Protein Information

General Information
MoonProt ID505
First appeared in release3.0
Name(s)Citrate synthase CitA
UniProt IDA0A0H3C985 (A0A0H3C985_CAUVN)
GO termsGO:0006099 tricarboxylic acid cycle GO:0016740 transferase activity GO:0016746 transferase activity, transferring acyl groups
Organisms for which functions have been demonstratedCaulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
Sequence length426 amino acids
FASTA sequence>tr|A0A0H3C985|A0A0H3C985_CAUVN Citrate synthase OS=Caulobacter vibrioides (strain NA1000 / CB15N) OX=565050 GN=CCNA_01983 PE=3 SV=1 MTDKATLTIGDKSYELPILKGSTGPDVIDVRKIYGESDHFTFDPGFTSTASCESKITYID GDAGILLHRGYPIDQLAEKSSFLEVCYLLLNGELPKADEFAKFEHNITYHTMLHAQFDRF FEGFRRDAHPMAVMTGAVGALSAFYSDSINVDDAREREISAHRLIAKMPTIAARAYKYTVGQPFVSPRNDLSYSENFLRMCFAVPAEDWKPNPVLTRAMDRIFILHADHEQNASTSTVRLAGSSGAHPFACIAAGIACLWGPSHGGANQEALEMLETIGSVDNIKDYVQGVKDRKYKLMGFGHRVYKNFDPRAKVMQKTAHEVLAELGHNNDPLLQVAQELEKVALNDPYFVDRKLYPNIDFYSGITLRAMGFPTNMFTVLFALARTVGWISQWKEMFEDPTRKIGRPRQLYTGATHRDYVTLDKR
Structure Information
PDB IDNA
Quaternary structureNA
SCOP
CATH
TM Helix Predictionno TM helices # tr|A0A0H3C985|A0A0H3C985_CAUVN Number of predicted TMHs: 0 # tr|A0A0H3C985|A0A0H3C985_CAUVN Exp number of AAs in TMHs: 7.10364 # tr|A0A0H3C985|A0A0H3C985_CAUVN Exp number, first 60 AAs: 0 # tr|A0A0H3C985|A0A0H3C985_CAUVN Total prob of N-in: 0.03445 tr|A0A0H3C985|A0A0H3C985_CAUVN TMHMM2.0 outside 1 426
DisProt Annotation
Predicted Disorder RegionsUse FASTA sequence on the MFDp2 webserver. trA0A0H3C985A0A0H3C985_C is 426 residues long, with 5 residues (1.17 %) predicted as disordered. The protein has 1 short (< 30 residues) disorder segment and 0 long (>= 30 residues) disorder segments. Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 422 and 426 in the sequence. The segment is 5 residues long (1.17 % of the total sequence length).
Connections to Disease
OMIM ID
Function 1
Function descriptioncitrate synthase
References for functionBergé M, Pezzatti J, González-Ruiz V, Degeorges L, Mottet-Osman G, Rudaz S, Viollier PH. Bacterial cell cycle control by citrate synthase independent of enzymatic activity. Elife. 2020 Mar 9;9:e52272. doi: 10.7554/eLife.52272. PMID: 32149608; PMCID: PMC7083601.
E.C. number2.3.3.16
Location of functional site(s)
Cellular location of function
Comments
Function 2
Function descriptioncell cycle control (enzyme function not needed)
References for functionBergé M, Pezzatti J, González-Ruiz V, Degeorges L, Mottet-Osman G, Rudaz S, Viollier PH. Bacterial cell cycle control by citrate synthase independent of enzymatic activity. Elife. 2020 Mar 9;9:e52272. doi: 10.7554/eLife.52272. PMID: 32149608; PMCID: PMC7083601.
E.C. number
Location of functional site(s)
Cellular location of function
Comments