Protein Information

General Information
MoonProt ID503
First appeared in release3.0
Name(s)LD47455p Gene Sf3a2
UniProt IDQ9VU15 (Q9VU15_DROME)
GO termsGO:0000245 spliceosomal complex assembly GO:0000398 mRNA splicing, via spliceosome GO:0003676 nucleic acid binding GO:0003723 RNA binding GO:0005634 nucleus GO:0005681 spliceosomal complex GO:0005686 U2 snRNP GO:0006397 mRNA processing GO:0008270 zinc ion binding GO:0008380 RNA splicing GO:0010628 positive regulation of gene expression GO:0071004 U2-type prespliceosome GO:0071011 precatalytic spliceosome GO:0071013 catalytic step 2 spliceosome
Organisms for which functions have been demonstratedDrosophila melanogaster (fruit fly, an insect)
Sequence length264 amino acids
FASTA sequence>tr|Q9VU15|Q9VU15_DROME LD47455p OS=Drosophila melanogaster OX=7227 GN=Sf3a2 PE=1 SV=1 MDFQNRAGGKTGSGGVASWSETNRDRKERLRQLALETIDLNKDPYFMKNHLGSYECKLCL TLHNNEGSYLAHTQGKKHQDNLARRAAKEAKEAPSSLLAPEKPRVEPKKFVKIGRPGYRV TKQRELSNGQQSLLFQVDYPEITESIVPRHRFMSAYEQKIEPPDRKWQYLLFAAEPYETI GFKVPSREVEKSEGKFWTHWNRDTKQFFLQFAFKFEPKILPPPPPNLHRALGPPGGFPMP GPPRPAMHPMFNGVHPPPPMLSNN
Structure Information
PDB IDclosest is human at 82%amino acid sequence identity
Quaternary structureNA
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder RegionsNA
Connections to Disease
OMIM ID
Function 1
Function descriptioncomponent of spliceosome
References for function18981222
E.C. numberNA
Location of functional site(s)NA
Cellular location of functioncytoplasm, spliceosome
CommentsNA
Function 2
Function descriptionbinds Ndc80, Mitch, and Nuf2 (Ndc80 complex) without it see Reduced accumulation of Ndc80 at kinetochores and severe defects in chromosome alignment
References for function30475206
E.C. numberNA
Location of functional site(s)NA
Cellular location of functionmitotic spindle
CommentsNA