Protein Information

General Information
MoonProt ID495
First appeared in release3.0
Name(s)Mevalonate kinase Recommended name: Mevalonate kinase (EC:2.7.1.36) Short name: MK
UniProt IDQ4CLD0 (Q4CLD0_TRYCC)
GO termsGO:0016740 transferase activity GO:0016301 kinase activity GO:0016021 integral component of membrane GO:0006629 lipid metabolic process GO:0005524 ATP binding GO:0016310 phosphorylation GO:0016020 membrane GO:0005737 cytoplasm GO:0016126 sterol biosynthetic process GO:0000166 nucleotide binding GO:0008202 steroid metabolic process GO:0006694 steroid biosynthetic process GO:0004496 mevalonate kinase activity GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
Organisms for which functions have been demonstratedTrypanosoma cruzi (strain CL Brener)
Sequence length362 amino acids
FASTA sequence>tr|Q4CLD0|Q4CLD0_TRYCC Mevalonate kinase (Fragment) OS=Trypanosoma cruzi (strain CL Brener) OX=353153 GN=Tc00.1047053436521.9 PE=3 SV=1 MLLDLFFFFFACHFGVAGGTVCVYSIHFLDYHNIVDMRRAAVERTEKNHIGFGKIILFGEHFVVYGAEALVAGIDEYTSCRLELTKGQPGICVVDGRPAVPGYIVEKAEEQRLAHRLVFRHLNIDTSVDGVRIHLGGPLVPTSGIGASASDVVSLSRALSEMYGLDLTEDEVNLSAFVGEGGYHGTPSGADNTAATFGGLISYRRVNGVSNFCRVLITRPLFLVVCSTGITTSTTKVVGEIRELKENNPTWFNALLERYNACVGEAKAAMEVGNVFRVGELMNENHKLCQELTVSCAELDTIVNFCCENGALGAKMSGTGRGGLVVALAADEAQRDGIADAVRQRCPAAKFVWKYTACPRSA
Structure Information
PDB IDNA
Quaternary structureNA
SCOP
CATH
TM Helix Prediction1(7 - 29) transmembrane protein
DisProt Annotation
Predicted Disorder RegionsUse FASTA sequence on the MFDp2 webserver. trQ4CLD0Q4CLD0_TRYCC_Mev is 362 residues long, with 0 residues (0.00 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments.
Connections to Disease
OMIM ID
Function 1
Function descriptionMevalonate kinase
References for functionFu Z, Wang M, Potter D, Miziorko HM, Kim JJ. The structure of a binary complex between a mammalian mevalonate kinase and ATP: insights into the reaction mechanism and human inherited disease. J Biol Chem. 2002 May 17;277(20):18134-42. doi: 10.1074/jbc.M200912200. Epub 2002 Feb 27. PMID: 11877411.
E.C. number2.7.1.36
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionSecreted and modulates cell invasion, binds to receptor
References for functionFerreira ÉR, Horjales E, Bonfim-Melo A, Cortez C, da Silva CV, De Groote M, Sobreira TJ, Cruz MC, Lima FM, Cordero EM, Yoshida N, da Silveira JF, Mortara RA, Bahia D. Unique behavior of Trypanosoma cruzi mevalonate kinase: A conserved glycosomal enzyme involved in host cell invasion and signaling. Sci Rep. 2016 Apr 26;6:24610. doi: 10.1038/srep24610. PMID: 27113535; PMCID: PMC4845012.
E.C. number
Location of functional site(s)
Cellular location of functionextracellular
Comments