIHLGGPLVPTSGIGASASDVVSLSRALSEMYGLDLTEDEVNLSAFVGEGGYHGTPSGADNTAATFGGLISYRRVNGVSNFCRVLITRPLFLVVCSTGITTSTTKVVGEIRELKENNPTWFNALLERYNACVGEAKAAMEVGNVFRVGELMNENHKLCQELTVSCAELDTIVNFCCENGALGAKMSGTGRGGLVVALAADEAQRDGIADAVRQRCPAAKFVWKYTACPRSA |
Structure Information |
PDB ID | NA |
Quaternary structure | NA |
SCOP | |
CATH | |
TM Helix Prediction | 1(7 - 29) transmembrane protein |
DisProt Annotation | |
Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
trQ4CLD0Q4CLD0_TRYCC_Mev is 362 residues long, with 0 residues (0.00 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments. |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Mevalonate kinase |
References for function | Fu Z, Wang M, Potter D, Miziorko HM, Kim JJ. The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease. J Biol Chem. 2002 May 17;277(20):18134-42. doi: 10.1074/jbc.M200912200. Epub 2002 Feb 27. PMID: 11877411. |
E.C. number | 2.7.1.36 |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | Secreted and modulates cell invasion, binds to receptor |
References for function | Ferreira ÉR, Horjales E, Bonfim-Melo A, Cortez C, da Silva CV, De Groote M, Sobreira TJ, Cruz MC, Lima FM, Cordero EM, Yoshida N, da Silveira JF, Mortara RA, Bahia D. Unique behavior of Trypanosoma cruzi mevalonate kinase: A conserved glycosomal enzyme involved in host cell invasion and signaling. Sci Rep. 2016 Apr 26;6:24610. doi: 10.1038/srep24610. PMID: 27113535; PMCID: PMC4845012. |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | extracellular |
Comments | |