General Information |
MoonProt ID | 503 |
First appeared in release | 3.0 |
Name(s) | LD47455p
Gene
Sf3a2 |
UniProt ID | Q9VU15 (Q9VU15_DROME) |
GO terms | GO:0000245 spliceosomal complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005686 U2 snRNP
GO:0006397 mRNA processing
GO:0008270 zinc ion binding
GO:0008380 RNA splicing
GO:0010628 positive regulation of gene expression
GO:0071004 U2-type prespliceosome
GO:0071011 precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome
|
Organisms for which functions have been demonstrated | Drosophila melanogaster (fruit fly, an insect) |
Sequence length | 264 amino acids |
FASTA sequence | >tr|Q9VU15|Q9VU15_DROME LD47455p OS=Drosophila melanogaster OX=7227 GN=Sf3a2 PE=1 SV=1
MDFQNRAGGKTGSGGVASWSETNRDRKERLRQLALETIDLNKDPYFMKNHLGSYECKLCL
TLHNNEGSYLAHTQGKKHQDNLARRAAKEAKEAPSSLLAPEKPRVEPKKFVKIGRPGYRV
TKQRELSNGQQSLLFQVDYPEITESIVPRHRFMSAYEQKIEPPDRKWQYLLFAAEPYETI
GFKVPSREVEKSEGKFWTHWNRDTKQFFLQFAFKFEPKILPPPPPNLHRALGPPGGFPMP
GPPRPAMHPMFNGVHPPPPMLSNN |
Structure Information |
PDB ID | closest is human at 82%amino acid sequence identity |
Quaternary structure | NA |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | NA |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | component of spliceosome |
References for function | 18981222 |
E.C. number | NA |
Location of functional site(s) | NA |
Cellular location of function | cytoplasm, spliceosome |
Comments | NA |
Function 2 |
Function description | binds Ndc80, Mitch, and Nuf2 (Ndc80 complex) without it see Reduced accumulation of Ndc80 at kinetochores and severe defects in chromosome alignment |
References for function | 30475206 |
E.C. number | NA |
Location of functional site(s) | NA |
Cellular location of function | mitotic spindle |
Comments | NA |