Protein Information

General Information
MoonProt ID504
First appeared in release3.0
Name(s)Pre-mRNA-processing factor 31 Gene Prp31
UniProt IDQ9VUM1 (Q9VUM1_DROME)
GO termsGO TERM GO NAME GO:0000244 spliceosomal tri-snRNP complex assembly GO:0000398 mRNA splicing, via spliceosome GO:0000398 mRNA splicing, via spliceosome GO:0000398 mRNA splicing, via spliceosome GO:0000398 mRNA splicing, via spliceosome GO:0003723 RNA binding GO:0003723 RNA binding GO:0005634 nucleus GO:0005681 spliceosomal complex GO:0005681 spliceosomal complex GO:0005687 U4 snRNP GO:0006397 mRNA processing GO:0008380 RNA splicing GO:0043021 ribonucleoprotein complex binding GO:0046540 U4/U6 x U5 tri-snRNP complex GO:0071011 precatalytic spliceosome GO:0071011 precatalytic spliceosome GO:0097526 spliceosomal tri-snRNP complex
Organisms for which functions have been demonstratedDrosophila melanogaster (fruit fly, an insect)
Sequence length501 amino acids
FASTA sequence>tr|Q9VUM1|Q9VUM1_DROME Pre-mRNA-processing factor 31 OS=Drosophila melanogaster OX=7227 GN=Prp31 PE=1 SV=1 MSLADELLADLEEDNDNELEEEDSEMASAEDESLLAEKLAKPAPNLMDVDVTVQSVRELC KLRDSERLKNTLQQIEHYASRQRTAAEMLGSVESDPEYCLIVDANAIAVDIDNEISIVHK FTKEKYQKRFPELDSLIVGEIEYLLAVKELGNDLDQVKNNEKLQAILTQATIMIVSVTAS TTQGTMLTPAEKAKIDEACEMAIELNNFKSKIYEYVESRMTFIAPNLSMIVGASTAAKLL GIAGGLSKLSKMPACNVQVLGAQKKTLSGFSQTQMLPHTGYVYYSQIVQDTAPDLRRKAA RLVAAKSVLAARVDACHESVHGEIGLRFKEDVEKKLDKLQEPPPVKFIKPLPKPIEGSKK KRGGKRVRKMKERYALTEFRKQANRMNFGDIEEDAYQGDLGYSRGTIGKTGTGRIRLPQV DEKTKVRISKTLHKNLQKQQVYGGNTTVKRQISGTASSVAFTPLQGLEIVNPQAAERSQT EANAKYFSNTSGFMSVGQRTT
Structure Information
PDB IDclosest is human at 62% amino acid sequence identity
Quaternary structureNA
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder RegionsNA
Connections to Disease
OMIM ID
Function 1
Function descriptioncomponent of spliceosome
References for function10908584
E.C. numberNA
Location of functional site(s)NA
Cellular location of functioncytoplasm, spliceosome
CommentsNA
Function 2
Function descriptionbinds Ndc80, Mitch, and Nuf2 (Ndc80 complex) without it see Reduced accumulation of Ndc80 at kinetochores and severe defects in chromosome alignment
References for function30475206
E.C. numberNA
Location of functional site(s)NA
Cellular location of functionmitotic spindle
CommentsNA